3ZE3

Crystal structure of the integral membrane diacylglycerol kinase - delta7

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Functional Information from GO Data

ChainGOidnamespacecontents
A0016021cellular_componentintegral component of membrane
A0016020cellular_componentmembrane
A0005886cellular_componentplasma membrane
A0005524molecular_functionATP binding
A0004143molecular_functiondiacylglycerol kinase activity
A0006654biological_processphosphatidic acid biosynthetic process
A0009411biological_processresponse to UV
B0016021cellular_componentintegral component of membrane
B0016020cellular_componentmembrane
B0005886cellular_componentplasma membrane
B0005524molecular_functionATP binding
B0004143molecular_functiondiacylglycerol kinase activity
B0006654biological_processphosphatidic acid biosynthetic process
B0009411biological_processresponse to UV
C0016021cellular_componentintegral component of membrane
C0016020cellular_componentmembrane
C0005886cellular_componentplasma membrane
C0005524molecular_functionATP binding
C0004143molecular_functiondiacylglycerol kinase activity
C0006654biological_processphosphatidic acid biosynthetic process
C0009411biological_processresponse to UV
D0016021cellular_componentintegral component of membrane
D0016020cellular_componentmembrane
D0005886cellular_componentplasma membrane
D0005524molecular_functionATP binding
D0004143molecular_functiondiacylglycerol kinase activity
D0006654biological_processphosphatidic acid biosynthetic process
D0009411biological_processresponse to UV
E0016021cellular_componentintegral component of membrane
E0016020cellular_componentmembrane
E0005886cellular_componentplasma membrane
E0005524molecular_functionATP binding
E0004143molecular_functiondiacylglycerol kinase activity
E0006654biological_processphosphatidic acid biosynthetic process
E0009411biological_processresponse to UV
F0016021cellular_componentintegral component of membrane
F0016020cellular_componentmembrane
F0005886cellular_componentplasma membrane
F0005524molecular_functionATP binding
F0004143molecular_functiondiacylglycerol kinase activity
F0006654biological_processphosphatidic acid biosynthetic process
F0009411biological_processresponse to UV
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Functional Information from PDB Data

site_idNumber of ResiduesDetails
AC16BINDING SITE FOR RESIDUE NA F 1122
ChainResidue
DLEU64
DASP107
DHOH2044
FSER60
FLEU64
FHOH2024

AC24BINDING SITE FOR RESIDUE NA E 1122
ChainResidue
DSER60
ESER61
ETHR111
EHOH2020

AC34BINDING SITE FOR RESIDUE ZN D 1122
ChainResidue
DGLU28
DGLU76
DFLC1123
DACT1124

AC44BINDING SITE FOR RESIDUE FLC D 1123
ChainResidue
DGLU76
DZN1122
DACT1124
DHOH2048

AC58BINDING SITE FOR RESIDUE ACT D 1124
ChainResidue
DGLU28
DGLU69
DASN72
DSER73
DGLU76
DZN1122
DFLC1123
DHOH2047

AC611BINDING SITE FOR RESIDUE 78N B 1122
ChainResidue
AALA13
AALA14
ASER17
A78N1123
A78N1124
BSER98
BVAL101
BLEU102
BILE105
BILE110
B78N1123

AC79BINDING SITE FOR RESIDUE 78N B 1123
ChainResidue
AARG9
A78N1124
BGLU34
BVAL65
BGLU69
BALA108
BTRP112
BALA113
B78N1122

AC812BINDING SITE FOR RESIDUE 78M D 1125
ChainResidue
AGLN33
AGLU34
A78M1126
CTRP117
C78N1122
DTRP25
DALA29
DARG32
DGLN33
DVAL36
DHOH2017
DHOH2049

AC910BINDING SITE FOR RESIDUE 78N C 1122
ChainResidue
A78M1126
BALA46
BARG55
BHOH2010
CILE110
CILE114
CTRP117
CSER118
DGLN33
D78M1125

BC17BINDING SITE FOR RESIDUE 78N A 1122
ChainResidue
ATRP18
AARG22
ATRP25
AILE26
ALEU39
AMET63
AMET66

BC210BINDING SITE FOR RESIDUE 78M D 1126
ChainResidue
AALA30
APHE31
AGLU34
AGLU69
ALEU102
AILE105
AHOH2012
DARG22
DTRP25
DHOH2050

BC38BINDING SITE FOR RESIDUE 78M D 1127
ChainResidue
BTRP47
BHOH2006
BHOH2008
DLEU102
DVAL109
DALA113
DHOH2018
DHOH2043

BC46BINDING SITE FOR RESIDUE 78N C 1123
ChainResidue
ALEU40
ATRP47
A78M1126
CGLU34
CGLU69
CTRP112

BC57BINDING SITE FOR RESIDUE 78M D 1128
ChainResidue
ATRP117
BGLY35
BVAL36
DTRP47
DLEU48
DASP49
DPHE120

BC66BINDING SITE FOR RESIDUE 78N A 1123
ChainResidue
AVAL42
AALA46
AARG55
A78N1124
AHOH2016
B78N1122

BC79BINDING SITE FOR RESIDUE 78N A 1124
ChainResidue
AVAL50
AASP51
AALA52
AARG55
A78N1123
BILE114
BTRP117
B78N1122
B78N1123

BC85BINDING SITE FOR RESIDUE 78M A 1125
ChainResidue
AILE110
ATRP117
DALA46
DTRP47
DARG55

BC99BINDING SITE FOR RESIDUE 78M A 1126
ChainResidue
ACYS41
APHE120
AHOH2015
CLEU102
CILE105
C78N1122
C78N1123
DLEU39
D78M1125

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Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
78N_3ze3_B_112316(2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE binding site
ChainResidueligand
AARG9-ILE1078N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
BGLU3478N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
BALA37-VAL3878N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
BCYS4178N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
BVAL6278N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
BVAL6578N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
BGLU6978N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
BVAL10178N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
BILE10578N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
BALA108-VAL10978N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
BTRP112-ALA11378N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
BLEU11678N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE

78N_3ze3_B_112214(2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE binding site
ChainResidueligand
AILE1078N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
AALA13-ALA1478N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
ASER1778N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
BGLU6978N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
BASN7278N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
BSER98-ALA9978N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
BVAL101-LEU10278N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
BILE105-ILE10678N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
BVAL109-ILE11078N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE

78N_3ze3_A_112215(2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE binding site
ChainResidueligand
ATRP1878N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
ALEU21-ARG2278N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
ATRP25-ILE2678N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
APHE3178N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
AGLY3578N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
AVAL38-LEU3978N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
AVAL4278N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
AMET6378N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
AMET6678N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
BILE10378N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
BILE10678N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
BILE11078N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE

78M_3ze3_A_11268(2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE binding site
ChainResidueligand
AALA3778M: (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
ALEU40-CYS4178M: (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
AILE4478M: (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
ALEU4878M: (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
ATRP11278M: (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
ALEU11678M: (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
APHE12078M: (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE

78N_3ze3_A_11238(2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE binding site
ChainResidueligand
ALEU3978N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
AVAL42-VAL4378N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
AALA4678N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
AARG5578N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
AILE5978N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
BILE11078N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
BILE11478N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE

78N_3ze3_A_11249(2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE binding site
ChainResidueligand
AVAL50-ALA5278N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
AARG5578N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
BVAL109-ILE11078N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
BALA113-ILE11478N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
BTRP11778N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE

78M_3ze3_A_11252(2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE binding site
ChainResidueligand
AILE11078M: (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
ATRP11778M: (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE

78M_3ze3_D_112818(2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE binding site
ChainResidueligand
BILE26-ASN2778M: (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
BARG3278M: (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
BGLY35-VAL3678M: (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
BVAL38-LEU3978M: (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
BVAL4278M: (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
BMET6378M: (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
BMET6678M: (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
CILE10378M: (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
CILE10678M: (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
CILE11078M: (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
DLEU4078M: (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
DTRP47-ASP4978M: (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
DPHE12078M: (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE

78M_3ze3_D_112718(2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE binding site
ChainResidueligand
BLEU4078M: (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
BILE4478M: (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
BTRP47-ASP4978M: (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
BHIS119-PHE12078M: (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
DGLN33-GLU3478M: (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
DSER9878M: (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
DVAL101-LEU10278M: (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
DILE105-ILE10678M: (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
DVAL109-ILE11078M: (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
DALA113-ILE11478M: (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE

78N_3ze3_C_112217(2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE binding site
ChainResidueligand
BALA4678N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
BVAL5078N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
BALA5278N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
BARG5578N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
BILE5978N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
CILE11078N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
CALA113-LEU11578N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
CTRP117-SER11878N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
DGLN3378N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
DVAL36-ALA3778N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
DLEU39-LEU4078N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
DVAL4378N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE

78N_3ze3_C_112313(2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE binding site
ChainResidueligand
CGLU3478N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
CALA3778N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
CCYS4178N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
CILE4478N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
CVAL6278N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
CVAL65-MET6678N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
CGLU6978N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
CILE10578N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
CALA108-VAL10978N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
CTRP11278N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
CLEU11678N: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE

78M_3ze3_D_11256(2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE binding site
ChainResidueligand
CTRP11778M: (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
DTRP2578M: (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
DALA2978M: (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
DARG32-GLN3378M: (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
DVAL3678M: (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE

78M_3ze3_D_112611(2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE binding site
ChainResidueligand
DLEU21-ARG2278M: (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
DTRP25-ILE2678M: (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
DPHE3178M: (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
DGLY3578M: (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
DVAL38-LEU3978M: (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
DMET6378M: (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
DMET6678M: (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
EILE10378M: (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE

FLC_3ze3_D_11233CITRATE ANION binding site
ChainResidueligand
DASN27-GLU28FLC: CITRATE ANION
DGLU76FLC: CITRATE ANION

ACT_3ze3_D_11246ACETATE ION binding site
ChainResidueligand
DGLU28ACT: ACETATE ION
DALA30ACT: ACETATE ION
DGLU69ACT: ACETATE ION
DASN72-SER73ACT: ACETATE ION
DGLU76ACT: ACETATE ION

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Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
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Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
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Catalytic Information from CSA

site_idNumber of ResiduesDetails