4AVX

Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate (Hgs-Hrs) bound to an IP2 compound at 1.68 A Resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0035091	molecular_function	phosphatidylinositol binding
A	0043130	molecular_function	ubiquitin binding
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 1224

Chain	Residue
A	ASP162
A	ALA163
A	GLU164
A	LYS179

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1225

Chain	Residue
A	CYS182
A	CYS185
A	CYS212
A	CYS215

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1226

Chain	Residue
A	CYS169
A	CYS190
A	CYS193
A	CYS166

---

site_id	AC4
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ITP A 1227

Chain	Residue
A	TRP160
A	ARG178
A	LYS179
A	HIS180
A	HIS181
A	ARG183
A	ARG210
A	EDO1233
A	HOH2127
A	HOH2128
A	HOH2129
A	HOH2133
A	HOH2144
A	HOH2145
A	HOH2147
A	HOH2148

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 1228

Chain	Residue
A	VAL102
A	ARG105
A	ASN106
A	EDO1232

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 1229

Chain	Residue
A	PRO214
A	CYS215

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 1230

Chain	Residue
A	LYS50
A	ASN54
A	GLU91
A	HOH2044

---

site_id	AC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EDO A 1231

Chain	Residue
A	GLN18

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1232

Chain	Residue
A	ARG105
A	LEU109
A	GLY139
A	HIS140
A	VAL141
A	EDO1228

---

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1233

Chain	Residue
A	ASP162
A	LYS179
A	HIS181
A	ILE188
A	GLU217
A	ITP1227

---

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 1234

Chain	Residue
A	GLN41
A	TYR44

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	128
Details	Domain: {"description":"VHS","evidences":[{"source":"PROSITE-ProRule","id":"PRU00218","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	60
Details	Zinc finger: {"description":"FYVE-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00091","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00091","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---