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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4B4O

Crystal Structure of human epimerase family protein SDR39U1 (isoform2) with NADPH

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0005739	cellular_component	mitochondrion
A	0016491	molecular_function	oxidoreductase activity
B	0005634	cellular_component	nucleus
B	0005739	cellular_component	mitochondrion
B	0016491	molecular_function	oxidoreductase activity
C	0005634	cellular_component	nucleus
C	0005739	cellular_component	mitochondrion
C	0016491	molecular_function	oxidoreductase activity
D	0005634	cellular_component	nucleus
D	0005739	cellular_component	mitochondrion
D	0016491	molecular_function	oxidoreductase activity
E	0005634	cellular_component	nucleus
E	0005739	cellular_component	mitochondrion
E	0016491	molecular_function	oxidoreductase activity
F	0005634	cellular_component	nucleus
F	0005739	cellular_component	mitochondrion
F	0016491	molecular_function	oxidoreductase activity
G	0005634	cellular_component	nucleus
G	0005739	cellular_component	mitochondrion
G	0016491	molecular_function	oxidoreductase activity
H	0005634	cellular_component	nucleus
H	0005739	cellular_component	mitochondrion
H	0016491	molecular_function	oxidoreductase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	29
Details	BINDING SITE FOR RESIDUE NDP A 999

Chain	Residue
A	GLY7
A	GLY60
A	GLU61
A	ASN62
A	GLU77
A	SER81
A	ARG82
A	VAL106
A	THR107
A	TRP139
A	SER157
A	THR9
A	GLY158
A	VAL160
A	PE41296
A	HOH2001
A	HOH2002
A	HOH2009
A	HOH2013
A	HOH2015
A	HOH2034
A	HOH2089
A	GLY10
A	PHE11
A	ILE12
A	SER31
A	ARG32
A	LEU58
A	ALA59

site_id	AC2
Number of Residues	24
Details	BINDING SITE FOR RESIDUE NDP B 999

Chain	Residue
B	GLY7
B	THR9
B	GLY10
B	PHE11
B	ILE12
B	SER31
B	ARG32
B	LEU58
B	ALA59
B	GLY60
B	GLU61
B	ASN62
B	SER81
B	ARG82
B	VAL106
B	THR107
B	TRP139
B	SER157
B	GLY158
B	VAL160
B	PE41296
B	HOH2001
B	HOH2002
B	HOH2008

site_id	AC3
Number of Residues	28
Details	BINDING SITE FOR RESIDUE NDP C 999

Chain	Residue
C	GLY7
C	THR9
C	GLY10
C	PHE11
C	ILE12
C	SER31
C	ARG32
C	LEU58
C	ALA59
C	GLY60
C	GLU61
C	ASN62
C	SER81
C	ARG82
C	VAL106
C	THR107
C	TRP139
C	SER157
C	GLY158
C	VAL159
C	VAL160
C	PE41296
C	HOH2001
C	HOH2002
C	HOH2009
C	HOH2015
C	HOH2016
C	HOH2074

site_id	AC4
Number of Residues	26
Details	BINDING SITE FOR RESIDUE NDP D 999

Chain	Residue
D	GLY158
D	VAL160
D	PE41296
D	HOH2001
D	HOH2002
D	HOH2008
D	HOH2017
D	HOH2066
D	GLY7
D	THR9
D	GLY10
D	PHE11
D	ILE12
D	SER31
D	ARG32
D	LEU58
D	ALA59
D	GLY60
D	GLU61
D	ASN62
D	GLU77
D	SER81
D	ARG82
D	THR107
D	TRP139
D	SER157

site_id	AC5
Number of Residues	26
Details	BINDING SITE FOR RESIDUE NDP E 999

Chain	Residue
E	GLY7
E	THR9
E	GLY10
E	PHE11
E	ILE12
E	SER31
E	ARG32
E	LEU58
E	ALA59
E	GLY60
E	GLU61
E	ASN62
E	SER81
E	ARG82
E	VAL106
E	THR107
E	TRP139
E	SER157
E	GLY158
E	VAL160
E	PE41296
E	HOH2001
E	HOH2002
E	HOH2005
E	HOH2008
E	HOH2046

site_id	AC6
Number of Residues	28
Details	BINDING SITE FOR RESIDUE NDP F 999

Chain	Residue
F	GLY7
F	THR9
F	GLY10
F	PHE11
F	ILE12
F	SER31
F	ARG32
F	LEU58
F	ALA59
F	GLY60
F	GLU61
F	ASN62
F	GLU77
F	SER81
F	ARG82
F	VAL106
F	THR107
F	TRP139
F	SER157
F	GLY158
F	VAL160
F	PE41296
F	HOH2001
F	HOH2002
F	HOH2004
F	HOH2028
F	HOH2051
F	HOH2052

site_id	AC7
Number of Residues	26
Details	BINDING SITE FOR RESIDUE NDP G 999

Chain	Residue
G	GLY7
G	THR9
G	GLY10
G	PHE11
G	ILE12
G	SER31
G	ARG32
G	LEU58
G	ALA59
G	GLY60
G	GLU61
G	ASN62
G	SER81
G	ARG82
G	THR107
G	TRP139
G	SER157
G	GLY158
G	VAL160
G	PE41295
G	HOH2001
G	HOH2002
G	HOH2008
G	HOH2014
G	HOH2034
G	HOH2060

site_id	AC8
Number of Residues	27
Details	BINDING SITE FOR RESIDUE NDP H 999

Chain	Residue
H	GLY7
H	THR9
H	GLY10
H	PHE11
H	ILE12
H	SER31
H	ARG32
H	LEU58
H	ALA59
H	GLY60
H	GLU61
H	ASN62
H	SER81
H	ARG82
H	VAL106
H	THR107
H	TRP139
H	SER157
H	GLY158
H	VAL160
H	PE41296
H	HOH2001
H	HOH2002
H	HOH2003
H	HOH2005
H	HOH2007
H	HOH2017

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PE4 D 1296

Chain	Residue
D	ILE63
D	MSE260
D	NDP999

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PE4 A 1296

Chain	Residue
A	VAL159
A	ALA167
A	HIS170
A	NDP999

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PE4 B 1296

Chain	Residue
B	LEU64
B	MSE171
B	NDP999

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PE4 C 1296

Chain	Residue
C	ILE63
C	MSE171
C	MSE260
C	NDP999
C	HOH2026

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PE4 E 1296

Chain	Residue
E	LEU64
E	VAL159
E	ALA167
E	MSE260
E	NDP999

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PE4 F 1296

Chain	Residue
F	ILE63
F	VAL159
F	MSE260
F	NDP999
F	HOH2016

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PE4 G 1295

Chain	Residue
G	ILE63
G	LEU64
G	VAL159
G	MSE171
G	NDP999
G	HOH2018

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PE4 H 1296

Chain	Residue
H	ILE63
H	VAL159
H	MSE260
H	NDP999
H	HOH2010

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"AUG-2012","submissionDatabase":"PDB data bank","title":"Crystal structure of human epimerase family protein SDR39U1 (isoform2) with NADPH.","authoringGroup":["Structural genomics consortium (SGC)"]}},{"source":"PDB","id":"4B4O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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PDB entries from 2026-01-14

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