4B94
Crystal structure of human Mps1 TPR domain
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004712 | molecular_function | protein serine/threonine/tyrosine kinase activity |
| A | 0007093 | biological_process | mitotic cell cycle checkpoint signaling |
| A | 0051304 | biological_process | chromosome separation |
| B | 0004712 | molecular_function | protein serine/threonine/tyrosine kinase activity |
| B | 0007093 | biological_process | mitotic cell cycle checkpoint signaling |
| B | 0051304 | biological_process | chromosome separation |
| C | 0004712 | molecular_function | protein serine/threonine/tyrosine kinase activity |
| C | 0007093 | biological_process | mitotic cell cycle checkpoint signaling |
| C | 0051304 | biological_process | chromosome separation |
| D | 0004712 | molecular_function | protein serine/threonine/tyrosine kinase activity |
| D | 0007093 | biological_process | mitotic cell cycle checkpoint signaling |
| D | 0051304 | biological_process | chromosome separation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PG4 A 1200 |
| Chain | Residue |
| A | PRO-1 |
| A | ASP64 |
| A | TRP65 |
| A | LEU68 |
| C | GLU96 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 1201 |
| Chain | Residue |
| A | LYS140 |
| A | LYS141 |
| A | ARG172 |
| A | HOH2064 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 1202 |
| Chain | Residue |
| A | GLU124 |
| A | ASP127 |
| A | TYR131 |
| A | HOH2048 |
| C | ARG136 |
| C | HIS146 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 1196 |
| Chain | Residue |
| B | GLU96 |
| B | ALA97 |
| B | PRO99 |
| B | HOH2017 |
| B | HOH2058 |
| D | GLN93 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PGE B 1197 |
| Chain | Residue |
| B | PRO-1 |
| B | ASP64 |
| B | ARG90 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL B 1198 |
| Chain | Residue |
| B | ASP101 |
| B | ALA137 |
| B | ASN138 |
| B | HOH2018 |
| B | HOH2048 |
| B | HOH2059 |
| D | ASN85 |
| D | LYS120 |
| D | GLN123 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE MLI B 1199 |
| Chain | Residue |
| B | ARG136 |
| B | ALA137 |
| B | LYS140 |
| B | HIS146 |
| B | LYS168 |
| B | ARG172 |
| B | HOH2047 |
| D | GLU124 |
| D | ASP127 |
| D | TYR131 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 1200 |
| Chain | Residue |
| B | LYS140 |
| B | LYS141 |
| B | ARG172 |
| B | ALA174 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 1201 |
| Chain | Residue |
| B | GLY0 |
| B | GLU63 |
| B | TYR103 |
| B | ASN106 |
| B | HOH2004 |
| D | LYS141 |
| site_id | BC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE MLI B 1202 |
| Chain | Residue |
| B | LYS102 |
| B | TYR103 |
| B | GLY104 |
| B | GLN105 |
| B | ASN106 |
| B | HOH2060 |
| D | LYS141 |
| D | HOH2022 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PGE C 1196 |
| Chain | Residue |
| C | PRO-1 |
| C | ASP64 |
| C | LEU68 |
| C | ARG90 |
| site_id | BC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PEG C 1197 |
| Chain | Residue |
| A | TYR103 |
| A | GLN105 |
| A | ASN106 |
| C | GLN105 |
| C | LYS141 |
| C | GOL1198 |
| C | HOH2044 |
| C | HOH2045 |
| site_id | BC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL C 1198 |
| Chain | Residue |
| A | GLY0 |
| A | PRO62 |
| A | GLU63 |
| A | TYR103 |
| A | ASN106 |
| C | LYS141 |
| C | PEG1197 |
| C | HOH2046 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PG4 D 1200 |
| Chain | Residue |
| B | GLU96 |
| D | PRO-1 |
| D | ASP64 |
| D | TRP65 |
| D | LEU68 |
| D | HOH2048 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL D 1201 |
| Chain | Residue |
| D | LYS140 |
| D | HIS146 |
| D | ARG172 |
| D | HOH2044 |
| site_id | BC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL D 1202 |
| Chain | Residue |
| B | GLN105 |
| B | LYS141 |
| D | LYS102 |
| D | TYR103 |
| D | ASN106 |
| D | HOH2018 |
| D | HOH2023 |
| site_id | BC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL D 1203 |
| Chain | Residue |
| D | ARG136 |
| D | ALA137 |
| D | LYS140 |
| D | ARG172 |
| D | HOH2049 |
| D | GLN133 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
