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4A0K

STRUCTURE OF DDB1-DDB2-CUL4A-RBX1 BOUND TO A 12 BP ABASIC SITE CONTAINING DNA-DUPLEX

Functional Information from GO Data
ChainGOidnamespacecontents
A0000082biological_processG1/S transition of mitotic cell cycle
A0001701biological_processin utero embryonic development
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0006281biological_processDNA repair
A0006511biological_processubiquitin-dependent protein catabolic process
A0006974biological_processDNA damage response
A0007283biological_processspermatogenesis
A0008283biological_processcell population proliferation
A0008284biological_processpositive regulation of cell population proliferation
A0016567biological_processprotein ubiquitination
A0030097biological_processhemopoiesis
A0030853biological_processnegative regulation of granulocyte differentiation
A0031461cellular_componentcullin-RING ubiquitin ligase complex
A0031464cellular_componentCul4A-RING E3 ubiquitin ligase complex
A0031625molecular_functionubiquitin protein ligase binding
A0034644biological_processcellular response to UV
A0035019biological_processsomatic stem cell population maintenance
A0042110biological_processT cell activation
A0042254biological_processribosome biogenesis
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0045732biological_processpositive regulation of protein catabolic process
A0048511biological_processrhythmic process
A0051246biological_processregulation of protein metabolic process
A0061630molecular_functionubiquitin protein ligase activity
A0080008cellular_componentCul4-RING E3 ubiquitin ligase complex
A0097193biological_processintrinsic apoptotic signaling pathway
A0140627biological_processubiquitin-dependent protein catabolic process via the C-end degron rule pathway
A0160072molecular_functionubiquitin ligase complex scaffold activity
A1900087biological_processpositive regulation of G1/S transition of mitotic cell cycle
A2000001biological_processregulation of DNA damage checkpoint
A2000819biological_processregulation of nucleotide-excision repair
B0000151cellular_componentubiquitin ligase complex
B0000209biological_processprotein polyubiquitination
B0004842molecular_functionubiquitin-protein transferase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005680cellular_componentanaphase-promoting complex
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006281biological_processDNA repair
B0006511biological_processubiquitin-dependent protein catabolic process
B0006513biological_processprotein monoubiquitination
B0006974biological_processDNA damage response
B0007283biological_processspermatogenesis
B0008190molecular_functioneukaryotic initiation factor 4E binding
B0008270molecular_functionzinc ion binding
B0016567biological_processprotein ubiquitination
B0016740molecular_functiontransferase activity
B0019005cellular_componentSCF ubiquitin ligase complex
B0030163biological_processprotein catabolic process
B0030891cellular_componentVCB complex
B0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
B0031461cellular_componentcullin-RING ubiquitin ligase complex
B0031462cellular_componentCul2-RING ubiquitin ligase complex
B0031463cellular_componentCul3-RING ubiquitin ligase complex
B0031464cellular_componentCul4A-RING E3 ubiquitin ligase complex
B0031465cellular_componentCul4B-RING E3 ubiquitin ligase complex
B0031466cellular_componentCul5-RING ubiquitin ligase complex
B0031467cellular_componentCul7-RING ubiquitin ligase complex
B0031625molecular_functionubiquitin protein ligase binding
B0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
B0032480biological_processnegative regulation of type I interferon production
B0034450molecular_functionubiquitin-ubiquitin ligase activity
B0034644biological_processcellular response to UV
B0042110biological_processT cell activation
B0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0044877molecular_functionprotein-containing complex binding
B0045116biological_processprotein neddylation
B0045732biological_processpositive regulation of protein catabolic process
B0046872molecular_functionmetal ion binding
B0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
B0061630molecular_functionubiquitin protein ligase activity
B0061663molecular_functionNEDD8 ligase activity
B0070936biological_processprotein K48-linked ubiquitination
B0071230biological_processcellular response to amino acid stimulus
B0097602molecular_functioncullin family protein binding
B0140627biological_processubiquitin-dependent protein catabolic process via the C-end degron rule pathway
B1902499biological_processpositive regulation of protein autoubiquitination
B1902883biological_processnegative regulation of response to oxidative stress
B1904263biological_processpositive regulation of TORC1 signaling
C0000781cellular_componentchromosome, telomeric region
C0003676molecular_functionnucleic acid binding
C0003677molecular_functionDNA binding
C0003684molecular_functiondamaged DNA binding
C0005515molecular_functionprotein binding
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005730cellular_componentnucleolus
C0005737cellular_componentcytoplasm
C0006281biological_processDNA repair
C0006289biological_processnucleotide-excision repair
C0006511biological_processubiquitin-dependent protein catabolic process
C0006915biological_processapoptotic process
C0006974biological_processDNA damage response
C0007056biological_processspindle assembly involved in female meiosis
C0010498biological_processproteasomal protein catabolic process
C0016055biological_processWnt signaling pathway
C0016567biological_processprotein ubiquitination
C0019076biological_processviral release from host cell
C0030674molecular_functionprotein-macromolecule adaptor activity
C0031464cellular_componentCul4A-RING E3 ubiquitin ligase complex
C0031465cellular_componentCul4B-RING E3 ubiquitin ligase complex
C0032991cellular_componentprotein-containing complex
C0034644biological_processcellular response to UV
C0035234biological_processectopic germ cell programmed cell death
C0035861cellular_componentsite of double-strand break
C0042752biological_processregulation of circadian rhythm
C0043066biological_processnegative regulation of apoptotic process
C0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
C0044725biological_processepigenetic programming in the zygotic pronuclei
C0044877molecular_functionprotein-containing complex binding
C0045070biological_processpositive regulation of viral genome replication
C0045722biological_processpositive regulation of gluconeogenesis
C0045732biological_processpositive regulation of protein catabolic process
C0046726biological_processpositive regulation by virus of viral protein levels in host cell
C0048511biological_processrhythmic process
C0051093biological_processnegative regulation of developmental process
C0051702biological_processbiological process involved in interaction with symbiont
C0070062cellular_componentextracellular exosome
C0070914biological_processUV-damage excision repair
C0071987molecular_functionWD40-repeat domain binding
C0080008cellular_componentCul4-RING E3 ubiquitin ligase complex
C0097602molecular_functioncullin family protein binding
C0160072molecular_functionubiquitin ligase complex scaffold activity
C1901990biological_processregulation of mitotic cell cycle phase transition
C2000242biological_processnegative regulation of reproductive process
D0003684molecular_functiondamaged DNA binding
D0005634cellular_componentnucleus
D0006281biological_processDNA repair
D0080008cellular_componentCul4-RING E3 ubiquitin ligase complex
Functional Information from PROSITE/UniProt
site_idPS01256
Number of Residues28
DetailsCULLIN_1 Cullin family signature. LKkrIesLIDRdYMeRdkdnpnqYhYvA
ChainResidueDetails
ALEU732-ALA759

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. MATSsvDaTVKLWDL
ChainResidueDetails
DMET294-LEU308

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylserine => ECO:0007744|PubMed:19413330
ChainResidueDetails
CSER2

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
BCYS53
BCYS56
BCYS68
BCYS75
BHIS77
BHIS80
BHIS82
BCYS94
BASP97
CLYS1067
BCYS45

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q9ESW0
ChainResidueDetails
CTHR1125

site_idSWS_FT_FI4
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
CLYS1121

221051

PDB entries from 2024-06-12

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