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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4AUO

Crystal structure of MMP-1(E200A) in complex with a triple-helical collagen peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0006508	biological_process	proteolysis
A	0008237	molecular_function	metallopeptidase activity
A	0008270	molecular_function	zinc ion binding
A	0031012	cellular_component	extracellular matrix
B	0004222	molecular_function	metalloendopeptidase activity
B	0006508	biological_process	proteolysis
B	0008237	molecular_function	metallopeptidase activity
B	0008270	molecular_function	zinc ion binding
B	0031012	cellular_component	extracellular matrix

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A 1101

Chain	Residue
A	ASP105
A	ARG146
A	GLU180
A	GLU182

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A 1102

Chain	Residue
A	ASP266
A	GLU310
A	ASP359
A	ASP408

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A 1103

Chain	Residue
A	GLY171
A	GLY173
A	ASP175
A	ASP139

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 1104

Chain	Residue
A	ASP156
A	GLY157
A	GLY159
A	ASN161
A	ASP179
A	GLU182

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1201

Chain	Residue
A	HIS149
A	ASP151
A	HIS164
A	HIS177

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN A 1202

Chain	Residue
A	HIS199
A	HIS203
A	HIS209

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA B 1101

Chain	Residue
B	ASP105
B	GLU180
B	GLU182

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA B 1102

Chain	Residue
B	ASP266
B	GLU310
B	ASP359
B	ASP408

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA B 1103

Chain	Residue
B	ASP139
B	GLY171
B	GLY173
B	ASP175

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 1104

Chain	Residue
B	ASP156
B	GLY157
B	GLY159
B	ASN161
B	ASP179
B	GLU182

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 1201

Chain	Residue
B	HIS149
B	ASP151
B	HIS164
B	HIS177

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN B 1202

Chain	Residue
B	HIS199
B	HIS203
B	HIS209

Functional Information from PROSITE/UniProt

site_id	PS00024
Number of Residues	16
Details	HEMOPEXIN Hemopexin domain signature. ISvfWpqlPnGLEAAY

Chain	Residue	Details
A	ILE298-TYR313

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE:

Chain	Residue	Details
A	ALA200
B	ALA200

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:8031754, ECO:0007744\|PDB:1CGE, ECO:0007744\|PDB:1CGF, ECO:0007744\|PDB:1SU3, ECO:0007744\|PDB:2CLT, ECO:0007744\|PDB:2J0T, ECO:0007744\|PDB:3SHI, ECO:0007744\|PDB:966C

Chain	Residue	Details
A	ASP105
B	ASP105

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269\|PubMed:15611040, ECO:0000269\|PubMed:7656013, ECO:0000269\|PubMed:8031754, ECO:0007744\|PDB:1CGE, ECO:0007744\|PDB:1CGF, ECO:0007744\|PDB:1SU3, ECO:0007744\|PDB:2CLT, ECO:0007744\|PDB:2J0T, ECO:0007744\|PDB:2TCL, ECO:0007744\|PDB:4AUO, ECO:0007744\|PDB:966C

Chain	Residue	Details
A	ASP139
A	GLY171
A	ASP175
B	ASP139
B	GLY171
B	ASP175

site_id	SWS_FT_FI4
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269\|PubMed:15611040, ECO:0000269\|PubMed:7656013, ECO:0000269\|PubMed:8031754, ECO:0000269\|PubMed:8090713, ECO:0000269\|PubMed:8278810, ECO:0000269\|PubMed:9484219, ECO:0007744\|PDB:1AYK, ECO:0007744\|PDB:1CGE, ECO:0007744\|PDB:1CGF, ECO:0007744\|PDB:1CGL, ECO:0007744\|PDB:1HFC, ECO:0007744\|PDB:1SU3, ECO:0007744\|PDB:2AYK, ECO:0007744\|PDB:2CLT, ECO:0007744\|PDB:2J0T, ECO:0007744\|PDB:2TCL, ECO:0007744\|PDB:3AYK, ECO:0007744\|PDB:3SHI, ECO:0007744\|PDB:4AUO, ECO:0007744\|PDB:4AYK, ECO:0007744\|PDB:966C

Chain	Residue	Details
A	HIS149
B	HIS199
B	HIS203
B	HIS209
A	HIS164
A	HIS177
A	HIS199
A	HIS203
A	HIS209
B	HIS149
B	HIS164
B	HIS177

site_id	SWS_FT_FI5
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:15611040, ECO:0000269\|PubMed:7656013, ECO:0000269\|PubMed:8031754, ECO:0000269\|PubMed:8090713, ECO:0000269\|PubMed:8278810, ECO:0000269\|PubMed:9484219, ECO:0007744\|PDB:1CGE, ECO:0007744\|PDB:1CGF, ECO:0007744\|PDB:1CGL, ECO:0007744\|PDB:1HFC, ECO:0007744\|PDB:1SU3, ECO:0007744\|PDB:2AYK, ECO:0007744\|PDB:2CLT, ECO:0007744\|PDB:2J0T, ECO:0007744\|PDB:2TCL, ECO:0007744\|PDB:3SHI, ECO:0007744\|PDB:4AUO, ECO:0007744\|PDB:966C

Chain	Residue	Details
A	ASP151
B	ASP151

site_id	SWS_FT_FI6
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:15611040, ECO:0000269\|PubMed:7656013, ECO:0000269\|PubMed:8031754, ECO:0000269\|PubMed:8090713, ECO:0000269\|PubMed:8278810, ECO:0007744\|PDB:1CGE, ECO:0007744\|PDB:1CGF, ECO:0007744\|PDB:1CGL, ECO:0007744\|PDB:1HFC, ECO:0007744\|PDB:1SU3, ECO:0007744\|PDB:2CLT, ECO:0007744\|PDB:2J0T, ECO:0007744\|PDB:2TCL, ECO:0007744\|PDB:3SHI, ECO:0007744\|PDB:4AUO, ECO:0007744\|PDB:966C

Chain	Residue	Details
A	ASP156
B	ASP156

site_id	SWS_FT_FI7
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:15611040, ECO:0000269\|PubMed:7656013, ECO:0000269\|PubMed:8031754, ECO:0000269\|PubMed:8090713, ECO:0000269\|PubMed:8278810, ECO:0000269\|PubMed:9484219, ECO:0007744\|PDB:1AYK, ECO:0007744\|PDB:1CGE, ECO:0007744\|PDB:1CGF, ECO:0007744\|PDB:1CGL, ECO:0007744\|PDB:1HFC, ECO:0007744\|PDB:1SU3, ECO:0007744\|PDB:2AYK, ECO:0007744\|PDB:2CLT, ECO:0007744\|PDB:2J0T, ECO:0007744\|PDB:2TCL, ECO:0007744\|PDB:3SHI, ECO:0007744\|PDB:4AUO, ECO:0007744\|PDB:4AYK, ECO:0007744\|PDB:966C

Chain	Residue	Details
A	GLY157
B	GLY157

site_id	SWS_FT_FI8
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:15611040, ECO:0000269\|PubMed:7656013, ECO:0000269\|PubMed:8031754, ECO:0000269\|PubMed:8090713, ECO:0000269\|PubMed:8278810, ECO:0000269\|PubMed:9484219, ECO:0007744\|PDB:1AYK, ECO:0007744\|PDB:1CGE, ECO:0007744\|PDB:1CGF, ECO:0007744\|PDB:1CGL, ECO:0007744\|PDB:1HFC, ECO:0007744\|PDB:1SU3, ECO:0007744\|PDB:2AYK, ECO:0007744\|PDB:2CLT, ECO:0007744\|PDB:2J0T, ECO:0007744\|PDB:2TCL, ECO:0007744\|PDB:3SHI, ECO:0007744\|PDB:4AUO, ECO:0007744\|PDB:966C

Chain	Residue	Details
A	GLY159
A	ASN161
B	GLY159
B	ASN161

site_id	SWS_FT_FI9
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:7656013, ECO:0000269\|PubMed:8031754, ECO:0007744\|PDB:1CGE, ECO:0007744\|PDB:1CGF, ECO:0007744\|PDB:2CLT, ECO:0007744\|PDB:2J0T, ECO:0007744\|PDB:2TCL, ECO:0007744\|PDB:4AUO, ECO:0007744\|PDB:966C

Chain	Residue	Details
A	GLY173
B	GLY173

site_id	SWS_FT_FI10
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:15611040, ECO:0000269\|PubMed:7656013, ECO:0000269\|PubMed:8031754, ECO:0000269\|PubMed:8090713, ECO:0000269\|PubMed:8278810, ECO:0007744\|PDB:1CGE, ECO:0007744\|PDB:1CGF, ECO:0007744\|PDB:1CGL, ECO:0007744\|PDB:1HFC, ECO:0007744\|PDB:1SU3, ECO:0007744\|PDB:2CLT, ECO:0007744\|PDB:2J0T, ECO:0007744\|PDB:2TCL, ECO:0007744\|PDB:3AYK, ECO:0007744\|PDB:3SHI, ECO:0007744\|PDB:4AUO, ECO:0007744\|PDB:4AYK, ECO:0007744\|PDB:966C

Chain	Residue	Details
A	ASP179
B	ASP179

site_id	SWS_FT_FI11
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:15611040, ECO:0000269\|PubMed:8031754, ECO:0007744\|PDB:1CGE, ECO:0007744\|PDB:1CGF, ECO:0007744\|PDB:1SU3, ECO:0007744\|PDB:2CLT, ECO:0007744\|PDB:2J0T, ECO:0007744\|PDB:3SHI, ECO:0007744\|PDB:4AUO, ECO:0007744\|PDB:966C

Chain	Residue	Details
A	GLU180
B	GLU180

site_id	SWS_FT_FI12
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:15611040, ECO:0000269\|PubMed:7656013, ECO:0000269\|PubMed:8031754, ECO:0000269\|PubMed:8090713, ECO:0000269\|PubMed:8278810, ECO:0000269\|PubMed:9484219, ECO:0007744\|PDB:1AYK, ECO:0007744\|PDB:1CGE, ECO:0007744\|PDB:1CGF, ECO:0007744\|PDB:1CGL, ECO:0007744\|PDB:1HFC, ECO:0007744\|PDB:1SU3, ECO:0007744\|PDB:2AYK, ECO:0007744\|PDB:2CLT, ECO:0007744\|PDB:2J0T, ECO:0007744\|PDB:2TCL, ECO:0007744\|PDB:3AYK, ECO:0007744\|PDB:3SHI, ECO:0007744\|PDB:4AUO, ECO:0007744\|PDB:966C

Chain	Residue	Details
A	GLU182
B	GLU182

site_id	SWS_FT_FI13
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269\|PubMed:15611040, ECO:0007744\|PDB:1SU3, ECO:0007744\|PDB:2CLT, ECO:0007744\|PDB:4AUO

Chain	Residue	Details
A	ASP266
A	GLU310
A	ASP359
A	ASP408
B	ASP266
B	GLU310
B	ASP359
B	ASP408

site_id	SWS_FT_FI14
Number of Residues	2
Details	SITE: Not glycosylated => ECO:0000269\|PubMed:10092871

Chain	Residue	Details
A	ASN124
B	ASN124

site_id	SWS_FT_FI15
Number of Residues	2
Details	SITE: Cleavage; by autolysis => ECO:0000269\|PubMed:2557822

Chain	Residue	Details
A	PRO250
B	PRO250

site_id	SWS_FT_FI16
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000269\|PubMed:25171405

Chain	Residue	Details
A	THR255
B	THR255

site_id	SWS_FT_FI17
Number of Residues	2
Details	MOD_RES: Phosphotyrosine; by PKDCC => ECO:0000269\|PubMed:25171405

Chain	Residue	Details
A	TYR341
B	TYR341

site_id	SWS_FT_FI18
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:10092871

Chain	Residue	Details
A	ASN101
B	ASN101

222415

PDB entries from 2024-07-10

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