4AU7
The structure of the Suv4-20h2 ternary complex with histone H4
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE SAH A 1247 |
| Chain | Residue |
| A | HIS32 |
| A | TYR217 |
| A | PHE222 |
| A | CYS229 |
| A | GLU230 |
| A | CYS231 |
| A | EDO1251 |
| A | HOH2015 |
| A | HOH2053 |
| C | MLY20 |
| A | TYR114 |
| A | GLU117 |
| A | GLY120 |
| A | ALA121 |
| A | PHE160 |
| A | ALA179 |
| A | ASN182 |
| A | HIS183 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1248 |
| Chain | Residue |
| A | CYS185 |
| A | CYS229 |
| A | CYS231 |
| A | CYS234 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1249 |
| Chain | Residue |
| A | HIS92 |
| A | CYS95 |
| A | CYS141 |
| A | HOH2033 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO A 1250 |
| Chain | Residue |
| A | ALA99 |
| A | PHE100 |
| A | LEU101 |
| A | PRO102 |
| A | SER104 |
| A | GLY105 |
| A | PHE106 |
| A | THR126 |
| A | EDO1257 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 1251 |
| Chain | Residue |
| A | TYR114 |
| A | SER115 |
| A | MET116 |
| A | GLU230 |
| A | SAH1247 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 1252 |
| Chain | Residue |
| A | CYS95 |
| A | ARG98 |
| A | ALA99 |
| A | LEU137 |
| A | VAL139 |
| A | HOH2034 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 1253 |
| Chain | Residue |
| A | PHE29 |
| A | ARG30 |
| A | ASN119 |
| A | HOH2013 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 1254 |
| Chain | Residue |
| A | ASP24 |
| A | GLY28 |
| A | PHE29 |
| A | ARG30 |
| A | GLN45 |
| A | HOH2012 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 1255 |
| Chain | Residue |
| A | GLU150 |
| A | LEU153 |
| C | ARG19 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 1256 |
| Chain | Residue |
| A | THR91 |
| A | ARG98 |
| A | HOH2031 |
| A | HOH2032 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 1257 |
| Chain | Residue |
| A | PRO102 |
| A | GLY105 |
| A | THR126 |
| A | ARG127 |
| A | EDO1250 |
| A | HOH2036 |
| site_id | BC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE ZN B 1219 |
| Chain | Residue |
| B | CYS185 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 1220 |
| Chain | Residue |
| B | ASP16 |
| B | VAL36 |
| B | SER37 |
| B | PRO38 |
| B | TYR77 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 1221 |
| Chain | Residue |
| B | LEU42 |
| B | ARG43 |
| B | GLN45 |
| B | LEU48 |
| B | HOH2004 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 1222 |
| Chain | Residue |
| B | TYR26 |
| B | ARG49 |
| B | ARG59 |
| B | LEU101 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 1223 |
| Chain | Residue |
| B | PRO187 |
| B | CYS189 |
| B | LYS190 |
| B | PHE191 |
| B | CYS215 |
| B | PHE216 |
| site_id | BC8 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE EDO B 1224 |
| Chain | Residue |
| B | LEU137 |
| B | HIS46 |
| B | ARG49 |
| B | SER50 |
| B | GLU103 |
| B | SER104 |
| B | PHE106 |
| B | TRP129 |
| B | LEU135 |
| B | GLU136 |
| site_id | BC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 1225 |
| Chain | Residue |
| B | ASP60 |
| B | ALA63 |
| B | ARG66 |
| site_id | CC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 1226 |
| Chain | Residue |
| B | ASP60 |
| B | LEU61 |
| B | GLU62 |
| B | VAL124 |
| B | SER125 |
| B | HOH2020 |
| site_id | CC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 1227 |
| Chain | Residue |
| B | GLU117 |
| B | ALA121 |
| B | ASN182 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 114 |
| Details | Domain: {"description":"SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Region: {"description":"Histone H4 binding","evidences":[{"source":"PubMed","id":"24049080","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4AU7","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 11 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24049080","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4AU7","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"4AU7","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q86Y97","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Site: {"description":"Histone H4 binding; via carbonyl oxygen","evidences":[{"source":"PubMed","id":"24049080","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4AU7","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62803","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
