3X40

Copper amine oxidase from Arthrobacter globiformis: Product Schiff-base form produced by anaerobic reduction in the presence of sodium chloride

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005507	molecular_function	copper ion binding
A	0008131	molecular_function	primary amine oxidase activity
A	0009308	biological_process	amine metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0046872	molecular_function	metal ion binding
A	0048038	molecular_function	quinone binding
A	0052595	molecular_function	aliphatic amine oxidase activity
B	0005507	molecular_function	copper ion binding
B	0008131	molecular_function	primary amine oxidase activity
B	0009308	biological_process	amine metabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0046872	molecular_function	metal ion binding
B	0048038	molecular_function	quinone binding
B	0052595	molecular_function	aliphatic amine oxidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CU A 701

Chain	Residue
A	HIS431
A	HIS433
A	HIS592
A	CL702
A	HOH1370

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CL A 702

Chain	Residue
A	MET602
A	CU701
A	HOH824
A	HOH1370
A	2TY382
A	HIS431
A	HIS433
A	HIS592

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL A 703

Chain	Residue
A	HIS345
A	SER374
A	TYR387
A	HOH1150
A	HOH1347

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 704

Chain	Residue
A	ALA93
A	ALA94
A	ARG148
A	SER562
B	VAL79
B	THR80

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE NA A 705

Chain	Residue
A	ARG49
A	ASP440
A	MET441
A	PHE446
A	ASP581
A	ILE582
A	HOH831

---

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 706

Chain	Residue
A	GLU347
A	ARG370
A	LYS401
A	GOL710
A	HOH852
A	HOH998
A	HOH1020
A	HOH1334

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 707

Chain	Residue
A	HIS515
A	ASP605
A	LYS610
A	HOH1243
A	HOH1266
A	HOH1340

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 708

Chain	Residue
A	ASP161
A	HIS170
A	VAL197
A	ALA199
B	HOH1265

---

site_id	AC9
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A 709

Chain	Residue
A	ILE39
A	ALA40
A	TYR41
A	LEU42
A	VAL251
A	ILE328
A	SER329
A	ASP330
A	HOH912
A	HOH982

---

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 710

Chain	Residue
A	TRP349
A	ARG370
A	TYR389
A	GLU397
A	GLU399
A	GOL706
A	HOH1334

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CU B 701

Chain	Residue
B	HIS431
B	HIS433
B	HIS592
B	CL702
B	HOH1319

---

site_id	BC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CL B 702

Chain	Residue
B	2TY382
B	HIS431
B	HIS433
B	HIS592
B	MET602
B	CU701
B	HOH1309
B	HOH1319

---

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL B 703

Chain	Residue
B	HIS345
B	SER374
B	TYR387
B	HOH1204

---

site_id	BC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL B 704

Chain	Residue
B	ASP128

---

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA B 705

Chain	Residue
B	ASP440
B	MET441
B	ASP581
B	ILE582
B	HOH885

---

site_id	BC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL B 706

Chain	Residue
B	GLU347
B	ASP348
B	TRP349
B	ARG370
B	LYS401
B	HOH859
B	HOH1076
B	HOH1076

---

Functional Information from PROSITE/UniProt

site_id	PS01164
Number of Residues	14
Details	COPPER_AMINE_OXID_1 Copper amine oxidase topaquinone signature. MVIsfftTigNYDY

Chain	Residue	Details
A	MET371-TYR384

---

site_id	PS01165
Number of Residues	14
Details	COPPER_AMINE_OXID_2 Copper amine oxidase copper-binding site signature. TfGltHFprvEDwP

Chain	Residue	Details
A	THR587-PRO600

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:P12807

Chain	Residue	Details
A	ASP298
B	ASP298

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: Schiff-base intermediate with substrate; via topaquinone => ECO:0000250|UniProtKB:P12807

Chain	Residue	Details
A	2TY382
B	2TY382

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P12807

Chain	Residue	Details
A	TYR296
B	TYR296

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P46883

Chain	Residue	Details
A	ILE379
B	ILE379

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:9405045, ECO:0007744|PDB:1AV4, ECO:0007744|PDB:1AVL, ECO:0007744|PDB:1IU7, ECO:0007744|PDB:1IVU, ECO:0007744|PDB:1IVV, ECO:0007744|PDB:1IVW, ECO:0007744|PDB:1IVX, ECO:0007744|PDB:1RJO, ECO:0007744|PDB:1SIH, ECO:0007744|PDB:1SII, ECO:0007744|PDB:1UI8, ECO:0007744|PDB:1W4N, ECO:0007744|PDB:1W5Z, ECO:0007744|PDB:1W6C, ECO:0007744|PDB:1W6G, ECO:0007744|PDB:2BT3, ECO:0007744|PDB:2CFD, ECO:0007744|PDB:2CFG, ECO:0007744|PDB:2CFK, ECO:0007744|PDB:2CFL, ECO:0007744|PDB:2CFW, ECO:0007744|PDB:2CG0, ECO:0007744|PDB:2CG1, ECO:0007744|PDB:2CWT, ECO:0007744|PDB:2CWU, ECO:0007744|PDB:2CWV, ECO:0007744|PDB:2D1W, ECO:0007744|PDB:2E2T, ECO:0007744|PDB:2E2U, ECO:0007744|PDB:2E2V, ECO:0007744|PDB:2YX9, ECO:0007744|PDB:2ZL8, ECO:0007744|PDB:3AMO, ECO:0007744|PDB:3KII, ECO:0007744|PDB:3KN4, ECO:0007744|PDB:3WA2, ECO:0007744|PDB:3WA3

Chain	Residue	Details
A	HIS431
A	HIS433
A	HIS592
B	HIS431
B	HIS433
B	HIS592

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: 2',4',5'-topaquinone => ECO:0000269|PubMed:9405045

Chain	Residue	Details
A	2TY382
B	2TY382

---