3UPF
Crystal structure of murine norovirus RNA-dependent RNA polymerase bound to NF023
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
| A | 0004386 | molecular_function | helicase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006351 | biological_process | DNA-templated transcription |
| A | 0039694 | biological_process | viral RNA genome replication |
| B | 0003723 | molecular_function | RNA binding |
| B | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
| B | 0004386 | molecular_function | helicase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006351 | biological_process | DNA-templated transcription |
| B | 0039694 | biological_process | viral RNA genome replication |
| C | 0003723 | molecular_function | RNA binding |
| C | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
| C | 0004386 | molecular_function | helicase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006351 | biological_process | DNA-templated transcription |
| C | 0039694 | biological_process | viral RNA genome replication |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE 0BU A 600 |
| Chain | Residue |
| A | TRP42 |
| A | ARG182 |
| A | ARG245 |
| A | ARG392 |
| A | ARG413 |
| A | SO4516 |
| A | HOH687 |
| A | ASP65 |
| A | GLN66 |
| A | PRO69 |
| A | GLU168 |
| A | VAL170 |
| A | LYS171 |
| A | LYS174 |
| A | LYS180 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 516 |
| Chain | Residue |
| A | THR244 |
| A | ARG245 |
| A | HOH560 |
| A | 0BU600 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE 0BU B 600 |
| Chain | Residue |
| B | TRP42 |
| B | ASP65 |
| B | GLN66 |
| B | LYS68 |
| B | PRO69 |
| B | GLU168 |
| B | VAL170 |
| B | LYS171 |
| B | LYS174 |
| B | LYS178 |
| B | LYS180 |
| B | ARG182 |
| B | ARG245 |
| B | ARG392 |
| B | ARG413 |
| B | SO4517 |
| B | HOH608 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 516 |
| Chain | Residue |
| B | VAL322 |
| B | ARG326 |
| B | ASP328 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 517 |
| Chain | Residue |
| B | TYR243 |
| B | THR244 |
| B | ARG245 |
| B | 0BU600 |
| B | HOH608 |
| site_id | AC6 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE 0BU C 600 |
| Chain | Residue |
| C | TRP42 |
| C | ASP65 |
| C | GLN66 |
| C | LYS68 |
| C | PRO69 |
| C | GLU168 |
| C | VAL170 |
| C | LYS171 |
| C | LYS174 |
| C | LYS178 |
| C | LYS180 |
| C | ARG182 |
| C | ARG245 |
| C | ARG392 |
| C | SO4516 |
| C | HOH743 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C 516 |
| Chain | Residue |
| C | TYR243 |
| C | THR244 |
| C | ARG245 |
| C | HOH520 |
| C | 0BU600 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 517 |
| Chain | Residue |
| C | GLY7 |
| C | ALA10 |
| C | ARG64 |
| C | HOH633 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 C 518 |
| Chain | Residue |
| C | VAL322 |
| C | ARG326 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 C 519 |
| Chain | Residue |
| C | THR25 |
| C | GLY48 |
| C | SER49 |
| C | SER58 |
| C | LEU59 |
| C | HOH610 |
| C | HOH695 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21471315, ECO:0000269|PubMed:22341781, ECO:0000269|PubMed:24622391 |
| Chain | Residue | Details |
| A | ASP240 | |
| A | GLU345 | |
| B | ASP240 | |
| B | GLU345 | |
| C | ASP240 | |
| C | GLU345 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21471315 |
| Chain | Residue | Details |
| A | ASP242 | |
| B | ASP242 | |
| C | ASP242 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21471315, ECO:0000269|PubMed:24622391 |
| Chain | Residue | Details |
| A | ASP344 | |
| B | ASP344 | |
| C | ASP344 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22341781, ECO:0000269|PubMed:24622391 |
| Chain | Residue | Details |
| A | SER389 | |
| B | SER389 | |
| C | SER389 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | SITE: Cleavage; by 3CLpro => ECO:0000269|PubMed:16873239, ECO:0000269|PubMed:26363064 |
| Chain | Residue | Details |
| A | GLN-3 | |
| B | GLN-3 | |
| C | GLN-3 |
