3VOW

Crystal Structure of the Human APOBEC3C having HIV-1 Vif-binding Interface

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000932	cellular_component	P-body
A	0002376	biological_process	immune system process
A	0003723	molecular_function	RNA binding
A	0003824	molecular_function	catalytic activity
A	0004126	molecular_function	cytidine deaminase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0008270	molecular_function	zinc ion binding
A	0009972	biological_process	obsolete cytidine deamination
A	0010526	biological_process	transposable element silencing
A	0010558	biological_process	negative regulation of macromolecule biosynthetic process
A	0016554	biological_process	cytidine to uridine editing
A	0016787	molecular_function	hydrolase activity
A	0044029	biological_process	positive regulation of gene expression via chromosomal CpG island demethylation
A	0044355	biological_process	clearance of foreign intracellular DNA
A	0045071	biological_process	negative regulation of viral genome replication
A	0045087	biological_process	innate immune response
A	0045869	biological_process	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
A	0046872	molecular_function	metal ion binding
A	0051607	biological_process	defense response to virus
A	0070383	biological_process	DNA cytosine deamination
A	0140546	biological_process	defense response to symbiont
B	0000932	cellular_component	P-body
B	0002376	biological_process	immune system process
B	0003723	molecular_function	RNA binding
B	0003824	molecular_function	catalytic activity
B	0004126	molecular_function	cytidine deaminase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0008270	molecular_function	zinc ion binding
B	0009972	biological_process	obsolete cytidine deamination
B	0010526	biological_process	transposable element silencing
B	0010558	biological_process	negative regulation of macromolecule biosynthetic process
B	0016554	biological_process	cytidine to uridine editing
B	0016787	molecular_function	hydrolase activity
B	0044029	biological_process	positive regulation of gene expression via chromosomal CpG island demethylation
B	0044355	biological_process	clearance of foreign intracellular DNA
B	0045071	biological_process	negative regulation of viral genome replication
B	0045087	biological_process	innate immune response
B	0045869	biological_process	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
B	0046872	molecular_function	metal ion binding
B	0051607	biological_process	defense response to virus
B	0070383	biological_process	DNA cytosine deamination
B	0140546	biological_process	defense response to symbiont

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 201

Chain	Residue
A	HIS66
A	CYS97
A	CYS100
A	HOH331

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 201

Chain	Residue
B	HIS66
B	CYS97
B	CYS100
B	HOH332

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site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B 202

Chain	Residue
B	ARG44
B	LYS43

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Functional Information from PROSITE/UniProt

site_id	PS00903
Number of Residues	39
Details	CYT_DCMP_DEAMINASES_1 Cytidine and deoxycytidylate deaminases zinc-binding region signature. HAErcFLswfcddilspntkyqvtwytsws..........PCpd......CageV

Chain	Residue	Details
A	HIS66-VAL104

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	218
Details	Domain: {"description":"CMP/dCMP-type deaminase","evidences":[{"source":"PROSITE-ProRule","id":"PRU01083","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	92
Details	Region: {"description":"(Microbial infection) Required for interaction with human foamy virus protein Bet","evidences":[{"source":"PubMed","id":"19074429","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PROSITE-ProRule","id":"PRU01083","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PDB","id":"3VM8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3VOW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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