3WZM
ZEN lactonase mutant complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0009636 | biological_process | response to toxic substance |
| A | 0016787 | molecular_function | hydrolase activity |
| B | 0009636 | biological_process | response to toxic substance |
| B | 0016787 | molecular_function | hydrolase activity |
| C | 0009636 | biological_process | response to toxic substance |
| C | 0016787 | molecular_function | hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE ZER A 300 |
| Chain | Residue |
| A | GLY32 |
| A | PRO192 |
| A | PHE221 |
| A | HIS242 |
| A | HOH601 |
| A | LEU33 |
| A | ALA102 |
| A | SER103 |
| A | PRO128 |
| A | MET154 |
| A | TRP183 |
| A | TYR187 |
| A | ILE191 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE ZER B 300 |
| Chain | Residue |
| B | GLY32 |
| B | LEU33 |
| B | ALA102 |
| B | SER103 |
| B | PRO128 |
| B | MET154 |
| B | TRP183 |
| B | TYR187 |
| B | ILE191 |
| B | PRO192 |
| B | HIS242 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE ZER C 300 |
| Chain | Residue |
| C | ASP31 |
| C | GLY32 |
| C | ALA102 |
| C | SER103 |
| C | PRO128 |
| C | LEU135 |
| C | MET154 |
| C | TRP183 |
| C | TYR187 |
| C | PRO188 |
| C | ILE191 |
| C | PRO192 |
| C | PHE221 |
| C | HOH421 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 540 |
| Details | Domain: {"description":"AB hydrolase-1","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"28695844","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2014","firstPage":"62321","lastPage":"62325","volume":"4","journal":"RSC Adv.","title":"Crystal structure and substrate-binding mode of the mycoestrogen-detoxifying lactonase ZHD from Clonostachys rosea.","authors":["Peng W.","Ko T.P.","Yang Y.","Zheng Y.","Chen C.C.","Zhu Z.","Huang C.H.","Zeng Y.F.","Huang J.W.","Wand A.H.-J.","Liu J.R.","Guo R.T."],"citationCrossReferences":[{"database":"DOI","id":"10.1039/c4ra12111b"}]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Active site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2014","firstPage":"62321","lastPage":"62325","volume":"4","journal":"RSC Adv.","title":"Crystal structure and substrate-binding mode of the mycoestrogen-detoxifying lactonase ZHD from Clonostachys rosea.","authors":["Peng W.","Ko T.P.","Yang Y.","Zheng Y.","Chen C.C.","Zhu Z.","Huang C.H.","Zeng Y.F.","Huang J.W.","Wand A.H.-J.","Liu J.R.","Guo R.T."],"citationCrossReferences":[{"database":"DOI","id":"10.1039/c4ra12111b"}]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"28695844","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2014","firstPage":"62321","lastPage":"62325","volume":"4","journal":"RSC Adv.","title":"Crystal structure and substrate-binding mode of the mycoestrogen-detoxifying lactonase ZHD from Clonostachys rosea.","authors":["Peng W.","Ko T.P.","Yang Y.","Zheng Y.","Chen C.C.","Zhu Z.","Huang C.H.","Zeng Y.F.","Huang J.W.","Wand A.H.-J.","Liu J.R.","Guo R.T."],"citationCrossReferences":[{"database":"DOI","id":"10.1039/c4ra12111b"}]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2016","firstPage":"7657","lastPage":"7663","volume":"6","journal":"ACS Catal.","title":"Enhanced alpha-zearalenol hydrolyzing activity of a mycoestrogen-detoxifying lactonase by structure-based engineering.","authors":["Xu Z.X.","Liu W.D.","Chen C.C.","Li Q.","Huang J.W.","Ko T.P.","Liu G.","Liu W.","Peng W.","Cheng Y.S.","Chen Y.","Jin J.","Li H.","Zheng Y.Y.","Guo R.T."],"citationCrossReferences":[{"database":"DOI","id":"10.1021/acscatal.6b01826"}]}},{"source":"PDB","id":"3WZM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5C7Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IE4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IE5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IE6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IE7","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUN-2015","submissionDatabase":"PDB data bank","title":"A case study of lactonase ZHD.","authors":["Ming D.-M.","Qi Q.","Yang W.-J.","Sun K.-L.","Xu T.-Y.","Huang Q.","Hu X.-J.","Lv H."]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"APR-2019","submissionDatabase":"PDB data bank","title":"Structure of ZHD complex.","authors":["Hu X.J.","Zhou H.J.","Li L."]}},{"source":"PDB","id":"5C7Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JRD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2014","firstPage":"62321","lastPage":"62325","volume":"4","journal":"RSC Adv.","title":"Crystal structure and substrate-binding mode of the mycoestrogen-detoxifying lactonase ZHD from Clonostachys rosea.","authors":["Peng W.","Ko T.P.","Yang Y.","Zheng Y.","Chen C.C.","Zhu Z.","Huang C.H.","Zeng Y.F.","Huang J.W.","Wand A.H.-J.","Liu J.R.","Guo R.T."],"citationCrossReferences":[{"database":"DOI","id":"10.1039/c4ra12111b"}]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2016","firstPage":"7657","lastPage":"7663","volume":"6","journal":"ACS Catal.","title":"Enhanced alpha-zearalenol hydrolyzing activity of a mycoestrogen-detoxifying lactonase by structure-based engineering.","authors":["Xu Z.X.","Liu W.D.","Chen C.C.","Li Q.","Huang J.W.","Ko T.P.","Liu G.","Liu W.","Peng W.","Cheng Y.S.","Chen Y.","Jin J.","Li H.","Zheng Y.Y.","Guo R.T."],"citationCrossReferences":[{"database":"DOI","id":"10.1021/acscatal.6b01826"}]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"APR-2019","submissionDatabase":"PDB data bank","title":"Structure of ZHD complex.","authors":["Hu X.J.","Zhou H.J.","Li L."]}},{"source":"PDB","id":"3WZM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IE4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IE5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IE6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IE7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JRD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUN-2015","submissionDatabase":"PDB data bank","title":"A case study of lactonase ZHD.","authors":["Ming D.-M.","Qi Q.","Yang W.-J.","Sun K.-L.","Xu T.-Y.","Huang Q.","Hu X.-J.","Lv H."]}},{"source":"PDB","id":"5C7Y","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"APR-2019","submissionDatabase":"PDB data bank","title":"Structure of ZHD complex.","authors":["Hu X.J.","Zhou H.J.","Li L."]}},{"source":"PDB","id":"6JRD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2014","firstPage":"62321","lastPage":"62325","volume":"4","journal":"RSC Adv.","title":"Crystal structure and substrate-binding mode of the mycoestrogen-detoxifying lactonase ZHD from Clonostachys rosea.","authors":["Peng W.","Ko T.P.","Yang Y.","Zheng Y.","Chen C.C.","Zhu Z.","Huang C.H.","Zeng Y.F.","Huang J.W.","Wand A.H.-J.","Liu J.R.","Guo R.T."],"citationCrossReferences":[{"database":"DOI","id":"10.1039/c4ra12111b"}]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2016","firstPage":"7657","lastPage":"7663","volume":"6","journal":"ACS Catal.","title":"Enhanced alpha-zearalenol hydrolyzing activity of a mycoestrogen-detoxifying lactonase by structure-based engineering.","authors":["Xu Z.X.","Liu W.D.","Chen C.C.","Li Q.","Huang J.W.","Ko T.P.","Liu G.","Liu W.","Peng W.","Cheng Y.S.","Chen Y.","Jin J.","Li H.","Zheng Y.Y.","Guo R.T."],"citationCrossReferences":[{"database":"DOI","id":"10.1021/acscatal.6b01826"}]}},{"source":"PDB","id":"3WZM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IE5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IE6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
