3V5O

Structural and Mechanistic Studies of Catalysis and Sulfa Drug Resistance in Dihydropteroate Synthase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004156	molecular_function	dihydropteroate synthase activity
A	0009396	biological_process	folic acid-containing compound biosynthetic process
A	0042558	biological_process	pteridine-containing compound metabolic process
B	0004156	molecular_function	dihydropteroate synthase activity
B	0009396	biological_process	folic acid-containing compound biosynthetic process
B	0042558	biological_process	pteridine-containing compound metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 301

Chain	Residue
A	ARG254
A	HIS256

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site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 A 302

Chain	Residue
A	ARG219

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site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 303

Chain	Residue
A	LYS50
A	ARG53

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site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 304

Chain	Residue
A	SER221
A	ARG234

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site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 305

Chain	Residue
A	LEU229
A	ARG263

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site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 301

Chain	Residue
B	ARG254
B	HIS256

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site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 302

Chain	Residue
B	LYS50
B	ARG53

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site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 303

Chain	Residue
B	LEU229
B	ARG263

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site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 304

Chain	Residue
B	SER221
B	ARG234

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site_id	BC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 B 305

Chain	Residue
B	ARG219

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site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 306

Chain	Residue
B	ARG201
B	ASN202

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Functional Information from PROSITE/UniProt

site_id	PS00792
Number of Residues	16
Details	DHPS_1 Dihydropteroate synthase signature 1. ImGILNvTpDSFsDgG

Chain	Residue	Details
A	ILE22-GLY37

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site_id	PS00793
Number of Residues	14
Details	DHPS_2 Dihydropteroate synthase signature 2. GAhIIDIGGesTrP

Chain	Residue	Details
A	GLY56-PRO69

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