3UKM
Crystal structure of the human two pore domain potassium ion channel K2P1 (TWIK-1)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005267 | molecular_function | potassium channel activity |
| A | 0016020 | cellular_component | membrane |
| A | 0071805 | biological_process | potassium ion transmembrane transport |
| B | 0005267 | molecular_function | potassium channel activity |
| B | 0016020 | cellular_component | membrane |
| B | 0071805 | biological_process | potassium ion transmembrane transport |
| C | 0005267 | molecular_function | potassium channel activity |
| C | 0016020 | cellular_component | membrane |
| C | 0071805 | biological_process | potassium ion transmembrane transport |
| D | 0005267 | molecular_function | potassium channel activity |
| D | 0016020 | cellular_component | membrane |
| D | 0071805 | biological_process | potassium ion transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE K A 1 |
| Chain | Residue |
| A | K2 |
| A | GLY119 |
| A | TYR120 |
| A | GLY227 |
| A | LEU228 |
| B | GLY119 |
| B | TYR120 |
| B | GLY227 |
| B | LEU228 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE K A 2 |
| Chain | Residue |
| A | K1 |
| A | K3 |
| A | THR118 |
| A | GLY119 |
| A | ILE226 |
| A | GLY227 |
| B | THR118 |
| B | GLY119 |
| B | ILE226 |
| B | GLY227 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE K A 3 |
| Chain | Residue |
| A | K2 |
| A | K4 |
| A | THR117 |
| A | THR118 |
| A | THR225 |
| A | ILE226 |
| B | THR117 |
| B | THR118 |
| B | THR225 |
| B | ILE226 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K A 4 |
| Chain | Residue |
| A | K3 |
| A | THR117 |
| A | THR225 |
| B | THR117 |
| B | THR225 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE K C 1 |
| Chain | Residue |
| C | K2 |
| C | GLY119 |
| C | TYR120 |
| C | GLY227 |
| C | LEU228 |
| D | GLY119 |
| D | TYR120 |
| D | GLY227 |
| D | LEU228 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE K C 2 |
| Chain | Residue |
| C | K1 |
| C | K3 |
| C | THR118 |
| C | GLY119 |
| C | ILE226 |
| C | GLY227 |
| D | THR118 |
| D | GLY119 |
| D | ILE226 |
| D | GLY227 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE K C 3 |
| Chain | Residue |
| C | K2 |
| C | K4 |
| C | THR117 |
| C | THR118 |
| C | THR225 |
| C | ILE226 |
| D | THR117 |
| D | THR118 |
| D | THR225 |
| D | ILE226 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K C 4 |
| Chain | Residue |
| C | K3 |
| C | THR117 |
| C | THR225 |
| D | THR117 |
| D | THR225 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 344 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"22282804","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 48 |
| Details | Intramembrane: {"description":"Helical; Name=Pore helix 1","evidences":[{"source":"PubMed","id":"22282804","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 44 |
| Details | Intramembrane: {"evidences":[{"source":"PubMed","id":"22282804","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 112 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"22282804","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 48 |
| Details | Intramembrane: {"description":"Helical; Name=Pore helix 2","evidences":[{"source":"PubMed","id":"22282804","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | Region: {"description":"Selectivity filter 1","evidences":[{"source":"PubMed","id":"22282804","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21653227","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 20 |
| Details | Region: {"description":"Selectivity filter 2","evidences":[{"source":"PubMed","id":"22282804","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | Site: {"description":"Important for increased permeability to Na(+) when K(+) levels are subphysiological","evidences":[{"source":"PubMed","id":"21653227","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | Site: {"description":"Part of a hydrophobic barrier that is stochastically dewetted and limits ion permeability","evidences":[{"source":"PubMed","id":"22431633","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25001086","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | Site: {"description":"Part of a hydrophobic barrier that is stochastically dewetted and limits ion permeability","evidences":[{"source":"PubMed","id":"25001086","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 8 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"PubMed","id":"15820677","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20498050","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
