Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3US2

Structure of p63 DNA Binding Domain in Complex with a 19 Base Pair A/T Rich Response Element Containing Two Half Sites with a Single Base Pair Overlap

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000976	molecular_function	transcription cis-regulatory region binding
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006915	biological_process	apoptotic process
B	0000976	molecular_function	transcription cis-regulatory region binding
B	0003677	molecular_function	DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0005634	cellular_component	nucleus
B	0006355	biological_process	regulation of DNA-templated transcription
B	0006915	biological_process	apoptotic process
C	0000976	molecular_function	transcription cis-regulatory region binding
C	0003677	molecular_function	DNA binding
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0005634	cellular_component	nucleus
C	0006355	biological_process	regulation of DNA-templated transcription
C	0006915	biological_process	apoptotic process
D	0000976	molecular_function	transcription cis-regulatory region binding
D	0003677	molecular_function	DNA binding
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0005634	cellular_component	nucleus
D	0006355	biological_process	regulation of DNA-templated transcription
D	0006915	biological_process	apoptotic process
G	0000976	molecular_function	transcription cis-regulatory region binding
G	0003677	molecular_function	DNA binding
G	0003700	molecular_function	DNA-binding transcription factor activity
G	0005634	cellular_component	nucleus
G	0006355	biological_process	regulation of DNA-templated transcription
G	0006915	biological_process	apoptotic process
H	0000976	molecular_function	transcription cis-regulatory region binding
H	0003677	molecular_function	DNA binding
H	0003700	molecular_function	DNA-binding transcription factor activity
H	0005634	cellular_component	nucleus
H	0006355	biological_process	regulation of DNA-templated transcription
H	0006915	biological_process	apoptotic process
I	0000976	molecular_function	transcription cis-regulatory region binding
I	0003677	molecular_function	DNA binding
I	0003700	molecular_function	DNA-binding transcription factor activity
I	0005634	cellular_component	nucleus
I	0006355	biological_process	regulation of DNA-templated transcription
I	0006915	biological_process	apoptotic process
J	0000976	molecular_function	transcription cis-regulatory region binding
J	0003677	molecular_function	DNA binding
J	0003700	molecular_function	DNA-binding transcription factor activity
J	0005634	cellular_component	nucleus
J	0006355	biological_process	regulation of DNA-templated transcription
J	0006915	biological_process	apoptotic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 901

Chain	Residue
A	CYS205
A	HIS208
A	CYS269
A	CYS273

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 901

Chain	Residue
B	CYS205
B	HIS208
B	CYS269
B	CYS273

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 901

Chain	Residue
C	HIS208
C	CYS269
C	CYS273
C	CYS205

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 901

Chain	Residue
D	CYS205
D	HIS208
D	CYS269
D	CYS273

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN G 901

Chain	Residue
G	CYS205
G	HIS208
G	CYS269
G	CYS273

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 901

Chain	Residue
H	CYS205
H	HIS208
H	CYS269
H	CYS273

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN I 901

Chain	Residue
I	CYS205
I	HIS208
I	CYS269
I	CYS273

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN J 901

Chain	Residue
J	CYS205
J	HIS208
J	CYS269
J	CYS273

Functional Information from PROSITE/UniProt

site_id	PS00348
Number of Residues	13
Details	P53 p53 family signature. MCNSSCVGGMNRR

Chain	Residue	Details
A	MET268-ARG280

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1536
Details	DNA_BIND:

Chain	Residue	Details
A	ASP131-GLN323
B	ASP131-GLN323
C	ASP131-GLN323
D	ASP131-GLN323
G	ASP131-GLN323
H	ASP131-GLN323
I	ASP131-GLN323
J	ASP131-GLN323

site_id	SWS_FT_FI2
Number of Residues	32
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	CYS205
C	HIS208
C	CYS269
C	CYS273
D	CYS205
D	HIS208
D	CYS269
D	CYS273
G	CYS205
G	HIS208
G	CYS269
A	HIS208
G	CYS273
H	CYS205
H	HIS208
H	CYS269
H	CYS273
I	CYS205
I	HIS208
I	CYS269
I	CYS273
J	CYS205
A	CYS269
J	HIS208
J	CYS269
J	CYS273
A	CYS273
B	CYS205
B	HIS208
B	CYS269
B	CYS273
C	CYS205

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)