4AAP
Crystal structure of JMJD5 domain of human Lysine-specific demethylase 8 (KDM8) in complex with N-oxalylglycine (NOG)
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 500 |
| Chain | Residue |
| A | HIS359 |
| A | ASP361 |
| A | HIS438 |
| A | OGA501 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE OGA A 501 |
| Chain | Residue |
| A | ASN365 |
| A | LYS374 |
| A | HIS438 |
| A | VAL440 |
| A | ZN500 |
| A | TYR310 |
| A | TRP348 |
| A | SER356 |
| A | HIS359 |
| A | ASP361 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN A 502 |
| Chain | Residue |
| A | HIS252 |
| A | ASP283 |
| A | HIS393 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 500 |
| Chain | Residue |
| B | HIS359 |
| B | ASP361 |
| B | HIS438 |
| B | OGA501 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE OGA B 501 |
| Chain | Residue |
| B | TYR310 |
| B | TRP348 |
| B | SER356 |
| B | HIS359 |
| B | ASP361 |
| B | ASN365 |
| B | LYS374 |
| B | HIS438 |
| B | VAL440 |
| B | TRP452 |
| B | ZN500 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN B 502 |
| Chain | Residue |
| B | HIS252 |
| B | ASP283 |
| B | HIS393 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:29459673 |
| Chain | Residue | Details |
| A | LEU238 | |
| A | VAL275 | |
| A | ASP318 | |
| B | LEU238 | |
| B | VAL275 | |
| B | ASP318 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22851697, ECO:0000269|PubMed:29459673, ECO:0000269|PubMed:29563586, ECO:0000305|PubMed:24100311, ECO:0007744|PDB:3UYJ, ECO:0007744|PDB:4GJZ, ECO:0007744|PDB:4QU1, ECO:0007744|PDB:5FBJ |
| Chain | Residue | Details |
| A | THR272 | |
| A | ILE327 | |
| A | GLY336 | |
| B | THR272 | |
| B | ILE327 | |
| B | GLY336 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000305|PubMed:22851697, ECO:0000305|PubMed:24100311, ECO:0007744|PDB:4GJY, ECO:0007744|PDB:4GJZ |
| Chain | Residue | Details |
| A | PRO321 | |
| A | LEU323 | |
| A | GLN400 | |
| B | PRO321 | |
| B | LEU323 | |
| B | GLN400 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22851697, ECO:0000269|PubMed:29459673, ECO:0000269|PubMed:29563586, ECO:0007744|PDB:3UYJ, ECO:0007744|PDB:4GJZ |
| Chain | Residue | Details |
| A | PHE414 | |
| B | PHE414 |
