4AY2

Capturing 5' tri-phosphorylated RNA duplex by RIG-I

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0005524	molecular_function	ATP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1923

Chain	Residue
A	CYS810
A	CYS813
A	CYS864
A	CYS869

---

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE ADP A 1924

Chain	Residue
A	CYS268
A	GLY269
A	LYS270
A	THR271
A	MG1925
A	LYS242
A	ARG244
A	GLN247
A	THR266
A	GLY267

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG A 1925

Chain	Residue
A	THR271
A	ASP372
A	ADP1924

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: BINDING => ECO:0000305

Chain	Residue	Details
A	ALA264

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01125

Chain	Residue	Details
A	CYS810
A	CYS813
A	CYS864
A	CYS869

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: (Microbial infection) Deamidated asparagine; by herpes simplex virus 1/HHV-1 UL37 => ECO:0000269|PubMed:27866900

Chain	Residue	Details
A	ASN495
A	ASN549

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by CK2 => ECO:0000269|PubMed:21068236

Chain	Residue	Details
A	THR770

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine; by CK2 => ECO:0000269|PubMed:21068236

Chain	Residue	Details
A	SER854
A	SER855

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS858

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q6Q899

Chain	Residue	Details
A	LYS812

---