4BWL
Structure of the Y137A mutant of E. coli N-acetylneuraminic acid lyase in complex with pyruvate, N-acetyl-D-mannosamine and N- acetylneuraminic acid
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0005975 | biological_process | carbohydrate metabolic process |
A | 0008747 | molecular_function | N-acetylneuraminate lyase activity |
A | 0016829 | molecular_function | lyase activity |
A | 0019262 | biological_process | N-acetylneuraminate catabolic process |
A | 0042802 | molecular_function | identical protein binding |
A | 0044010 | biological_process | single-species biofilm formation |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0005975 | biological_process | carbohydrate metabolic process |
B | 0008747 | molecular_function | N-acetylneuraminate lyase activity |
B | 0016829 | molecular_function | lyase activity |
B | 0019262 | biological_process | N-acetylneuraminate catabolic process |
B | 0042802 | molecular_function | identical protein binding |
B | 0044010 | biological_process | single-species biofilm formation |
C | 0005737 | cellular_component | cytoplasm |
C | 0005829 | cellular_component | cytosol |
C | 0005975 | biological_process | carbohydrate metabolic process |
C | 0008747 | molecular_function | N-acetylneuraminate lyase activity |
C | 0016829 | molecular_function | lyase activity |
C | 0019262 | biological_process | N-acetylneuraminate catabolic process |
C | 0042802 | molecular_function | identical protein binding |
C | 0044010 | biological_process | single-species biofilm formation |
D | 0005737 | cellular_component | cytoplasm |
D | 0005829 | cellular_component | cytosol |
D | 0005975 | biological_process | carbohydrate metabolic process |
D | 0008747 | molecular_function | N-acetylneuraminate lyase activity |
D | 0016829 | molecular_function | lyase activity |
D | 0019262 | biological_process | N-acetylneuraminate catabolic process |
D | 0042802 | molecular_function | identical protein binding |
D | 0044010 | biological_process | single-species biofilm formation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE SI3 A 1165 |
Chain | Residue |
A | SER47 |
A | GLY207 |
A | SER208 |
A | PHE252 |
A | HOH2003 |
A | THR48 |
A | ILE139 |
A | LYS165 |
A | THR167 |
A | GLY189 |
A | TYR190 |
A | ASP191 |
A | GLU192 |
site_id | AC2 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE SI3 B 1165 |
Chain | Residue |
B | TYR43 |
B | GLY46 |
B | SER47 |
B | THR48 |
B | LYS165 |
B | THR167 |
B | GLY189 |
B | ASP191 |
B | GLU192 |
B | GLY207 |
B | SER208 |
B | PHE252 |
B | HOH2004 |
B | HOH2021 |
site_id | AC3 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE SI3 D 1165 |
Chain | Residue |
D | TYR43 |
D | SER47 |
D | THR48 |
D | LYS165 |
D | THR167 |
D | GLY189 |
D | TYR190 |
D | ASP191 |
D | GLU192 |
D | ILE206 |
D | GLY207 |
D | SER208 |
D | PHE252 |
D | HOH2009 |
site_id | AC4 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE MN9 C 1297 |
Chain | Residue |
C | ILE139 |
C | LEU142 |
C | KPI165 |
C | THR167 |
C | GLY189 |
C | ASP191 |
C | GLU192 |
C | GLY207 |
C | SER208 |
C | PHE252 |
site_id | AC5 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE 1PE B 1297 |
Chain | Residue |
B | ASP170 |
B | HOH2014 |
Functional Information from PROSITE/UniProt
site_id | PS00665 |
Number of Residues | 18 |
Details | DHDPS_1 Dihydrodipicolinate synthase signature 1. GLYvgGSTGEAfvqslsE |
Chain | Residue | Details |
A | GLY41-GLU58 | |
C | GLY41-GLU58 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Proton donor => ECO:0000305|PubMed:24521460 |
Chain | Residue | Details |
C | ALA137 | |
B | ALA137 | |
D | ALA137 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | ACT_SITE: Schiff-base intermediate with substrate => ECO:0000269|PubMed:12711733, ECO:0000269|PubMed:19923724, ECO:0000269|PubMed:24521460, ECO:0000269|PubMed:9047371, ECO:0000305|PubMed:8081752 |
Chain | Residue | Details |
C | KPI165 | |
B | LYS165 | |
D | LYS165 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:9047371, ECO:0000305|PubMed:12711733, ECO:0007744|PDB:1FDY, ECO:0007744|PDB:1FDZ, ECO:0007744|PDB:1HL2 |
Chain | Residue | Details |
B | THR48 | |
D | SER47 | |
D | THR48 | |
C | SER47 | |
C | THR48 | |
B | SER47 |
site_id | SWS_FT_FI4 |
Number of Residues | 5 |
Details | BINDING: BINDING => ECO:0000269|PubMed:24521460, ECO:0007744|PDB:4BWL |
Chain | Residue | Details |
C | THR167 | |
C | GLY189 | |
C | ASP191 | |
C | GLU192 | |
C | SER208 | |
B | THR167 | |
B | GLY189 | |
B | ASP191 | |
B | GLU192 | |
B | SER208 | |
D | THR167 | |
D | GLY189 | |
D | ASP191 | |
D | GLU192 | |
D | SER208 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | SITE: Required to correctly position the proton donor => ECO:0000305|PubMed:24521460 |
Chain | Residue | Details |
C | SER47 | |
C | TYR110 | |
B | SER47 | |
B | TYR110 | |
D | SER47 | |
D | TYR110 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 2 |
Details | M-CSA 553 |
Chain | Residue | Details |
C | ALA137 | proton acceptor, proton donor, proton relay |
C | KPI165 | covalently attached, electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor |
site_id | MCSA2 |
Number of Residues | 2 |
Details | M-CSA 553 |
Chain | Residue | Details |
B | ALA137 | proton acceptor, proton donor, proton relay |
B | LYS165 | covalently attached, electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor |
site_id | MCSA3 |
Number of Residues | 2 |
Details | M-CSA 553 |
Chain | Residue | Details |
D | ALA137 | proton acceptor, proton donor, proton relay |
D | LYS165 | covalently attached, electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor |