3ZGZ
Ternary complex of E. coli leucyl-tRNA synthetase, tRNA(leu) and toxic moiety from agrocin 84 (TM84) in aminoacylation-like conformation
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0002161 | molecular_function | aminoacyl-tRNA deacylase activity |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004823 | molecular_function | leucine-tRNA ligase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006412 | biological_process | translation |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006429 | biological_process | leucyl-tRNA aminoacylation |
| A | 0016874 | molecular_function | ligase activity |
| A | 0106074 | biological_process | aminoacyl-tRNA metabolism involved in translational fidelity |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0002161 | molecular_function | aminoacyl-tRNA deacylase activity |
| D | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| D | 0004823 | molecular_function | leucine-tRNA ligase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006412 | biological_process | translation |
| D | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| D | 0006429 | biological_process | leucyl-tRNA aminoacylation |
| D | 0016874 | molecular_function | ligase activity |
| D | 0106074 | biological_process | aminoacyl-tRNA metabolism involved in translational fidelity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 1077 |
| Chain | Residue |
| B | U20 |
| B | HOH2058 |
| B | HOH2059 |
| B | HOH2060 |
| B | HOH2061 |
| B | HOH2062 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 1078 |
| Chain | Residue |
| B | HOH2065 |
| B | HOH2066 |
| B | G45 |
| B | HOH2063 |
| B | HOH2064 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 1079 |
| Chain | Residue |
| B | U8 |
| B | G9 |
| B | HOH2067 |
| B | HOH2068 |
| B | HOH2069 |
| B | HOH2070 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG B 1080 |
| Chain | Residue |
| B | U8 |
| B | G13 |
| B | HOH2071 |
| B | HOH2072 |
| B | HOH2073 |
| B | HOH2074 |
| B | HOH2075 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG B 1081 |
| Chain | Residue |
| B | U48 |
| B | C50 |
| B | HOH2039 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG E 1077 |
| Chain | Residue |
| E | U8 |
| E | G9 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG E 1078 |
| Chain | Residue |
| E | U8 |
| E | G13 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1861 |
| Chain | Residue |
| A | CYS159 |
| A | ASP162 |
| A | CYS176 |
| A | CYS179 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN D 1861 |
| Chain | Residue |
| D | CYS159 |
| D | ASP162 |
| D | CYS176 |
| D | CYS179 |
| D | THR181 |
| site_id | BC1 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE 84T A 1862 |
| Chain | Residue |
| A | MET40 |
| A | LEU41 |
| A | PRO42 |
| A | TYR43 |
| A | HIS49 |
| A | GLY51 |
| A | HIS52 |
| A | ASN55 |
| A | TYR56 |
| A | ASP80 |
| A | SER496 |
| A | GLY530 |
| A | GLU532 |
| A | HIS533 |
| A | GLN566 |
| A | MET568 |
| A | VAL569 |
| A | MET620 |
| A | LYS622 |
| A | HOH2024 |
| A | HOH2175 |
| B | A76 |
| site_id | BC2 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE 84T D 1862 |
| Chain | Residue |
| D | MET40 |
| D | LEU41 |
| D | PRO42 |
| D | TYR43 |
| D | HIS49 |
| D | GLY51 |
| D | HIS52 |
| D | TYR56 |
| D | ASP80 |
| D | SER496 |
| D | GLY530 |
| D | GLU532 |
| D | HIS533 |
| D | HIS537 |
| D | GLN566 |
| D | GLY567 |
| D | MET568 |
| D | VAL569 |
| D | MET620 |
| D | LYS622 |
| D | HOH2006 |
| E | A76 |
Functional Information from PROSITE/UniProt
| site_id | PS00178 |
| Number of Residues | 12 |
| Details | AA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. PypSGrLHMGHV |
| Chain | Residue | Details |
| A | PRO42-VAL53 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | Motif: {"description":"'HIGH' region"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Motif: {"description":"'KMSKS' region"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00049","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
