4BTF
Structure of MLKL
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0007166 | biological_process | cell surface receptor signaling pathway |
| A | 0012501 | biological_process | programmed cell death |
| A | 0019901 | molecular_function | protein kinase binding |
| A | 0030054 | cellular_component | cell junction |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0044877 | molecular_function | protein-containing complex binding |
| A | 0051607 | biological_process | defense response to virus |
| A | 0070207 | biological_process | protein homotrimerization |
| A | 0070266 | biological_process | necroptotic process |
| A | 0097527 | biological_process | necroptotic signaling pathway |
| A | 0097528 | biological_process | execution phase of necroptosis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE FMT A 1456 |
| Chain | Residue |
| A | VAL364 |
| A | ARG368 |
| A | TYR376 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 1457 |
| Chain | Residue |
| A | HIS190 |
| A | TYR211 |
| A | HIS212 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by RIPK3","evidences":[{"source":"PubMed","id":"24012422","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24095729","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine; by RIPK3","evidences":[{"source":"PubMed","id":"24012422","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24095729","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
