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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

4A0B

Structure of hsDDB1-drDDB2 bound to a 16 bp CPD-duplex (pyrimidine at D-1 position) at 3.8 A resolution (CPD 4)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000781cellular_componentchromosome, telomeric region
A0003676molecular_functionnucleic acid binding
A0003677molecular_functionDNA binding
A0003684molecular_functiondamaged DNA binding
A0005515molecular_functionprotein binding
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0006281biological_processDNA repair
A0006289biological_processnucleotide-excision repair
A0006511biological_processubiquitin-dependent protein catabolic process
A0006915biological_processapoptotic process
A0006974biological_processDNA damage response
A0007056biological_processspindle assembly involved in female meiosis
A0010498biological_processproteasomal protein catabolic process
A0016055biological_processWnt signaling pathway
A0016567biological_processprotein ubiquitination
A0019076biological_processviral release from host cell
A0030674molecular_functionprotein-macromolecule adaptor activity
A0031464cellular_componentCul4A-RING E3 ubiquitin ligase complex
A0031465cellular_componentCul4B-RING E3 ubiquitin ligase complex
A0032991cellular_componentprotein-containing complex
A0034644biological_processcellular response to UV
A0035234biological_processectopic germ cell programmed cell death
A0035861cellular_componentsite of double-strand break
A0042752biological_processregulation of circadian rhythm
A0043066biological_processnegative regulation of apoptotic process
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0044725biological_processepigenetic programming in the zygotic pronuclei
A0044877molecular_functionprotein-containing complex binding
A0045070biological_processpositive regulation of viral genome replication
A0045722biological_processpositive regulation of gluconeogenesis
A0045732biological_processpositive regulation of protein catabolic process
A0046726biological_processpositive regulation by virus of viral protein levels in host cell
A0048511biological_processrhythmic process
A0051093biological_processnegative regulation of developmental process
A0051702biological_processbiological process involved in interaction with symbiont
A0070062cellular_componentextracellular exosome
A0070914biological_processUV-damage excision repair
A0071987molecular_functionWD40-repeat domain binding
A0080008cellular_componentCul4-RING E3 ubiquitin ligase complex
A0097225cellular_componentsperm midpiece
A0097228cellular_componentsperm principal piece
A0097229cellular_componentsperm end piece
A0097602molecular_functioncullin family protein binding
A0160072molecular_functionubiquitin ligase complex scaffold activity
A1901990biological_processregulation of mitotic cell cycle phase transition
A2000242biological_processnegative regulation of reproductive process
B0003684molecular_functiondamaged DNA binding
B0005634cellular_componentnucleus
B0006281biological_processDNA repair
B0080008cellular_componentCul4-RING E3 ubiquitin ligase complex
C0000781cellular_componentchromosome, telomeric region
C0003676molecular_functionnucleic acid binding
C0003677molecular_functionDNA binding
C0003684molecular_functiondamaged DNA binding
C0005515molecular_functionprotein binding
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005730cellular_componentnucleolus
C0005737cellular_componentcytoplasm
C0006281biological_processDNA repair
C0006289biological_processnucleotide-excision repair
C0006511biological_processubiquitin-dependent protein catabolic process
C0006915biological_processapoptotic process
C0006974biological_processDNA damage response
C0007056biological_processspindle assembly involved in female meiosis
C0010498biological_processproteasomal protein catabolic process
C0016055biological_processWnt signaling pathway
C0016567biological_processprotein ubiquitination
C0019076biological_processviral release from host cell
C0030674molecular_functionprotein-macromolecule adaptor activity
C0031464cellular_componentCul4A-RING E3 ubiquitin ligase complex
C0031465cellular_componentCul4B-RING E3 ubiquitin ligase complex
C0032991cellular_componentprotein-containing complex
C0034644biological_processcellular response to UV
C0035234biological_processectopic germ cell programmed cell death
C0035861cellular_componentsite of double-strand break
C0042752biological_processregulation of circadian rhythm
C0043066biological_processnegative regulation of apoptotic process
C0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
C0044725biological_processepigenetic programming in the zygotic pronuclei
C0044877molecular_functionprotein-containing complex binding
C0045070biological_processpositive regulation of viral genome replication
C0045722biological_processpositive regulation of gluconeogenesis
C0045732biological_processpositive regulation of protein catabolic process
C0046726biological_processpositive regulation by virus of viral protein levels in host cell
C0048511biological_processrhythmic process
C0051093biological_processnegative regulation of developmental process
C0051702biological_processbiological process involved in interaction with symbiont
C0070062cellular_componentextracellular exosome
C0070914biological_processUV-damage excision repair
C0071987molecular_functionWD40-repeat domain binding
C0080008cellular_componentCul4-RING E3 ubiquitin ligase complex
C0097225cellular_componentsperm midpiece
C0097228cellular_componentsperm principal piece
C0097229cellular_componentsperm end piece
C0097602molecular_functioncullin family protein binding
C0160072molecular_functionubiquitin ligase complex scaffold activity
C1901990biological_processregulation of mitotic cell cycle phase transition
C2000242biological_processnegative regulation of reproductive process
D0003684molecular_functiondamaged DNA binding
D0005634cellular_componentnucleus
D0006281biological_processDNA repair
D0080008cellular_componentCul4-RING E3 ubiquitin ligase complex
Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. MATSsvDaTVKLWDL
ChainResidueDetails
BMET294-LEU308
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues1
DetailsModified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q9ESW0","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues70
DetailsRepeat: {"description":"WD 1"}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues70
DetailsRepeat: {"description":"WD 2"}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues70
DetailsRepeat: {"description":"WD 3"}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues86
DetailsRepeat: {"description":"WD 4"}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues80
DetailsRepeat: {"description":"WD 5"}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues80
DetailsRepeat: {"description":"WD 6"}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues48
DetailsRepeat: {"description":"WD 7"}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues4
DetailsRegion: {"description":"Photolesion recognition","evidences":[{"source":"PubMed","id":"19109893","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues36
DetailsMotif: {"description":"DWD box","evidences":[{"source":"UniProtKB","id":"Q92466","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

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PDB entries from 2025-09-24

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