Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3X41

Copper amine oxidase from Arthrobacter globiformis: Product Schiff-base form produced by anaerobic reduction in the presence of sodium bromide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005507	molecular_function	copper ion binding
A	0008131	molecular_function	primary methylamine oxidase activity
A	0009308	biological_process	amine metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016641	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
A	0046872	molecular_function	metal ion binding
A	0048038	molecular_function	quinone binding
B	0005507	molecular_function	copper ion binding
B	0008131	molecular_function	primary methylamine oxidase activity
B	0009308	biological_process	amine metabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016641	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
B	0046872	molecular_function	metal ion binding
B	0048038	molecular_function	quinone binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CU A 701

Chain	Residue
A	HIS431
A	HIS433
A	HIS592
A	BR702
A	HOH1154

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE BR A 702

Chain	Residue
A	MET602
A	CU701
A	2TY382
A	HIS431
A	HIS433
A	HIS592

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE BR A 703

Chain	Residue
A	HIS345
A	SER374

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BR A 704

Chain	Residue
A	GLY34
A	PRO35
A	GLU36

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 705

Chain	Residue
A	ASP440
A	MET441
A	ASP581
A	ILE582
A	HOH845

site_id	AC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE K A 706

Chain	Residue
A	VAL79
A	THR80
A	ALA93
A	ALA94
A	ARG148
A	SER562
A	HOH1087
A	HOH1138
A	HOH1165

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 707

Chain	Residue
A	THR521
A	LEU522
A	LEU523
A	THR538
A	HOH872
B	ARG457
B	HOH1053

site_id	AC8
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A 708

Chain	Residue
A	GLU347
A	ARG370
A	LYS401
A	GOL711
A	HOH946
A	HOH1007
A	HOH1169
A	HOH1221
B	HOH1060
B	HOH1142

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 709

Chain	Residue
A	ASN368
A	TYR391
A	ASP393
A	GLU397
A	LYS610
A	HOH1171
A	HOH1229
B	HOH1059

site_id	BC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A 710

Chain	Residue
A	ILE39
A	TYR41
A	LEU42
A	VAL251
A	GLN306
A	SER329
A	ASP330
A	ALA331
A	HOH887
A	HOH896

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 711

Chain	Residue
A	ARG370
A	GLU397
A	GLU399
A	GOL708
A	HOH1332
B	GOL714

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 712

Chain	Residue
A	ASP605
A	HOH1187
A	HOH1191
B	HIS515
B	LYS610

site_id	BC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 713

Chain	Residue
A	GLU102
A	THR378
A	GLY380
A	HOH827
A	HOH1156
A	HOH1157
A	HOH1277
B	LEU358

site_id	BC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A 714

Chain	Residue
A	ALA15
A	LEU42
A	GLY43
A	VAL44
A	PHE249
A	ASP250
A	VAL251
A	VAL327
A	ILE328
A	HOH929

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CU B 701

Chain	Residue
B	HIS431
B	HIS433
B	HIS592
B	BR702
B	HOH1149

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE BR B 702

Chain	Residue
B	2TY382
B	HIS431
B	HIS433
B	MET602
B	CU701

site_id	BC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BR B 703

Chain	Residue
B	SER529
B	ARG532
B	SER562

site_id	BC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BR B 704

Chain	Residue
B	HIS345
B	SER374
B	HOH962

site_id	CC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE BR B 705

Chain	Residue
B	ASP128

site_id	CC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BR B 706

Chain	Residue
B	GLY34
B	PRO35
B	GLU36

site_id	CC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA B 707

Chain	Residue
B	ASP440
B	MET441
B	ASP581
B	ILE582
B	HOH815

site_id	CC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE K B 708

Chain	Residue
B	VAL79
B	THR80
B	ALA93
B	ALA94
B	SER562
B	HOH952
B	HOH1338

site_id	CC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL B 709

Chain	Residue
B	ARG532
B	ARG533
B	THR554
B	PHE557
B	HIS561
B	SER562
B	GLY563
B	GLY564
B	ALA565
B	HOH819

site_id	CC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL B 710

Chain	Residue
A	ARG457
B	THR521
B	LEU522
B	THR538
B	HOH893
B	HOH1192

site_id	CC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL B 711

Chain	Residue
B	GLU347
B	ARG370
B	LYS401
B	GOL714
B	HOH930
B	HOH1060
B	HOH1101

site_id	CC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL B 712

Chain	Residue
B	ASP161
B	VAL197
B	HOH1083
B	HOH1204

site_id	CC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL B 713

Chain	Residue
A	LYS610
B	LEU590
B	ASP605
B	THR606

site_id	DC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL B 714

Chain	Residue
A	GOL711
B	ARG370
B	TYR389
B	TYR391
B	GLU397
B	GLU399
B	GOL711

site_id	DC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL B 715

Chain	Residue
B	GLU102
B	PHE105
B	THR378
B	GLY380
B	HOH817
B	HOH1260
B	HOH1268

site_id	DC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL B 716

Chain	Residue
B	ILE39
B	TYR41
B	LEU42
B	VAL251
B	ILE328
B	SER329
B	ASP330
B	HOH915

site_id	DC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL B 717

Chain	Residue
B	LEU42
B	GLY43
B	VAL44
B	PHE249
B	ASP250
B	VAL251
B	VAL327
B	HOH1018
B	HOH1373

Functional Information from PROSITE/UniProt

site_id	PS01164
Number of Residues	14
Details	COPPER_AMINE_OXID_1 Copper amine oxidase topaquinone signature. MVIsfftTigNYDY

Chain	Residue	Details
A	MET371-TYR384

site_id	PS01165
Number of Residues	14
Details	COPPER_AMINE_OXID_2 Copper amine oxidase copper-binding site signature. TfGltHFprvEDwP

Chain	Residue	Details
A	THR587-PRO600

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"UniProtKB","id":"P12807","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Schiff-base intermediate with substrate; via topaquinone","evidences":[{"source":"UniProtKB","id":"P12807","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	22
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P12807","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"9405045","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1AV4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1AVL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1IU7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1IVU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1IVV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1IVW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1IVX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RJO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SIH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SII","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1UI8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1W4N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1W5Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1W6C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1W6G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BT3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CFD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CFG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CFK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CFL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CFW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CG0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CG1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CWT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CWU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CWV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2D1W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E2T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E2U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E2V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2YX9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZL8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AMO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KII","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KN4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WA2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WA3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"2',4',5'-topaquinone","evidences":[{"source":"PubMed","id":"9405045","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)