3V96
Complex of matrix metalloproteinase-10 catalytic domain (MMP-10cd) with tissue inhibitor of metalloproteinases-1 (TIMP-1)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0002020 | molecular_function | protease binding |
A | 0002248 | biological_process | connective tissue replacement involved in inflammatory response wound healing |
A | 0004857 | molecular_function | enzyme inhibitor activity |
A | 0005125 | molecular_function | cytokine activity |
A | 0005515 | molecular_function | protein binding |
A | 0005576 | cellular_component | extracellular region |
A | 0005604 | cellular_component | basement membrane |
A | 0005615 | cellular_component | extracellular space |
A | 0005788 | cellular_component | endoplasmic reticulum lumen |
A | 0007165 | biological_process | signal transduction |
A | 0008083 | molecular_function | growth factor activity |
A | 0008191 | molecular_function | metalloendopeptidase inhibitor activity |
A | 0008270 | molecular_function | zinc ion binding |
A | 0008284 | biological_process | positive regulation of cell population proliferation |
A | 0009725 | biological_process | response to hormone |
A | 0010033 | biological_process | response to organic substance |
A | 0010951 | biological_process | negative regulation of endopeptidase activity |
A | 0030414 | molecular_function | peptidase inhibitor activity |
A | 0031012 | cellular_component | extracellular matrix |
A | 0031093 | cellular_component | platelet alpha granule lumen |
A | 0034097 | biological_process | response to cytokine |
A | 0043066 | biological_process | negative regulation of apoptotic process |
A | 0043086 | biological_process | negative regulation of catalytic activity |
A | 0043434 | biological_process | response to peptide hormone |
A | 0046872 | molecular_function | metal ion binding |
A | 0051045 | biological_process | negative regulation of membrane protein ectodomain proteolysis |
A | 0051216 | biological_process | cartilage development |
A | 0070062 | cellular_component | extracellular exosome |
A | 0071492 | biological_process | cellular response to UV-A |
A | 1901164 | biological_process | negative regulation of trophoblast cell migration |
A | 1905049 | biological_process | negative regulation of metallopeptidase activity |
A | 2001044 | biological_process | regulation of integrin-mediated signaling pathway |
B | 0004222 | molecular_function | metalloendopeptidase activity |
B | 0006508 | biological_process | proteolysis |
B | 0008237 | molecular_function | metallopeptidase activity |
B | 0008270 | molecular_function | zinc ion binding |
B | 0031012 | cellular_component | extracellular matrix |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PO4 A 201 |
Chain | Residue |
A | ARG59 |
A | ARG162 |
A | HIS163 |
A | HOH351 |
A | HOH371 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PO4 A 202 |
Chain | Residue |
A | HOH370 |
A | SER100 |
A | VAL102 |
A | GLU156 |
A | LYS157 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN B 301 |
Chain | Residue |
A | CYS1 |
B | HIS217 |
B | HIS221 |
B | HIS227 |
site_id | AC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN B 302 |
Chain | Residue |
B | HIS167 |
B | ASP169 |
B | HIS182 |
B | HIS195 |
site_id | AC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA B 303 |
Chain | Residue |
B | ASP174 |
B | GLY175 |
B | GLY177 |
B | SER179 |
B | ASP197 |
B | GLU200 |
site_id | AC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA B 304 |
Chain | Residue |
B | ASP157 |
B | GLY189 |
B | TYR191 |
B | ASP193 |
B | HOH447 |
B | HOH449 |
site_id | AC7 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CA B 305 |
Chain | Residue |
B | ASP123 |
B | ASP198 |
B | GLU200 |
Functional Information from PROSITE/UniProt
site_id | PS00142 |
Number of Residues | 10 |
Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHELGHSL |
Chain | Residue | Details |
B | VAL214-LEU223 |
site_id | PS00288 |
Number of Residues | 13 |
Details | TIMP Tissue inhibitors of metalloproteinases signature. CtCvPpHPQtaFC |
Chain | Residue | Details |
A | CYS1-CYS13 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000269|PubMed:15095982 |
Chain | Residue | Details |
B | GLU218 |
site_id | SWS_FT_FI2 |
Number of Residues | 7 |
Details | BINDING: |
Chain | Residue | Details |
B | HIS167 | |
B | ASP169 | |
B | HIS182 | |
B | HIS195 | |
B | HIS217 | |
B | HIS221 | |
B | HIS227 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine; by FAM20C => ECO:0000269|PubMed:26091039 |
Chain | Residue | Details |
A | SER155 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16263699, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:16740002, ECO:0000269|PubMed:19139490 |
Chain | Residue | Details |
A | ALA30 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16740002 |
Chain | Residue | Details |
A | ASN78 |