3ZJY
Crystal Structure of Importin 13 - RanGTP - eIF1A complex
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003924 | molecular_function | GTPase activity |
A | 0005525 | molecular_function | GTP binding |
A | 0006913 | biological_process | nucleocytoplasmic transport |
B | 0005515 | molecular_function | protein binding |
B | 0005634 | cellular_component | nucleus |
B | 0005737 | cellular_component | cytoplasm |
B | 0006606 | biological_process | protein import into nucleus |
B | 0006886 | biological_process | intracellular protein transport |
B | 0015031 | biological_process | protein transport |
B | 0031267 | molecular_function | small GTPase binding |
C | 0003723 | molecular_function | RNA binding |
C | 0003743 | molecular_function | translation initiation factor activity |
C | 0006413 | biological_process | translational initiation |
D | 0003924 | molecular_function | GTPase activity |
D | 0005525 | molecular_function | GTP binding |
D | 0006913 | biological_process | nucleocytoplasmic transport |
E | 0005515 | molecular_function | protein binding |
E | 0005634 | cellular_component | nucleus |
E | 0005737 | cellular_component | cytoplasm |
E | 0006606 | biological_process | protein import into nucleus |
E | 0006886 | biological_process | intracellular protein transport |
E | 0015031 | biological_process | protein transport |
E | 0031267 | molecular_function | small GTPase binding |
F | 0003924 | molecular_function | GTPase activity |
F | 0005525 | molecular_function | GTP binding |
F | 0006913 | biological_process | nucleocytoplasmic transport |
G | 0005515 | molecular_function | protein binding |
G | 0005634 | cellular_component | nucleus |
G | 0005737 | cellular_component | cytoplasm |
G | 0006606 | biological_process | protein import into nucleus |
G | 0006886 | biological_process | intracellular protein transport |
G | 0015031 | biological_process | protein transport |
G | 0031267 | molecular_function | small GTPase binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MG A 1178 |
Chain | Residue |
A | THR24 |
A | THR42 |
A | ASP65 |
A | GTP250 |
site_id | AC2 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE GTP A 250 |
Chain | Residue |
A | THR25 |
A | LYS37 |
A | TYR39 |
A | ALA41 |
A | THR42 |
A | THR66 |
A | GLY68 |
A | ASN122 |
A | ASP125 |
A | SER150 |
A | ALA151 |
A | LYS152 |
A | MG1178 |
A | GLY19 |
A | GLY20 |
A | GLY22 |
A | LYS23 |
A | THR24 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MG D 1178 |
Chain | Residue |
D | THR24 |
D | THR42 |
D | ASP65 |
D | GTP250 |
site_id | AC4 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE GTP D 250 |
Chain | Residue |
D | GLY19 |
D | GLY20 |
D | GLY22 |
D | LYS23 |
D | THR24 |
D | THR25 |
D | GLU36 |
D | LYS37 |
D | TYR39 |
D | VAL40 |
D | THR42 |
D | THR66 |
D | GLY68 |
D | LYS123 |
D | SER150 |
D | ALA151 |
D | LYS152 |
D | MG1178 |
site_id | AC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MG F 1178 |
Chain | Residue |
F | THR24 |
F | THR42 |
F | ASP65 |
F | GTP250 |
site_id | AC6 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE GTP F 250 |
Chain | Residue |
F | GLY19 |
F | GLY20 |
F | GLY22 |
F | LYS23 |
F | THR24 |
F | THR25 |
F | GLU36 |
F | LYS37 |
F | TYR39 |
F | VAL40 |
F | THR42 |
F | GLY68 |
F | ASN122 |
F | LYS123 |
F | ASP125 |
F | SER150 |
F | ALA151 |
F | MG1178 |
Functional Information from PROSITE/UniProt
site_id | PS01262 |
Number of Residues | 23 |
Details | IF1A Eukaryotic initiation factor 1A signature. MlGnGRleamCfDGvkRlcHIrG |
Chain | Residue | Details |
C | MET41-GLY63 |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | ASP18 | |
D | ASP18 | |
F | ASP18 |
Chain | Residue | Details |
A | GLU36 | |
D | GLU36 | |
F | GLU36 |
Chain | Residue | Details |
A | GLY68 | |
D | GLY68 | |
F | GLY68 |
Chain | Residue | Details |
A | ASN122 | |
D | ASN122 | |
F | ASN122 |
Chain | Residue | Details |
A | SER150 | |
D | SER150 | |
F | SER150 |
site_id | SWS_FT_FI6 |
Number of Residues | 3 |
Details | SITE: Essential for GTP hydrolysis => ECO:0000269|PubMed:18591255, ECO:0000269|PubMed:26272610, ECO:0000269|PubMed:8636225 |
Chain | Residue | Details |
A | LEU69 | |
D | LEU69 | |
F | LEU69 |
site_id | SWS_FT_FI7 |
Number of Residues | 3 |
Details | MOD_RES: N-acetylalanine => ECO:0000269|Ref.12, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378 |
Chain | Residue | Details |
A | ALA2 | |
D | ALA2 | |
F | ALA2 |
site_id | SWS_FT_FI8 |
Number of Residues | 3 |
Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | THR24 | |
D | THR24 | |
F | THR24 |
site_id | SWS_FT_FI9 |
Number of Residues | 3 |
Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:31075303 |
Chain | Residue | Details |
A | LYS37 | |
D | LYS37 | |
F | LYS37 |
site_id | SWS_FT_FI10 |
Number of Residues | 6 |
Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
Chain | Residue | Details |
A | LYS60 | |
A | LYS99 | |
D | LYS60 | |
D | LYS99 | |
F | LYS60 | |
F | LYS99 |
site_id | SWS_FT_FI11 |
Number of Residues | 3 |
Details | MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861 |
Chain | Residue | Details |
A | LYS71 | |
D | LYS71 | |
F | LYS71 |
site_id | SWS_FT_FI12 |
Number of Residues | 3 |
Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:29040603 |
Chain | Residue | Details |
A | LYS134 | |
D | LYS134 | |
F | LYS134 |
site_id | SWS_FT_FI13 |
Number of Residues | 3 |
Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P62827 |
Chain | Residue | Details |
A | LYS159 | |
D | LYS159 | |
F | LYS159 |
site_id | SWS_FT_FI14 |
Number of Residues | 3 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate |
Chain | Residue | Details |
A | LYS71 | |
D | LYS71 | |
F | LYS71 |
site_id | SWS_FT_FI15 |
Number of Residues | 6 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
A | LYS152 | |
D | LYS152 | |
F | LYS152 |