3W82
Human alpha-L-iduronidase in complex with iduronic acid
Functional Information from GO Data
Functional Information from PROSITE/UniProt
site_id | PS01027 |
Number of Residues | 10 |
Details | GLYCOSYL_HYDROL_F39 Glycosyl hydrolases family 39 active site. WnFEtWNEPD |
Chain | Residue | Details |
A | TRP175-ASP184 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton donor => ECO:0000255|PROSITE-ProRule:PRU10068, ECO:0000269|PubMed:24036510 |
Chain | Residue | Details |
A | GLU182 | |
B | GLU182 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | ACT_SITE: Nucleophile => ECO:0000269|PubMed:24036510 |
Chain | Residue | Details |
A | GLU299 | |
B | GLU299 |
site_id | SWS_FT_FI3 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:23959878, ECO:0000269|PubMed:24036510, ECO:0007744|PDB:3W81, ECO:0007744|PDB:3W82, ECO:0007744|PDB:4KGL |
Chain | Residue | Details |
A | PRO54 | |
A | LEU56 | |
A | HIS58 | |
B | PRO54 | |
B | LEU56 | |
B | HIS58 |
site_id | SWS_FT_FI4 |
Number of Residues | 16 |
Details | BINDING: BINDING => ECO:0000269|PubMed:23959878, ECO:0007744|PDB:3W82 |
Chain | Residue | Details |
A | HIS91 | |
B | ASN181 | |
B | GLU182 | |
B | LYS264 | |
B | GLU299 | |
B | GLY305 | |
B | ASP349 | |
B | ARG363 | |
A | ASN181 | |
A | GLU182 | |
A | LYS264 | |
A | GLU299 | |
A | GLY305 | |
A | ASP349 | |
A | ARG363 | |
B | HIS91 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:23959878, ECO:0000269|PubMed:24036510, ECO:0007744|PDB:3W81, ECO:0007744|PDB:3W82, ECO:0007744|PDB:4KGJ, ECO:0007744|PDB:4KH2 |
Chain | Residue | Details |
A | TRP306 | |
B | TRP306 |
site_id | SWS_FT_FI6 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:23959878, ECO:0007744|PDB:3W81, ECO:0007744|PDB:3W82 |
Chain | Residue | Details |
A | ARG488 | |
A | ARG492 | |
B | ARG488 | |
B | ARG492 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:23959878, ECO:0000269|PubMed:24036510, ECO:0007744|PDB:3W81, ECO:0007744|PDB:3W82, ECO:0007744|PDB:4KGJ, ECO:0007744|PDB:4KGL, ECO:0007744|PDB:4KH2, ECO:0007744|PDB:4MJ2, ECO:0007744|PDB:4MJ4 |
Chain | Residue | Details |
A | ASN110 | |
B | ASN110 |
site_id | SWS_FT_FI8 |
Number of Residues | 2 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:23959878, ECO:0007744|PDB:3W81, ECO:0007744|PDB:3W82 |
Chain | Residue | Details |
A | ASN190 | |
B | ASN190 |
site_id | SWS_FT_FI9 |
Number of Residues | 2 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498 |
Chain | Residue | Details |
A | ASN336 | |
B | ASN336 |
site_id | SWS_FT_FI10 |
Number of Residues | 4 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:23959878, ECO:0000269|PubMed:24036510, ECO:0007744|PDB:3W81, ECO:0007744|PDB:3W82, ECO:0007744|PDB:4KGJ, ECO:0007744|PDB:4KGL, ECO:0007744|PDB:4KH2, ECO:0007744|PDB:4MJ2, ECO:0007744|PDB:4MJ4 |
Chain | Residue | Details |
A | ASN372 | |
A | ASN415 | |
B | ASN372 | |
B | ASN415 |
site_id | SWS_FT_FI11 |
Number of Residues | 2 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:23959878, ECO:0007744|PDB:3W81 |
Chain | Residue | Details |
A | ASN451 | |
B | ASN451 |