4BDV

CRYSTAL STRUCTURE OF A TRUNCATED B-DOMAIN HUMAN FACTOR VIII

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005507	molecular_function	copper ion binding
B	0005507	molecular_function	copper ion binding
B	0016491	molecular_function	oxidoreductase activity

Functional Information from PROSITE/UniProt

site_id	PS00079
Number of Residues	21
Details	MULTICOPPER_OXIDASE1 Multicopper oxidases signature 1. GqFlLfChISshQhDGMeayV

Chain	Residue	Details
A	GLY304-VAL324
A	GLY686-LEU706
B	GLY1994-PHE2014

---

site_id	PS01285
Number of Residues	28
Details	FA58C_1 Coagulation factors 5/8 type C domain (FA58C) signature 1. AWstkepfs........WIkVDllapmiIhgIkTQG

Chain	Residue	Details
B	ALA2061-GLY2088
B	ALA2218-GLY2247

---

site_id	PS01286
Number of Residues	17
Details	FA58C_2 Coagulation factors 5/8 type C domain (FA58C) signature 2. Pthysirst..LRmELmGC

Chain	Residue	Details
B	PRO2153-CYS2169
B	PRO2310-CYS2326

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Cleavage (activation)

Chain	Residue	Details
B	ARG1648
A	ARG740

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Cleavage; by thrombin

Chain	Residue	Details
B	ARG1689

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Sulfotyrosine => ECO:0000269|PubMed:10368977, ECO:0000269|PubMed:1554716

Chain	Residue	Details
B	TYR1664
A	TYR719
A	TYR723

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Sulfotyrosine => ECO:0000269|PubMed:10368977, ECO:0000269|PubMed:1554716, ECO:0000269|PubMed:1898735

Chain	Residue	Details
B	TYR1680
A	ASN239

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
B	ASN1810
B	ASN2118

---