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4AAP

Crystal structure of JMJD5 domain of human Lysine-specific demethylase 8 (KDM8) in complex with N-oxalylglycine (NOG)

Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 500
ChainResidue
AHIS359
AASP361
AHIS438
AOGA501

site_idAC2
Number of Residues10
DetailsBINDING SITE FOR RESIDUE OGA A 501
ChainResidue
AASN365
ALYS374
AHIS438
AVAL440
AZN500
ATYR310
ATRP348
ASER356
AHIS359
AASP361

site_idAC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE ZN A 502
ChainResidue
AHIS252
AASP283
AHIS393

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 500
ChainResidue
BHIS359
BASP361
BHIS438
BOGA501

site_idAC5
Number of Residues11
DetailsBINDING SITE FOR RESIDUE OGA B 501
ChainResidue
BTYR310
BTRP348
BSER356
BHIS359
BASP361
BASN365
BLYS374
BHIS438
BVAL440
BTRP452
BZN500

site_idAC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE ZN B 502
ChainResidue
BHIS252
BASP283
BHIS393

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:29459673
ChainResidueDetails
ALEU238
AVAL275
AASP318
BLEU238
BVAL275
BASP318

site_idSWS_FT_FI2
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:22851697, ECO:0000269|PubMed:29459673, ECO:0000269|PubMed:29563586, ECO:0000305|PubMed:24100311, ECO:0007744|PDB:3UYJ, ECO:0007744|PDB:4GJZ, ECO:0007744|PDB:4QU1, ECO:0007744|PDB:5FBJ
ChainResidueDetails
ATHR272
AILE327
AGLY336
BTHR272
BILE327
BGLY336

site_idSWS_FT_FI3
Number of Residues6
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000305|PubMed:22851697, ECO:0000305|PubMed:24100311, ECO:0007744|PDB:4GJY, ECO:0007744|PDB:4GJZ
ChainResidueDetails
APRO321
ALEU323
AGLN400
BPRO321
BLEU323
BGLN400

site_idSWS_FT_FI4
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:22851697, ECO:0000269|PubMed:29459673, ECO:0000269|PubMed:29563586, ECO:0007744|PDB:3UYJ, ECO:0007744|PDB:4GJZ
ChainResidueDetails
APHE414
BPHE414

229183

PDB entries from 2024-12-18

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