3WA3
Crystal structure of copper amine oxidase from arthrobacter globiformis in N2 condition
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005507 | molecular_function | copper ion binding |
| A | 0008131 | molecular_function | primary methylamine oxidase activity |
| A | 0009308 | biological_process | amine metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016641 | molecular_function | oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048038 | molecular_function | quinone binding |
| B | 0005507 | molecular_function | copper ion binding |
| B | 0008131 | molecular_function | primary methylamine oxidase activity |
| B | 0009308 | biological_process | amine metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016641 | molecular_function | oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0048038 | molecular_function | quinone binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CU A 1001 |
| Chain | Residue |
| A | HIS431 |
| A | HIS433 |
| A | HIS592 |
| A | HOH1451 |
| A | HOH1453 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA A 1002 |
| Chain | Residue |
| A | HOH1108 |
| A | ASP440 |
| A | MET441 |
| A | ASP581 |
| A | ILE582 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PGE A 1003 |
| Chain | Residue |
| A | THR192 |
| A | VAL194 |
| A | PHE195 |
| A | GLU413 |
| A | PEG1019 |
| A | HOH1864 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PGE A 1004 |
| Chain | Residue |
| A | GLU208 |
| A | HOH1875 |
| A | HOH1900 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PGE A 1005 |
| Chain | Residue |
| A | SER416 |
| A | ASP417 |
| A | SER471 |
| A | ARG472 |
| A | EDO1015 |
| A | HOH1223 |
| A | HOH1310 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PG4 A 1006 |
| Chain | Residue |
| A | ASN126 |
| A | ASP128 |
| A | HOH1701 |
| A | HOH1775 |
| A | HOH1777 |
| B | ASP161 |
| B | VAL197 |
| B | PRO198 |
| B | ALA199 |
| B | HOH1391 |
| site_id | AC7 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE PG4 A 1007 |
| Chain | Residue |
| A | PHE105 |
| A | ALA135 |
| A | TRP168 |
| A | TYR296 |
| A | TYR302 |
| A | ASP357 |
| A | LEU358 |
| A | TRP359 |
| A | GLY380 |
| A | ASN381 |
| A | TPQ382 |
| A | PHE407 |
| A | PEG1017 |
| A | HOH1659 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE 1PE A 1008 |
| Chain | Residue |
| A | ILE190 |
| A | ASP191 |
| A | GLY193 |
| A | EDO1012 |
| A | EDO1016 |
| A | HOH1531 |
| A | HOH1613 |
| A | HOH1705 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO A 1009 |
| Chain | Residue |
| A | TYR41 |
| A | GLY43 |
| A | VAL44 |
| A | LEU45 |
| A | ARG61 |
| A | ARG551 |
| A | TYR552 |
| A | PEG1022 |
| A | HOH1205 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 1010 |
| Chain | Residue |
| A | GLY414 |
| A | SER416 |
| A | ASP417 |
| A | HOH1172 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 1011 |
| Chain | Residue |
| A | PRO287 |
| A | GLY463 |
| A | GLU465 |
| A | HOH1495 |
| A | HOH1850 |
| site_id | BC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO A 1012 |
| Chain | Residue |
| A | ARG188 |
| A | 1PE1008 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 1013 |
| Chain | Residue |
| A | THR205 |
| A | ASN363 |
| A | ARG366 |
| A | HOH1210 |
| A | HOH1681 |
| A | HOH1727 |
| site_id | BC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 1014 |
| Chain | Residue |
| A | GLY43 |
| A | VAL44 |
| A | PHE249 |
| A | ASP250 |
| A | HOH1266 |
| A | HOH1293 |
| A | HOH1485 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 1015 |
| Chain | Residue |
| A | SER471 |
| A | ARG472 |
| A | PGE1005 |
| A | HOH1891 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 1016 |
| Chain | Residue |
| A | ARG117 |
| A | ARG188 |
| A | VAL189 |
| A | 1PE1008 |
| site_id | BC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PEG A 1017 |
| Chain | Residue |
| A | PHE105 |
| A | PRO136 |
| A | TYR307 |
| A | THR378 |
| A | ILE379 |
| A | GLY380 |
| A | PG41007 |
| A | HOH1617 |
| site_id | BC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG A 1018 |
| Chain | Residue |
| A | GLU486 |
| A | ASP488 |
| A | ARG493 |
| A | HOH1751 |
| A | HOH1797 |
| site_id | CC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PEG A 1019 |
| Chain | Residue |
| A | PHE195 |
| A | PRO196 |
| A | PRO412 |
| A | GLU413 |
| A | PGE1003 |
| A | HOH1211 |
| A | HOH1227 |
| site_id | CC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PEG A 1020 |
| Chain | Residue |
| A | HIS592 |
| A | PHE593 |
| A | ARG595 |
| A | ASP598 |
| A | ASP605 |
| A | ARG612 |
| A | HOH1244 |
| A | HOH1671 |
| A | HOH1845 |
| site_id | CC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PEG A 1021 |
| Chain | Residue |
| A | TRP349 |
| A | TRP349 |
| A | GLY350 |
| A | ARG370 |
| A | TYR389 |
| A | GLU399 |
| A | LYS401 |
| A | HOH1185 |
| A | HOH1259 |
| A | HOH1662 |
| site_id | CC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PEG A 1022 |
| Chain | Residue |
| A | ARG274 |
| A | ASP548 |
| A | ARG551 |
| A | TYR552 |
| A | EDO1009 |
| A | HOH1677 |
| A | HOH1711 |
| site_id | CC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE HDZ A 1023 |
| Chain | Residue |
| A | ALA487 |
| A | ARG490 |
| A | HOH1159 |
| A | HOH1702 |
| site_id | CC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CU B 1001 |
| Chain | Residue |
| B | HIS431 |
| B | HIS433 |
| B | HIS592 |
| B | EDO1017 |
| B | HOH1479 |
| B | HOH1703 |
| site_id | CC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA B 1002 |
| Chain | Residue |
| B | ASP440 |
| B | MET441 |
| B | ASP581 |
| B | ILE582 |
| B | HOH1116 |
| site_id | CC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PGE B 1003 |
| Chain | Residue |
| B | THR192 |
| B | VAL194 |
| B | PHE195 |
| B | GLU413 |
| B | PEG1024 |
| site_id | CC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PGE B 1004 |
| Chain | Residue |
| B | GLU208 |
| B | GLY211 |
| B | ARG619 |
| B | HOH1691 |
| B | HOH1764 |
| site_id | DC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE PGE B 1005 |
| Chain | Residue |
| B | GLU253 |
| B | ARG274 |
| B | ARG438 |
| B | TYR546 |
| B | ASP548 |
| B | ARG551 |
| B | TYR552 |
| B | EDO1014 |
| B | HOH1200 |
| B | HOH1281 |
| B | HOH1339 |
| B | HOH1711 |
| site_id | DC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PG4 B 1006 |
| Chain | Residue |
| A | ASP161 |
| A | VAL197 |
| A | ALA199 |
| A | HOH1435 |
| A | HOH1443 |
| B | ASP128 |
| B | HOH1445 |
| site_id | DC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE PG4 B 1007 |
| Chain | Residue |
| B | PHE105 |
| B | ALA135 |
| B | LEU137 |
| B | TRP168 |
| B | TRP359 |
| B | GLY380 |
| B | ASN381 |
| B | TPQ382 |
| B | PHE407 |
| B | PEG1019 |
| B | HOH1407 |
| B | HOH1769 |
| site_id | DC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE 1PE B 1008 |
| Chain | Residue |
| B | VAL189 |
| B | ASP191 |
| B | THR192 |
| B | EDO1009 |
| B | HOH1389 |
| B | HOH1707 |
| site_id | DC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 1009 |
| Chain | Residue |
| B | ARG117 |
| B | ARG188 |
| B | VAL189 |
| B | 1PE1008 |
| B | HOH1621 |
| B | HOH1683 |
| site_id | DC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 1010 |
| Chain | Residue |
| B | ASP417 |
| B | SER471 |
| B | HOH1941 |
| site_id | DC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 1011 |
| Chain | Residue |
| B | ALA15 |
| B | GLY43 |
| B | VAL44 |
| B | PHE249 |
| B | ASP250 |
| B | HOH1242 |
| B | HOH1552 |
| site_id | DC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 1012 |
| Chain | Residue |
| B | THR205 |
| B | ASN363 |
| B | TYR364 |
| B | ARG366 |
| B | HOH1704 |
| B | HOH1727 |
| B | HOH1885 |
| site_id | DC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 1013 |
| Chain | Residue |
| B | GLN458 |
| B | THR459 |
| B | PRO462 |
| B | GLY463 |
| B | HOH1659 |
| site_id | EC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO B 1014 |
| Chain | Residue |
| B | TYR41 |
| B | VAL44 |
| B | LEU45 |
| B | ARG61 |
| B | ARG551 |
| B | TYR552 |
| B | PGE1005 |
| B | HOH1123 |
| site_id | EC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO B 1015 |
| Chain | Residue |
| B | TRP349 |
| B | ILE351 |
| B | ASN368 |
| B | ASP393 |
| B | VAL604 |
| B | PEG1021 |
| B | HOH1221 |
| B | HOH1657 |
| B | HOH1767 |
| site_id | EC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 1016 |
| Chain | Residue |
| B | PRO287 |
| B | GLY463 |
| B | GLU465 |
| B | HOH1539 |
| B | HOH1693 |
| site_id | EC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO B 1017 |
| Chain | Residue |
| B | ALA402 |
| B | LEU590 |
| B | HIS592 |
| B | MET602 |
| B | PRO603 |
| B | ASP605 |
| B | CU1001 |
| B | HOH1703 |
| B | HOH1705 |
| site_id | EC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO B 1018 |
| Chain | Residue |
| B | ALA627 |
| B | HOH1704 |
| site_id | EC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PEG B 1019 |
| Chain | Residue |
| B | GLU102 |
| B | PHE105 |
| B | PRO136 |
| B | TYR307 |
| B | THR378 |
| B | ILE379 |
| B | GLY380 |
| B | PG41007 |
| B | HOH1698 |
| site_id | EC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PEG B 1020 |
| Chain | Residue |
| A | ARG71 |
| A | HOH1664 |
| B | ARG13 |
| B | LEU14 |
| B | ALA15 |
| B | SER16 |
| B | SER325 |
| B | VAL327 |
| site_id | EC8 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PEG B 1021 |
| Chain | Residue |
| B | TRP349 |
| B | TRP349 |
| B | ARG370 |
| B | TYR389 |
| B | GLU399 |
| B | LYS401 |
| B | EDO1015 |
| B | HOH1657 |
| B | HOH1744 |
| B | HOH1768 |
| site_id | EC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PEG B 1022 |
| Chain | Residue |
| B | GLU486 |
| B | ASP488 |
| B | ARG493 |
| B | HOH1566 |
| B | HOH1681 |
| B | HOH1923 |
| site_id | FC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG B 1023 |
| Chain | Residue |
| B | ARG472 |
| B | HOH1227 |
| B | HOH1697 |
| B | HOH1756 |
| B | HOH1843 |
| site_id | FC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PEG B 1024 |
| Chain | Residue |
| A | HOH1614 |
| B | PHE195 |
| B | PRO196 |
| B | PRO412 |
| B | GLU413 |
| B | PGE1003 |
| B | HOH1468 |
| B | HOH1656 |
| B | HOH1666 |
| site_id | FC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE HDZ B 1025 |
| Chain | Residue |
| B | ALA487 |
| B | ARG490 |
| B | HOH1136 |
| B | HOH1467 |
Functional Information from PROSITE/UniProt
| site_id | PS01164 |
| Number of Residues | 14 |
| Details | COPPER_AMINE_OXID_1 Copper amine oxidase topaquinone signature. MVIsfftTigNYDY |
| Chain | Residue | Details |
| A | MET371-TYR384 |
| site_id | PS01165 |
| Number of Residues | 14 |
| Details | COPPER_AMINE_OXID_2 Copper amine oxidase copper-binding site signature. TfGltHFprvEDwP |
| Chain | Residue | Details |
| A | THR587-PRO600 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"UniProtKB","id":"P12807","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Schiff-base intermediate with substrate; via topaquinone","evidences":[{"source":"UniProtKB","id":"P12807","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 22 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P12807","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"9405045","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1AV4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1AVL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1IU7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1IVU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1IVV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1IVW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1IVX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RJO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SIH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SII","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1UI8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1W4N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1W5Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1W6C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1W6G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BT3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CFD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CFG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CFK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CFL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CFW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CG0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CG1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CWT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CWU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CWV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2D1W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E2T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E2U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E2V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2YX9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZL8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AMO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KII","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KN4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WA2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WA3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"2',4',5'-topaquinone","evidences":[{"source":"PubMed","id":"9405045","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
