3UMI

X-ray structure of the E2 domain of the human amyloid precursor protein (APP) in complex with zinc

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT A 601

Chain	Residue
A	CD6
A	GLU362
A	GLU365
A	HOH767

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1

Chain	Residue
A	HOH79
A	HIS382
A	HIS432
A	HIS436

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CD A 2

Chain	Residue
A	GLU387
A	ASN391
A	ASP429
A	HIS458
A	HOH33

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CD A 3

Chain	Residue
A	ASP444
A	HOH732

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD A 4

Chain	Residue
A	GLU399
A	HIS439
A	HOH747
A	HOH748

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD A 5

Chain	Residue
A	HIS327
A	GLU368
A	ASP392
A	HOH711

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CD A 6

Chain	Residue
A	GLU362
A	GLU365
A	ACT601

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CD A 7

Chain	Residue
A	GLU329
A	GLN484
A	ASP488

---

site_id	AC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CD A 8

Chain	Residue
A	HIS359

---

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CD A 9

Chain	Residue
A	GLU321
A	ASN400

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	63
Details	Region: {"description":"Heparin-binding"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	17
Details	Region: {"description":"Collagen-binding","evidences":[{"source":"PubMed","id":"8576160","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by FAM20C","evidences":[{"source":"PubMed","id":"26091039","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"26091039","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---