3UPF
Crystal structure of murine norovirus RNA-dependent RNA polymerase bound to NF023
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003723 | molecular_function | RNA binding |
A | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
A | 0004386 | molecular_function | helicase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0006351 | biological_process | DNA-templated transcription |
A | 0039694 | biological_process | viral RNA genome replication |
B | 0003723 | molecular_function | RNA binding |
B | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
B | 0004386 | molecular_function | helicase activity |
B | 0005524 | molecular_function | ATP binding |
B | 0006351 | biological_process | DNA-templated transcription |
B | 0039694 | biological_process | viral RNA genome replication |
C | 0003723 | molecular_function | RNA binding |
C | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
C | 0004386 | molecular_function | helicase activity |
C | 0005524 | molecular_function | ATP binding |
C | 0006351 | biological_process | DNA-templated transcription |
C | 0039694 | biological_process | viral RNA genome replication |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE 0BU A 600 |
Chain | Residue |
A | TRP42 |
A | ARG182 |
A | ARG245 |
A | ARG392 |
A | ARG413 |
A | SO4516 |
A | HOH687 |
A | ASP65 |
A | GLN66 |
A | PRO69 |
A | GLU168 |
A | VAL170 |
A | LYS171 |
A | LYS174 |
A | LYS180 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 A 516 |
Chain | Residue |
A | THR244 |
A | ARG245 |
A | HOH560 |
A | 0BU600 |
site_id | AC3 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE 0BU B 600 |
Chain | Residue |
B | TRP42 |
B | ASP65 |
B | GLN66 |
B | LYS68 |
B | PRO69 |
B | GLU168 |
B | VAL170 |
B | LYS171 |
B | LYS174 |
B | LYS178 |
B | LYS180 |
B | ARG182 |
B | ARG245 |
B | ARG392 |
B | ARG413 |
B | SO4517 |
B | HOH608 |
site_id | AC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 B 516 |
Chain | Residue |
B | VAL322 |
B | ARG326 |
B | ASP328 |
site_id | AC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 B 517 |
Chain | Residue |
B | TYR243 |
B | THR244 |
B | ARG245 |
B | 0BU600 |
B | HOH608 |
site_id | AC6 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE 0BU C 600 |
Chain | Residue |
C | TRP42 |
C | ASP65 |
C | GLN66 |
C | LYS68 |
C | PRO69 |
C | GLU168 |
C | VAL170 |
C | LYS171 |
C | LYS174 |
C | LYS178 |
C | LYS180 |
C | ARG182 |
C | ARG245 |
C | ARG392 |
C | SO4516 |
C | HOH743 |
site_id | AC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 C 516 |
Chain | Residue |
C | TYR243 |
C | THR244 |
C | ARG245 |
C | HOH520 |
C | 0BU600 |
site_id | AC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 C 517 |
Chain | Residue |
C | GLY7 |
C | ALA10 |
C | ARG64 |
C | HOH633 |
site_id | AC9 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE SO4 C 518 |
Chain | Residue |
C | VAL322 |
C | ARG326 |
site_id | BC1 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE SO4 C 519 |
Chain | Residue |
C | THR25 |
C | GLY48 |
C | SER49 |
C | SER58 |
C | LEU59 |
C | HOH610 |
C | HOH695 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:21471315, ECO:0000269|PubMed:22341781, ECO:0000269|PubMed:24622391 |
Chain | Residue | Details |
A | ASP240 | |
A | GLU345 | |
B | ASP240 | |
B | GLU345 | |
C | ASP240 | |
C | GLU345 |
site_id | SWS_FT_FI2 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:21471315 |
Chain | Residue | Details |
A | ASP242 | |
B | ASP242 | |
C | ASP242 |
site_id | SWS_FT_FI3 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:21471315, ECO:0000269|PubMed:24622391 |
Chain | Residue | Details |
A | ASP344 | |
B | ASP344 | |
C | ASP344 |
site_id | SWS_FT_FI4 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22341781, ECO:0000269|PubMed:24622391 |
Chain | Residue | Details |
A | SER389 | |
B | SER389 | |
C | SER389 |
site_id | SWS_FT_FI5 |
Number of Residues | 3 |
Details | SITE: Cleavage; by 3CLpro => ECO:0000269|PubMed:16873239, ECO:0000269|PubMed:26363064 |
Chain | Residue | Details |
A | GLN-3 | |
B | GLN-3 | |
C | GLN-3 |