3V96
Complex of matrix metalloproteinase-10 catalytic domain (MMP-10cd) with tissue inhibitor of metalloproteinases-1 (TIMP-1)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002020 | molecular_function | protease binding |
| A | 0004857 | molecular_function | enzyme inhibitor activity |
| A | 0005125 | molecular_function | cytokine activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005604 | cellular_component | basement membrane |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005788 | cellular_component | endoplasmic reticulum lumen |
| A | 0007165 | biological_process | signal transduction |
| A | 0008083 | molecular_function | growth factor activity |
| A | 0008191 | molecular_function | metalloendopeptidase inhibitor activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0008284 | biological_process | positive regulation of cell population proliferation |
| A | 0009725 | biological_process | response to hormone |
| A | 0010951 | biological_process | negative regulation of endopeptidase activity |
| A | 0030414 | molecular_function | peptidase inhibitor activity |
| A | 0031012 | cellular_component | extracellular matrix |
| A | 0031093 | cellular_component | platelet alpha granule lumen |
| A | 0034097 | biological_process | response to cytokine |
| A | 0034774 | cellular_component | secretory granule lumen |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
| A | 0043086 | biological_process | negative regulation of catalytic activity |
| A | 0043434 | biological_process | response to peptide hormone |
| A | 0045861 | biological_process | negative regulation of proteolysis |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051045 | biological_process | negative regulation of membrane protein ectodomain proteolysis |
| A | 0051216 | biological_process | cartilage development |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0071492 | biological_process | cellular response to UV-A |
| A | 1901164 | biological_process | negative regulation of trophoblast cell migration |
| A | 1901653 | biological_process | cellular response to peptide |
| A | 1905049 | biological_process | negative regulation of metallopeptidase activity |
| A | 1905641 | biological_process | cellular response to acetaldehyde |
| A | 2001044 | biological_process | regulation of integrin-mediated signaling pathway |
| B | 0004222 | molecular_function | metalloendopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008237 | molecular_function | metallopeptidase activity |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0031012 | cellular_component | extracellular matrix |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 A 201 |
| Chain | Residue |
| A | ARG59 |
| A | ARG162 |
| A | HIS163 |
| A | HOH351 |
| A | HOH371 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 A 202 |
| Chain | Residue |
| A | HOH370 |
| A | SER100 |
| A | VAL102 |
| A | GLU156 |
| A | LYS157 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 301 |
| Chain | Residue |
| A | CYS1 |
| B | HIS217 |
| B | HIS221 |
| B | HIS227 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 302 |
| Chain | Residue |
| B | HIS167 |
| B | ASP169 |
| B | HIS182 |
| B | HIS195 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 303 |
| Chain | Residue |
| B | ASP174 |
| B | GLY175 |
| B | GLY177 |
| B | SER179 |
| B | ASP197 |
| B | GLU200 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 304 |
| Chain | Residue |
| B | ASP157 |
| B | GLY189 |
| B | TYR191 |
| B | ASP193 |
| B | HOH447 |
| B | HOH449 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA B 305 |
| Chain | Residue |
| B | ASP123 |
| B | ASP198 |
| B | GLU200 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHELGHSL |
| Chain | Residue | Details |
| B | VAL214-LEU223 |
| site_id | PS00288 |
| Number of Residues | 13 |
| Details | TIMP Tissue inhibitors of metalloproteinases signature. CtCvPpHPQtaFC |
| Chain | Residue | Details |
| A | CYS1-CYS13 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 5 |
| Details | Region: {"description":"Involved in metalloproteinase-binding","evidences":[{"source":"PubMed","id":"22427646","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3V96","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22427646","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Site: {"description":"Involved in metalloproteinase-binding","evidences":[{"source":"PubMed","id":"22427646","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3V96","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by FAM20C","evidences":[{"source":"PubMed","id":"26091039","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","featureId":"CAR_000003","evidences":[{"source":"PubMed","id":"16740002","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15095982","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 7 |
| Details | Binding site: {} |
| Chain | Residue | Details |
