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4BW5

Crystal structure of human two pore domain potassium ion channel TREK2 (K2P10.1)

Functional Information from GO Data
ChainGOidnamespacecontents
A0005267molecular_functionpotassium channel activity
A0016020cellular_componentmembrane
A0071805biological_processpotassium ion transmembrane transport
B0005267molecular_functionpotassium channel activity
B0016020cellular_componentmembrane
B0071805biological_processpotassium ion transmembrane transport
C0005267molecular_functionpotassium channel activity
C0016020cellular_componentmembrane
C0071805biological_processpotassium ion transmembrane transport
D0005267molecular_functionpotassium channel activity
D0016020cellular_componentmembrane
D0071805biological_processpotassium ion transmembrane transport
Functional Information from PDB Data
site_idAC1
Number of Residues9
DetailsBINDING SITE FOR RESIDUE K A 600
ChainResidue
AGLY174
ATYR175
AGLY283
APHE284
AK601
BGLY174
BTYR175
BGLY283
BPHE284

site_idAC2
Number of Residues10
DetailsBINDING SITE FOR RESIDUE K A 601
ChainResidue
AILE173
AGLY174
AVAL282
AGLY283
AK600
AK602
BILE173
BGLY174
BVAL282
BGLY283

site_idAC3
Number of Residues10
DetailsBINDING SITE FOR RESIDUE K A 602
ChainResidue
ATHR172
AILE173
ATHR281
AVAL282
AK601
AK603
BTHR172
BILE173
BTHR281
BVAL282

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE K A 603
ChainResidue
ATHR172
ATHR281
AK602
BTHR172
BTHR281

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CD A 701
ChainResidue
BGLU113
BGLU116
DARG119
DASP120

site_idAC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CD A 702
ChainResidue
BASP120
DGLU113
DGLU116

site_idAC7
Number of Residues1
DetailsBINDING SITE FOR RESIDUE PC1 B 800
ChainResidue
BLEU304

site_idAC8
Number of Residues9
DetailsBINDING SITE FOR RESIDUE K C 600
ChainResidue
CGLY174
CTYR175
CGLY283
CPHE284
CK601
DGLY174
DTYR175
DGLY283
DPHE284

site_idAC9
Number of Residues10
DetailsBINDING SITE FOR RESIDUE K C 601
ChainResidue
CILE173
CGLY174
CVAL282
CGLY283
CK600
CK602
DILE173
DGLY174
DVAL282
DGLY283

site_idBC1
Number of Residues10
DetailsBINDING SITE FOR RESIDUE K C 602
ChainResidue
CTHR172
CILE173
CTHR281
CVAL282
CK601
CK603
DTHR172
DILE173
DTHR281
DVAL282

site_idBC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE K C 603
ChainResidue
CTHR172
CTHR281
CK602
DTHR172
DTHR281

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues320
DetailsTransmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues104
DetailsIntramembrane: {"description":"Pore-forming; Name=Pore-forming 1","evidences":[{"source":"PDB","id":"4BW5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues62
DetailsIntramembrane: {"description":"Pore-forming; Name=Pore-forming 2","evidences":[{"source":"PDB","id":"4BW5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues20
DetailsRegion: {"description":"Selectivity filter 1","evidences":[{"source":"PubMed","id":"25766236","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues20
DetailsRegion: {"description":"Selectivity filter 2","evidences":[{"source":"PubMed","id":"25766236","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues32
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"25766236","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4XDK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues4
DetailsSite: {"description":"pH sensor","evidences":[{"source":"UniProtKB","id":"Q8BUW1","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues60
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

239149

PDB entries from 2025-07-23

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