4AAP
Crystal structure of JMJD5 domain of human Lysine-specific demethylase 8 (KDM8) in complex with N-oxalylglycine (NOG)
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 500 |
| Chain | Residue |
| A | HIS359 |
| A | ASP361 |
| A | HIS438 |
| A | OGA501 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE OGA A 501 |
| Chain | Residue |
| A | ASN365 |
| A | LYS374 |
| A | HIS438 |
| A | VAL440 |
| A | ZN500 |
| A | TYR310 |
| A | TRP348 |
| A | SER356 |
| A | HIS359 |
| A | ASP361 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN A 502 |
| Chain | Residue |
| A | HIS252 |
| A | ASP283 |
| A | HIS393 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 500 |
| Chain | Residue |
| B | HIS359 |
| B | ASP361 |
| B | HIS438 |
| B | OGA501 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE OGA B 501 |
| Chain | Residue |
| B | TYR310 |
| B | TRP348 |
| B | SER356 |
| B | HIS359 |
| B | ASP361 |
| B | ASN365 |
| B | LYS374 |
| B | HIS438 |
| B | VAL440 |
| B | TRP452 |
| B | ZN500 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN B 502 |
| Chain | Residue |
| B | HIS252 |
| B | ASP283 |
| B | HIS393 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29459673","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22851697","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29459673","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29563586","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24100311","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3UYJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GJZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QU1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FBJ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"22851697","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24100311","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4GJY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GJZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22851697","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29459673","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29563586","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3UYJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GJZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
