4A1O
Crystal structure of Mycobacterium tuberculosis PurH complexed with AICAR and a novel nucleotide CFAIR, at 2.48 A resolution.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0003937 | molecular_function | IMP cyclohydrolase activity |
| A | 0004643 | molecular_function | phosphoribosylaminoimidazolecarboxamide formyltransferase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006164 | biological_process | purine nucleotide biosynthetic process |
| A | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0003937 | molecular_function | IMP cyclohydrolase activity |
| B | 0004643 | molecular_function | phosphoribosylaminoimidazolecarboxamide formyltransferase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006164 | biological_process | purine nucleotide biosynthetic process |
| B | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016787 | molecular_function | hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K A 1524 |
| Chain | Residue |
| A | CYS421 |
| A | ARG422 |
| A | VAL424 |
| A | ASP470 |
| A | HIS520 |
| A | ALA522 |
| site_id | AC2 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE AMZ A 1525 |
| Chain | Residue |
| A | ASN259 |
| A | ASN260 |
| A | HIS284 |
| A | GLY314 |
| A | GLU337 |
| A | PO41527 |
| A | HOH2048 |
| A | HOH2049 |
| A | HOH2064 |
| A | HOH2085 |
| A | HOH2141 |
| A | HOH2142 |
| B | ASN427 |
| B | ARG447 |
| B | ALA471 |
| B | PHE472 |
| B | ARG519 |
| B | PHE521 |
| A | ARG224 |
| A | TYR225 |
| A | SER257 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 A 1526 |
| Chain | Residue |
| A | ASN427 |
| A | VAL445 |
| A | ASN446 |
| A | ARG447 |
| B | LYS283 |
| B | AMZ1525 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 A 1527 |
| Chain | Residue |
| A | LYS283 |
| A | AMZ1525 |
| A | HOH2084 |
| B | ASN427 |
| B | VAL445 |
| B | ASN446 |
| B | ARG447 |
| B | PRO474 |
| site_id | AC5 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE JLN A 1528 |
| Chain | Residue |
| A | SER16 |
| A | VAL17 |
| A | TYR18 |
| A | LYS20 |
| A | THR40 |
| A | GLY41 |
| A | SER42 |
| A | THR43 |
| A | ARG70 |
| A | VAL71 |
| A | LYS72 |
| A | THR73 |
| A | LEU74 |
| A | ASN109 |
| A | TYR111 |
| A | ASP131 |
| A | ILE132 |
| A | GLY133 |
| A | GLY134 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K B 1524 |
| Chain | Residue |
| B | CYS421 |
| B | ARG422 |
| B | VAL424 |
| B | ASP470 |
| B | HIS520 |
| B | ALA522 |
| site_id | AC7 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE AMZ B 1525 |
| Chain | Residue |
| A | ASN427 |
| A | ARG447 |
| A | ALA471 |
| A | PHE472 |
| A | ARG519 |
| A | PHE521 |
| A | PO41526 |
| A | HOH2137 |
| B | ARG224 |
| B | TYR225 |
| B | SER257 |
| B | ASN259 |
| B | LYS283 |
| B | HIS284 |
| B | GLY314 |
| B | GLU337 |
| B | HOH2044 |
| B | HOH2045 |
| B | HOH2057 |
| B | HOH2128 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 B 1526 |
| Chain | Residue |
| B | VAL17 |
| B | LYS20 |
| B | THR40 |
| B | GLY41 |
| B | SER42 |
| B | THR43 |
