4ABO
Mal3 CH domain homology model and mammalian tubulin (2XRP) docked into the 8.6-Angstrom cryo-EM map of Mal3-GTPgammaS-microtubules
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000226 | biological_process | microtubule cytoskeleton organization |
| A | 0000278 | biological_process | mitotic cell cycle |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005200 | molecular_function | structural constituent of cytoskeleton |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005856 | cellular_component | cytoskeleton |
| A | 0005874 | cellular_component | microtubule |
| A | 0007017 | biological_process | microtubule-based process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000226 | biological_process | microtubule cytoskeleton organization |
| B | 0000278 | biological_process | mitotic cell cycle |
| B | 0005200 | molecular_function | structural constituent of cytoskeleton |
| B | 0005525 | molecular_function | GTP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005856 | cellular_component | cytoskeleton |
| B | 0005874 | cellular_component | microtubule |
| B | 0007017 | biological_process | microtubule-based process |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0000226 | biological_process | microtubule cytoskeleton organization |
| C | 0000278 | biological_process | mitotic cell cycle |
| C | 0003924 | molecular_function | GTPase activity |
| C | 0005200 | molecular_function | structural constituent of cytoskeleton |
| C | 0005515 | molecular_function | protein binding |
| C | 0005525 | molecular_function | GTP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005856 | cellular_component | cytoskeleton |
| C | 0005874 | cellular_component | microtubule |
| C | 0007017 | biological_process | microtubule-based process |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0000226 | biological_process | microtubule cytoskeleton organization |
| D | 0000278 | biological_process | mitotic cell cycle |
| D | 0005200 | molecular_function | structural constituent of cytoskeleton |
| D | 0005525 | molecular_function | GTP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005856 | cellular_component | cytoskeleton |
| D | 0005874 | cellular_component | microtubule |
| D | 0007017 | biological_process | microtubule-based process |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0046872 | molecular_function | metal ion binding |
| E | 0000226 | biological_process | microtubule cytoskeleton organization |
| E | 0000278 | biological_process | mitotic cell cycle |
| E | 0003924 | molecular_function | GTPase activity |
| E | 0005200 | molecular_function | structural constituent of cytoskeleton |
| E | 0005515 | molecular_function | protein binding |
| E | 0005525 | molecular_function | GTP binding |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005856 | cellular_component | cytoskeleton |
| E | 0005874 | cellular_component | microtubule |
| E | 0007017 | biological_process | microtubule-based process |
| E | 0046872 | molecular_function | metal ion binding |
| F | 0000226 | biological_process | microtubule cytoskeleton organization |
| F | 0000278 | biological_process | mitotic cell cycle |
| F | 0005200 | molecular_function | structural constituent of cytoskeleton |
| F | 0005525 | molecular_function | GTP binding |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005856 | cellular_component | cytoskeleton |
| F | 0005874 | cellular_component | microtubule |
| F | 0007017 | biological_process | microtubule-based process |
| F | 0016787 | molecular_function | hydrolase activity |
| F | 0046872 | molecular_function | metal ion binding |
| G | 0000226 | biological_process | microtubule cytoskeleton organization |
| G | 0000278 | biological_process | mitotic cell cycle |
| G | 0003924 | molecular_function | GTPase activity |
| G | 0005200 | molecular_function | structural constituent of cytoskeleton |
| G | 0005515 | molecular_function | protein binding |
| G | 0005525 | molecular_function | GTP binding |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0005856 | cellular_component | cytoskeleton |
| G | 0005874 | cellular_component | microtubule |
| G | 0007017 | biological_process | microtubule-based process |
| G | 0046872 | molecular_function | metal ion binding |
| H | 0000226 | biological_process | microtubule cytoskeleton organization |
| H | 0000278 | biological_process | mitotic cell cycle |
| H | 0005200 | molecular_function | structural constituent of cytoskeleton |
| H | 0005525 | molecular_function | GTP binding |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0005856 | cellular_component | cytoskeleton |
| H | 0005874 | cellular_component | microtubule |
| H | 0007017 | biological_process | microtubule-based process |
| H | 0016787 | molecular_function | hydrolase activity |
| H | 0046872 | molecular_function | metal ion binding |
| I | 0008017 | molecular_function | microtubule binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE GSP C 1438 |
| Chain | Residue |
| B | GLU254 |
| C | SER140 |
| C | GLY142 |
| C | GLY144 |
| C | THR145 |
| C | GLY146 |
| C | ASP179 |
| C | GLU183 |
| C | ASN206 |
| C | TYR224 |
| C | ASN228 |
| C | GLY10 |
| C | GLN11 |
| C | CYS12 |
| C | GLN15 |
| C | GLU71 |
| C | ALA99 |
| C | GLY100 |
| C | ASN101 |
| site_id | AC2 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE GSP A 1438 |
| Chain | Residue |
| A | GLY10 |
| A | GLN11 |
| A | CYS12 |
| A | GLN15 |
| A | GLU71 |
| A | ALA99 |
| A | GLY100 |
| A | ASN101 |
| A | SER140 |
| A | GLY142 |
| A | GLY144 |
| A | THR145 |
| A | GLY146 |
| A | ASP179 |
| A | GLU183 |
| A | ASN206 |
| A | TYR224 |
| A | ASN228 |
| site_id | AC3 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE GTP B 500 |
| Chain | Residue |
| A | LEU248 |
| A | LYS254 |
| B | GLY10 |
| B | GLN11 |
| B | ALA12 |
| B | GLN15 |
| B | ALA99 |
| B | ALA100 |
| B | ASN101 |
| B | SER140 |
| B | GLY143 |
| B | GLY144 |
| B | THR145 |
| B | GLY146 |
| B | ILE171 |
| B | GLU183 |
| B | ASN206 |
| B | TYR224 |
| B | ASN228 |
| site_id | AC4 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE GSP E 1438 |
| Chain | Residue |
| E | GLY10 |
| E | GLN11 |
| E | CYS12 |
| E | GLN15 |
| E | GLU71 |
| E | ALA99 |
| E | GLY100 |
| E | ASN101 |
| E | SER140 |
| E | GLY142 |
| E | GLY144 |
| E | THR145 |
| E | GLY146 |
| E | ASP179 |
| E | GLU183 |
| E | ASN206 |
| E | TYR224 |
| E | ASN228 |
| site_id | AC5 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE GTP D 500 |
| Chain | Residue |
| C | LEU248 |
| C | LYS254 |
| D | GLY10 |
| D | GLN11 |
| D | ALA12 |
| D | GLN15 |
| D | ALA99 |
| D | ALA100 |
| D | ASN101 |
| D | SER140 |
| D | GLY143 |
| D | GLY144 |
| D | THR145 |
| D | GLY146 |
| D | ILE171 |
| D | GLU183 |
| D | ASN206 |
| D | TYR224 |
| D | ASN228 |
| site_id | AC6 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE GTP F 500 |
| Chain | Residue |
| F | ALA99 |
| F | ALA100 |
| F | ASN101 |
| F | SER140 |
| F | GLY143 |
| F | GLY144 |
| F | THR145 |
| F | GLY146 |
| F | ILE171 |
| F | GLU183 |
| F | ASN206 |
| F | TYR224 |
| F | ASN228 |
| E | LEU248 |
| E | LYS254 |
| F | GLY10 |
| F | GLN11 |
| F | ALA12 |
| F | GLN15 |
| site_id | AC7 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE GTP H 500 |
| Chain | Residue |
| G | LEU248 |
| H | GLY10 |
| H | GLN11 |
| H | ALA12 |
| H | GLN15 |
| H | ALA99 |
| H | ALA100 |
| H | ASN101 |
| H | SER140 |
| H | GLY143 |
| H | GLY144 |
| H | THR145 |
| H | GLY146 |
| H | ILE171 |
| H | GLU183 |
| H | ASN206 |
| H | TYR224 |
| H | ASN228 |
| site_id | AC8 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE GSP G 1438 |
| Chain | Residue |
| F | GLU254 |
| G | GLY10 |
| G | GLN11 |
| G | CYS12 |
| G | GLN15 |
| G | GLU71 |
| G | ALA99 |
| G | GLY100 |
| G | ASN101 |
| G | SER140 |
| G | GLY142 |
| G | GLY144 |
| G | THR145 |
| G | GLY146 |
| G | ASP179 |
| G | GLU183 |
| G | ASN206 |
| G | TYR224 |
| G | ASN228 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:P68363 |
| Chain | Residue | Details |
| B | GLU254 | |
| C | GLY144 | |
| C | THR145 | |
| C | GLY146 | |
| C | ASN206 | |
| C | ASN228 | |
| E | GLN11 | |
| E | SER140 | |
| E | GLY144 | |
| E | THR145 | |
| E | GLY146 | |
| D | GLU254 | |
| E | ASN206 | |
| E | ASN228 | |
| G | GLN11 | |
| G | SER140 | |
| G | GLY144 | |
| G | THR145 | |
| G | GLY146 | |
| G | ASN206 | |
| G | ASN228 | |
| F | GLU254 | |
| H | GLU254 | |
| A | GLY146 | |
| A | ASN206 | |
| A | ASN228 | |
| C | GLN11 | |
| C | SER140 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 32 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P68363 |
| Chain | Residue | Details |
| B | GLN11 | |
| D | GLU71 | |
| D | SER140 | |
| D | GLY144 | |
| D | THR145 | |
| D | THR179 | |
| D | ASN206 | |
| D | ASN228 | |
| F | GLN11 | |
| F | GLU71 | |
| F | SER140 | |
| B | GLU71 | |
| F | GLY144 | |
| F | THR145 | |
| F | THR179 | |
| F | ASN206 | |
| F | ASN228 | |
| H | GLN11 | |
| H | GLU71 | |
| H | SER140 | |
| H | GLY144 | |
| H | THR145 | |
| B | SER140 | |
| H | THR179 | |
| H | ASN206 | |
| H | ASN228 | |
| B | GLY144 | |
| B | THR145 | |
| B | THR179 | |
| B | ASN206 | |
| B | ASN228 | |
| D | GLN11 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | SITE: Involved in polymerization |
| Chain | Residue | Details |
| B | TYR451 | |
| D | TYR451 | |
| F | TYR451 | |
| H | TYR451 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q71U36 |
| Chain | Residue | Details |
| B | LYS40 | |
| D | LYS40 | |
| F | LYS40 | |
| H | LYS40 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | MOD_RES: 3'-nitrotyrosine => ECO:0000250|UniProtKB:P68373 |
| Chain | Residue | Details |
| B | TYR282 | |
| D | TYR282 | |
| F | TYR282 | |
| H | TYR282 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P68373 |
| Chain | Residue | Details |
| B | SER439 | |
| D | SER439 | |
| F | SER439 | |
| H | SER439 | |
| E | THR287 | |
| E | THR292 | |
| G | THR287 | |
| G | THR292 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | MOD_RES: 5-glutamyl polyglutamate => ECO:0000250|UniProtKB:Q71U36 |
| Chain | Residue | Details |
| B | GLU443 | |
| D | GLU443 | |
| F | GLU443 | |
| H | GLU443 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | MOD_RES: 5-glutamyl polyglutamate => ECO:0000250|UniProtKB:P68369 |
| Chain | Residue | Details |
| B | GLU445 | |
| D | GLU445 | |
| F | GLU445 | |
| H | GLU445 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | MOD_RES: 3'-nitrotyrosine => ECO:0000250|UniProtKB:Q71U36 |
| Chain | Residue | Details |
| B | TYR451 | |
| D | TYR451 | |
| F | TYR451 | |
| H | TYR451 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P07437 |
| Chain | Residue | Details |
| A | LYS326 | |
| C | LYS326 | |
| E | LYS326 | |
| G | LYS326 |
