1SIH

AGAO in covalent complex with the inhibitor MOBA ("4-(4-methylphenoxy)-2-butyn-1-amine")

Summary for 1SIH

• Entry DOI: 10.2210/pdb1sih/pdb
• Related: 1AV4 1SII
• Descriptor: Phenylethylamine oxidase, SULFATE ION, COPPER (II) ION, ... (6 entities in total)
• Functional Keywords: cao, cuao, copper-containing, amine oxidase, tpq, quinone, trihydroxyphenylalanine quinone, moba, 4-(4-methylphenoxyoxy)-2-butyn-1-amine, 4-(aryloxy)-2-butynamine, suicide inhibition, oxidoreductase
• Biological source: Arthrobacter globiformis
• Total number of polymer chains: 1
• Total formula weight: 72305.79

Authors

Guss, J.M.,Langley, D.B.,Duff, A.P. (deposition date: 2004-02-29, release date: 2004-09-07, Last modification date: 2017-10-11)

• Primary citation: O'Connell, K.M.,Langley, D.B.,Shepard, E.M.,Duff, A.P.,Jeon, H.B.,Sun, G.,Freeman, H.C.,Guss, J.M.,Sayre, L.M.,Dooley, D.M.; Differential Inhibition of Six Copper Amine Oxidases by a Family of 4-(Aryloxy)-2-butynamines: Evidence for a New Mode of Inactivation.; Biochemistry, 43:10965-10978, 2004; PubMed: 15323556; DOI: 10.1021/bi0492004

Experimental method

X-RAY DIFFRACTION (1.73 Å)