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4AD7

Crystal structure of full-length N-glycosylated human glypican-1

Functional Information from GO Data
ChainGOidnamespacecontents
A0005507molecular_functioncopper ion binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005654cellular_componentnucleoplasm
A0005768cellular_componentendosome
A0005796cellular_componentGolgi lumen
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0009966biological_processregulation of signal transduction
A0009986cellular_componentcell surface
A0014037biological_processSchwann cell differentiation
A0016477biological_processcell migration
A0017134molecular_functionfibroblast growth factor binding
A0030200biological_processheparan sulfate proteoglycan catabolic process
A0031012cellular_componentextracellular matrix
A0032288biological_processmyelin assembly
A0040037biological_processnegative regulation of fibroblast growth factor receptor signaling pathway
A0043202cellular_componentlysosomal lumen
A0043236molecular_functionlaminin binding
A0045121cellular_componentmembrane raft
A0045202cellular_componentsynapse
A0062023cellular_componentcollagen-containing extracellular matrix
A0070062cellular_componentextracellular exosome
A0098552cellular_componentside of membrane
A1905475biological_processregulation of protein localization to membrane
A2001016biological_processpositive regulation of skeletal muscle cell differentiation
B0005507molecular_functioncopper ion binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005654cellular_componentnucleoplasm
B0005768cellular_componentendosome
B0005796cellular_componentGolgi lumen
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0009966biological_processregulation of signal transduction
B0009986cellular_componentcell surface
B0014037biological_processSchwann cell differentiation
B0016477biological_processcell migration
B0017134molecular_functionfibroblast growth factor binding
B0030200biological_processheparan sulfate proteoglycan catabolic process
B0031012cellular_componentextracellular matrix
B0032288biological_processmyelin assembly
B0040037biological_processnegative regulation of fibroblast growth factor receptor signaling pathway
B0043202cellular_componentlysosomal lumen
B0043236molecular_functionlaminin binding
B0045121cellular_componentmembrane raft
B0045202cellular_componentsynapse
B0062023cellular_componentcollagen-containing extracellular matrix
B0070062cellular_componentextracellular exosome
B0098552cellular_componentside of membrane
B1905475biological_processregulation of protein localization to membrane
B2001016biological_processpositive regulation of skeletal muscle cell differentiation
C0005507molecular_functioncopper ion binding
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005654cellular_componentnucleoplasm
C0005768cellular_componentendosome
C0005796cellular_componentGolgi lumen
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0009966biological_processregulation of signal transduction
C0009986cellular_componentcell surface
C0014037biological_processSchwann cell differentiation
C0016477biological_processcell migration
C0017134molecular_functionfibroblast growth factor binding
C0030200biological_processheparan sulfate proteoglycan catabolic process
C0031012cellular_componentextracellular matrix
C0032288biological_processmyelin assembly
C0040037biological_processnegative regulation of fibroblast growth factor receptor signaling pathway
C0043202cellular_componentlysosomal lumen
C0043236molecular_functionlaminin binding
C0045121cellular_componentmembrane raft
C0045202cellular_componentsynapse
C0062023cellular_componentcollagen-containing extracellular matrix
C0070062cellular_componentextracellular exosome
C0098552cellular_componentside of membrane
C1905475biological_processregulation of protein localization to membrane
C2001016biological_processpositive regulation of skeletal muscle cell differentiation
D0005507molecular_functioncopper ion binding
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005654cellular_componentnucleoplasm
D0005768cellular_componentendosome
D0005796cellular_componentGolgi lumen
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0009966biological_processregulation of signal transduction
D0009986cellular_componentcell surface
D0014037biological_processSchwann cell differentiation
D0016477biological_processcell migration
D0017134molecular_functionfibroblast growth factor binding
D0030200biological_processheparan sulfate proteoglycan catabolic process
D0031012cellular_componentextracellular matrix
D0032288biological_processmyelin assembly
D0040037biological_processnegative regulation of fibroblast growth factor receptor signaling pathway
D0043202cellular_componentlysosomal lumen
D0043236molecular_functionlaminin binding
D0045121cellular_componentmembrane raft
D0045202cellular_componentsynapse
D0062023cellular_componentcollagen-containing extracellular matrix
D0070062cellular_componentextracellular exosome
D0098552cellular_componentside of membrane
D1905475biological_processregulation of protein localization to membrane
D2001016biological_processpositive regulation of skeletal muscle cell differentiation
Functional Information from PROSITE/UniProt
site_idPS01207
Number of Residues24
DetailsGLYPICAN Glypicans signature. CahClGVpgarPCpdYCrnVlkGC
ChainResidueDetails
ACYS256-CYS279

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21932778, ECO:0000269|PubMed:22351761
ChainResidueDetails
AASN79
BASN79
CASN79
DASN79

site_idSWS_FT_FI2
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2148568, ECO:0000269|PubMed:21932778, ECO:0000269|PubMed:22351761
ChainResidueDetails
AASN116
BASN116
CASN116
DASN116

site_idSWS_FT_FI3
Number of Residues12
DetailsCARBOHYD: O-linked (Xyl...) (heparan sulfate) serine => ECO:0000305
ChainResidueDetails
ASER486
DSER486
DSER488
DSER490
ASER488
ASER490
BSER486
BSER488
BSER490
CSER486
CSER488
CSER490

227344

PDB entries from 2024-11-13

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