3UK6

Crystal Structure of the Tip48 (Tip49b) hexamer

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0008094	molecular_function	ATP-dependent activity, acting on DNA
B	0005524	molecular_function	ATP binding
B	0008094	molecular_function	ATP-dependent activity, acting on DNA
C	0005524	molecular_function	ATP binding
C	0008094	molecular_function	ATP-dependent activity, acting on DNA
D	0005524	molecular_function	ATP binding
D	0008094	molecular_function	ATP-dependent activity, acting on DNA
E	0005524	molecular_function	ATP binding
E	0008094	molecular_function	ATP-dependent activity, acting on DNA
F	0005524	molecular_function	ATP binding
F	0008094	molecular_function	ATP-dependent activity, acting on DNA
G	0005524	molecular_function	ATP binding
G	0008094	molecular_function	ATP-dependent activity, acting on DNA
H	0005524	molecular_function	ATP binding
H	0008094	molecular_function	ATP-dependent activity, acting on DNA
I	0005524	molecular_function	ATP binding
I	0008094	molecular_function	ATP-dependent activity, acting on DNA
J	0005524	molecular_function	ATP binding
J	0008094	molecular_function	ATP-dependent activity, acting on DNA
K	0005524	molecular_function	ATP binding
K	0008094	molecular_function	ATP-dependent activity, acting on DNA
L	0005524	molecular_function	ATP binding
L	0008094	molecular_function	ATP-dependent activity, acting on DNA

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ADP A 1450

Chain	Residue
A	ALA24
A	LYS83
A	THR84
A	ALA85
A	TYR362
A	LEU399
A	ILE403
A	HIS25
A	HIS27
A	GLY45
A	MET46
A	VAL47
A	GLY80
A	THR81
A	GLY82

---

site_id	AC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ADP B 1450

Chain	Residue
B	ALA24
B	HIS25
B	HIS27
B	ILE28
B	GLY45
B	MET46
B	VAL47
B	GLY80
B	THR81
B	GLY82
B	LYS83
B	THR84
B	ALA85
B	TYR362
B	LEU399
B	ILE403

---

site_id	AC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ADP J 1450

Chain	Residue
J	ALA24
J	HIS25
J	HIS27
J	GLY45
J	VAL47
J	PRO79
J	GLY80
J	THR81
J	GLY82
J	LYS83
J	THR84
J	ALA85
J	TYR362
J	ILE403

---

site_id	AC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ADP C 1450

Chain	Residue
C	ALA24
C	HIS25
C	HIS27
C	GLY45
C	MET46
C	VAL47
C	GLY80
C	THR81
C	GLY82
C	LYS83
C	THR84
C	ALA85
C	TYR362
C	LEU399

---

site_id	AC5
Number of Residues	13
Details	BINDING SITE FOR RESIDUE ADP I 1450

Chain	Residue
I	ALA24
I	HIS25
I	HIS27
I	GLY45
I	MET46
I	VAL47
I	GLY80
I	THR81
I	GLY82
I	LYS83
I	THR84
I	ALA85
I	TYR362

---

site_id	AC6
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ADP D 1450

Chain	Residue
D	ALA24
D	HIS25
D	HIS27
D	GLY45
D	MET46
D	VAL47
D	GLY80
D	THR81
D	GLY82
D	LYS83
D	THR84
D	ALA85
D	TYR362
D	ILE370
D	LEU399
D	ILE403

---

site_id	AC7
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ADP H 1450

Chain	Residue
H	ALA85
H	TYR362
H	LEU399
H	ILE403
H	ALA24
H	HIS25
H	HIS27
H	GLY45
H	MET46
H	VAL47
H	GLY80
H	THR81
H	GLY82
H	LYS83
H	THR84

---

site_id	AC8
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ADP F 1450

Chain	Residue
F	ALA24
F	HIS25
F	HIS27
F	GLY45
F	VAL47
F	GLY80
F	THR81
F	GLY82
F	LYS83
F	THR84
F	ALA85
F	TYR362
F	ILE370
F	LEU399
F	ILE403

---

site_id	AC9
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ADP K 1450

Chain	Residue
K	ALA24
K	HIS25
K	HIS27
K	ILE28
K	GLY45
K	MET46
K	VAL47
K	THR81
K	GLY82
K	LYS83
K	THR84
K	ALA85
K	TYR362
K	ILE403

---

site_id	BC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ADP E 1450

Chain	Residue
E	ALA24
E	HIS25
E	HIS27
E	GLY45
E	MET46
E	VAL47
E	GLY80
E	THR81
E	GLY82
E	LYS83
E	THR84
E	ALA85
E	TYR362
E	ILE370
E	LEU399
E	ILE403

---

site_id	BC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE ADP L 1450

Chain	Residue
L	GLY80
L	THR81
L	GLY82
L	LYS83
L	THR84
L	ALA85
L	TYR362
L	LEU399

---

site_id	BC3
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ADP G 1450

Chain	Residue
G	ALA24
G	HIS25
G	HIS27
G	GLY45
G	MET46
G	VAL47
G	GLY80
G	THR81
G	GLY82
G	LYS83
G	THR84
G	ALA85
G	TYR362
G	ILE370
G	LEU399
G	ILE403

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	77
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---