3ZHR
Crystal structure of the H747A mutant of the SucA domain of Mycobacterium smegmatis KGD showing the active site lid closed
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016624 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor |
| A | 0030976 | molecular_function | thiamine pyrophosphate binding |
| B | 0016624 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor |
| B | 0030976 | molecular_function | thiamine pyrophosphate binding |
| C | 0016624 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor |
| C | 0030976 | molecular_function | thiamine pyrophosphate binding |
| D | 0016624 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor |
| D | 0030976 | molecular_function | thiamine pyrophosphate binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE TPP A 2001 |
| Chain | Residue |
| A | ARG540 |
| A | ILE680 |
| A | GLY681 |
| A | MG2002 |
| A | HOH3047 |
| A | HOH3081 |
| A | HOH3082 |
| A | HOH3107 |
| A | HOH3338 |
| A | HOH3339 |
| B | GLN901 |
| A | SER604 |
| B | LEU950 |
| B | GLU952 |
| B | GLN976 |
| B | PHE980 |
| A | HIS605 |
| A | LEU606 |
| A | GLY644 |
| A | ASP645 |
| A | ALA646 |
| A | ALA647 |
| A | ASN678 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 2002 |
| Chain | Residue |
| A | ASP645 |
| A | ASN678 |
| A | ILE680 |
| A | TPP2001 |
| A | HOH3082 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 2003 |
| Chain | Residue |
| A | ASP1004 |
| A | HIS1055 |
| A | ASP1058 |
| A | ILE1060 |
| A | HOH3238 |
| A | HOH3239 |
| site_id | AC4 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE TPP B 2001 |
| Chain | Residue |
| A | GLN901 |
| A | LEU950 |
| A | GLU952 |
| A | GLN976 |
| A | PHE980 |
| B | ARG540 |
| B | SER604 |
| B | HIS605 |
| B | LEU606 |
| B | GLY644 |
| B | ASP645 |
| B | ALA646 |
| B | ALA647 |
| B | ASN678 |
| B | ILE680 |
| B | GLY681 |
| B | MG2002 |
| B | HOH3044 |
| B | HOH3045 |
| B | HOH3078 |
| B | HOH3079 |
| B | HOH3258 |
| B | HOH3259 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 2002 |
| Chain | Residue |
| B | ASP645 |
| B | ASN678 |
| B | ILE680 |
| B | TPP2001 |
| B | HOH3079 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 2003 |
| Chain | Residue |
| B | ASP1004 |
| B | HIS1055 |
| B | ASP1058 |
| B | ILE1060 |
| B | HOH3184 |
| B | HOH3185 |
| site_id | AC7 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE TPP C 2001 |
| Chain | Residue |
| C | ARG540 |
| C | SER604 |
| C | HIS605 |
| C | LEU606 |
| C | GLY644 |
| C | ASP645 |
| C | ALA646 |
| C | ALA647 |
| C | ASN678 |
| C | ILE680 |
| C | GLY681 |
| C | MG2002 |
| C | HOH3048 |
| C | HOH3081 |
| C | HOH3082 |
| C | HOH3107 |
| C | HOH3325 |
| C | HOH3326 |
| D | GLN901 |
| D | LEU950 |
| D | GLU952 |
| D | GLN976 |
| D | PHE980 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG C 2002 |
| Chain | Residue |
| C | ASP645 |
| C | ASN678 |
| C | ILE680 |
| C | TPP2001 |
| C | HOH3082 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA C 2003 |
| Chain | Residue |
| C | ILE1060 |
| C | HOH3240 |
| C | HOH3241 |
| C | ASP1004 |
| C | HIS1055 |
| C | ASP1058 |
| site_id | BC1 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE TPP D 2001 |
| Chain | Residue |
| C | GLN901 |
| C | LEU950 |
| C | GLU952 |
| C | GLN976 |
| C | PHE980 |
| D | ARG540 |
| D | SER604 |
| D | HIS605 |
| D | LEU606 |
| D | GLY644 |
| D | ASP645 |
| D | ALA646 |
| D | ALA647 |
| D | ASN678 |
| D | ILE680 |
| D | GLY681 |
| D | MG2002 |
| D | HOH3038 |
| D | HOH3067 |
| D | HOH3068 |
| D | HOH3091 |
| D | HOH3250 |
| D | HOH3251 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG D 2002 |
| Chain | Residue |
| D | ASP645 |
| D | ASN678 |
| D | ILE680 |
| D | TPP2001 |
| D | HOH3068 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA D 2003 |
| Chain | Residue |
| D | ASP1004 |
| D | HIS1055 |
| D | ASP1058 |
| D | ILE1060 |
| D | HOH3183 |
| D | HOH3184 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MPD A 2228 |
| Chain | Residue |
| A | ARG1054 |
| A | ASP1058 |
| A | GLN1142 |
| A | HOH3271 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MPD B 2228 |
| Chain | Residue |
| B | THR1038 |
| B | ARG1054 |
| B | ASP1058 |
| B | HOH3205 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MPD C 2228 |
| Chain | Residue |
| C | ARG1054 |
| C | ASP1058 |
| C | GLN1142 |
| C | HOH3266 |
| site_id | BC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MPD D 2228 |
| Chain | Residue |
| D | THR1038 |
| D | ARG1054 |
| D | ASP1058 |
| D | GLN1142 |
| D | HOH3202 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 60 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21867916, ECO:0007744|PDB:2XTA |
| Chain | Residue | Details |
| A | ARG540 | |
| A | ARG1054 | |
| A | LYS1089 | |
| A | SER1092 | |
| A | GLN1142 | |
| A | ARG1149 | |
| A | ARG1150 | |
| B | ARG540 | |
| B | SER604 | |
| B | LEU606 | |
| B | ASP645 | |
| A | SER604 | |
| B | ALA646 | |
| B | ALA647 | |
| B | ASN678 | |
| B | ILE680 | |
| B | THR1038 | |
| B | ARG1054 | |
| B | LYS1089 | |
| B | SER1092 | |
| B | GLN1142 | |
| B | ARG1149 | |
| A | LEU606 | |
| B | ARG1150 | |
| C | ARG540 | |
| C | SER604 | |
| C | LEU606 | |
| C | ASP645 | |
| C | ALA646 | |
| C | ALA647 | |
| C | ASN678 | |
| C | ILE680 | |
| C | THR1038 | |
| A | ASP645 | |
| C | ARG1054 | |
| C | LYS1089 | |
| C | SER1092 | |
| C | GLN1142 | |
| C | ARG1149 | |
| C | ARG1150 | |
| D | ARG540 | |
| D | SER604 | |
| D | LEU606 | |
| D | ASP645 | |
| A | ALA646 | |
| D | ALA646 | |
| D | ALA647 | |
| D | ASN678 | |
| D | ILE680 | |
| D | THR1038 | |
| D | ARG1054 | |
| D | LYS1089 | |
| D | SER1092 | |
| D | GLN1142 | |
| D | ARG1149 | |
| A | ALA647 | |
| D | ARG1150 | |
| A | ASN678 | |
| A | ILE680 | |
| A | THR1038 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:21867916, ECO:0007744|PDB:2Y0P |
| Chain | Residue | Details |
| A | HIS579 | |
| A | HIS1020 | |
| B | HIS579 | |
| B | HIS1020 | |
| C | HIS579 | |
| C | HIS1020 | |
| D | HIS579 | |
| D | HIS1020 |
