3UK6
Crystal Structure of the Tip48 (Tip49b) hexamer
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005524 | molecular_function | ATP binding |
| A | 0008094 | molecular_function | ATP-dependent activity, acting on DNA |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0008094 | molecular_function | ATP-dependent activity, acting on DNA |
| B | 0016887 | molecular_function | ATP hydrolysis activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0008094 | molecular_function | ATP-dependent activity, acting on DNA |
| C | 0016887 | molecular_function | ATP hydrolysis activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0008094 | molecular_function | ATP-dependent activity, acting on DNA |
| D | 0016887 | molecular_function | ATP hydrolysis activity |
| E | 0005524 | molecular_function | ATP binding |
| E | 0008094 | molecular_function | ATP-dependent activity, acting on DNA |
| E | 0016887 | molecular_function | ATP hydrolysis activity |
| F | 0005524 | molecular_function | ATP binding |
| F | 0008094 | molecular_function | ATP-dependent activity, acting on DNA |
| F | 0016887 | molecular_function | ATP hydrolysis activity |
| G | 0005524 | molecular_function | ATP binding |
| G | 0008094 | molecular_function | ATP-dependent activity, acting on DNA |
| G | 0016887 | molecular_function | ATP hydrolysis activity |
| H | 0005524 | molecular_function | ATP binding |
| H | 0008094 | molecular_function | ATP-dependent activity, acting on DNA |
| H | 0016887 | molecular_function | ATP hydrolysis activity |
| I | 0005524 | molecular_function | ATP binding |
| I | 0008094 | molecular_function | ATP-dependent activity, acting on DNA |
| I | 0016887 | molecular_function | ATP hydrolysis activity |
| J | 0005524 | molecular_function | ATP binding |
| J | 0008094 | molecular_function | ATP-dependent activity, acting on DNA |
| J | 0016887 | molecular_function | ATP hydrolysis activity |
| K | 0005524 | molecular_function | ATP binding |
| K | 0008094 | molecular_function | ATP-dependent activity, acting on DNA |
| K | 0016887 | molecular_function | ATP hydrolysis activity |
| L | 0005524 | molecular_function | ATP binding |
| L | 0008094 | molecular_function | ATP-dependent activity, acting on DNA |
| L | 0016887 | molecular_function | ATP hydrolysis activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE ADP A 1450 |
| Chain | Residue |
| A | ALA24 |
| A | LYS83 |
| A | THR84 |
| A | ALA85 |
| A | TYR362 |
| A | LEU399 |
| A | ILE403 |
| A | HIS25 |
| A | HIS27 |
| A | GLY45 |
| A | MET46 |
| A | VAL47 |
| A | GLY80 |
| A | THR81 |
| A | GLY82 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE ADP B 1450 |
| Chain | Residue |
| B | ALA24 |
| B | HIS25 |
| B | HIS27 |
| B | ILE28 |
| B | GLY45 |
| B | MET46 |
| B | VAL47 |
| B | GLY80 |
| B | THR81 |
| B | GLY82 |
| B | LYS83 |
| B | THR84 |
| B | ALA85 |
| B | TYR362 |
| B | LEU399 |
| B | ILE403 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE ADP J 1450 |
| Chain | Residue |
| J | ALA24 |
| J | HIS25 |
| J | HIS27 |
| J | GLY45 |
| J | VAL47 |
| J | PRO79 |
| J | GLY80 |
| J | THR81 |
| J | GLY82 |
| J | LYS83 |
| J | THR84 |
| J | ALA85 |
| J | TYR362 |
| J | ILE403 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE ADP C 1450 |
| Chain | Residue |
| C | ALA24 |
| C | HIS25 |
| C | HIS27 |
| C | GLY45 |
| C | MET46 |
| C | VAL47 |
| C | GLY80 |
| C | THR81 |
| C | GLY82 |
| C | LYS83 |
| C | THR84 |
| C | ALA85 |
| C | TYR362 |
| C | LEU399 |
| site_id | AC5 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE ADP I 1450 |
| Chain | Residue |
| I | ALA24 |
| I | HIS25 |
| I | HIS27 |
| I | GLY45 |
| I | MET46 |
| I | VAL47 |
| I | GLY80 |
| I | THR81 |
| I | GLY82 |
| I | LYS83 |
| I | THR84 |
| I | ALA85 |
| I | TYR362 |
| site_id | AC6 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE ADP D 1450 |
| Chain | Residue |
| D | ALA24 |
| D | HIS25 |
| D | HIS27 |
| D | GLY45 |
| D | MET46 |
| D | VAL47 |
| D | GLY80 |
| D | THR81 |
| D | GLY82 |
| D | LYS83 |
| D | THR84 |
| D | ALA85 |
| D | TYR362 |
| D | ILE370 |
| D | LEU399 |
| D | ILE403 |
| site_id | AC7 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE ADP H 1450 |
| Chain | Residue |
| H | ALA85 |
| H | TYR362 |
| H | LEU399 |
| H | ILE403 |
| H | ALA24 |
| H | HIS25 |
| H | HIS27 |
| H | GLY45 |
| H | MET46 |
| H | VAL47 |
| H | GLY80 |
| H | THR81 |
| H | GLY82 |
| H | LYS83 |
| H | THR84 |
| site_id | AC8 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE ADP F 1450 |
| Chain | Residue |
| F | ALA24 |
| F | HIS25 |
| F | HIS27 |
| F | GLY45 |
| F | VAL47 |
| F | GLY80 |
| F | THR81 |
| F | GLY82 |
| F | LYS83 |
| F | THR84 |
| F | ALA85 |
| F | TYR362 |
| F | ILE370 |
| F | LEU399 |
| F | ILE403 |
| site_id | AC9 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE ADP K 1450 |
| Chain | Residue |
| K | ALA24 |
| K | HIS25 |
| K | HIS27 |
| K | ILE28 |
| K | GLY45 |
| K | MET46 |
| K | VAL47 |
| K | THR81 |
| K | GLY82 |
| K | LYS83 |
| K | THR84 |
| K | ALA85 |
| K | TYR362 |
| K | ILE403 |
| site_id | BC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE ADP E 1450 |
| Chain | Residue |
| E | ALA24 |
| E | HIS25 |
| E | HIS27 |
| E | GLY45 |
| E | MET46 |
| E | VAL47 |
| E | GLY80 |
| E | THR81 |
| E | GLY82 |
| E | LYS83 |
| E | THR84 |
| E | ALA85 |
| E | TYR362 |
| E | ILE370 |
| E | LEU399 |
| E | ILE403 |
| site_id | BC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE ADP L 1450 |
| Chain | Residue |
| L | GLY80 |
| L | THR81 |
| L | GLY82 |
| L | LYS83 |
| L | THR84 |
| L | ALA85 |
| L | TYR362 |
| L | LEU399 |
| site_id | BC3 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE ADP G 1450 |
| Chain | Residue |
| G | ALA24 |
| G | HIS25 |
| G | HIS27 |
| G | GLY45 |
| G | MET46 |
| G | VAL47 |
| G | GLY80 |
| G | THR81 |
| G | GLY82 |
| G | LYS83 |
| G | THR84 |
| G | ALA85 |
| G | TYR362 |
| G | ILE370 |
| G | LEU399 |
| G | ILE403 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | GLY77 | |
| J | GLY77 | |
| K | GLY77 | |
| L | GLY77 | |
| B | GLY77 | |
| C | GLY77 | |
| D | GLY77 | |
| E | GLY77 | |
| F | GLY77 | |
| G | GLY77 | |
| H | GLY77 | |
| I | GLY77 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | MOD_RES: N-acetylalanine => ECO:0000269|Ref.14, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712 |
| Chain | Residue | Details |
| A | ALA2 | |
| J | ALA2 | |
| K | ALA2 | |
| L | ALA2 | |
| B | ALA2 | |
| C | ALA2 | |
| D | ALA2 | |
| E | ALA2 | |
| F | ALA2 | |
| G | ALA2 | |
| H | ALA2 | |
| I | ALA2 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER437 | |
| J | SER437 | |
| K | SER437 | |
| L | SER437 | |
| B | SER437 | |
| C | SER437 | |
| D | SER437 | |
| E | SER437 | |
| F | SER437 | |
| G | SER437 | |
| H | SER437 | |
| I | SER437 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 48 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | LYS9 | |
| C | LYS444 | |
| C | LYS456 | |
| D | LYS9 | |
| D | LYS444 | |
| D | LYS456 | |
| E | LYS9 | |
| E | LYS444 | |
| E | LYS456 | |
| F | LYS9 | |
| F | LYS444 | |
| F | LYS456 | |
| G | LYS9 | |
| G | LYS444 | |
| G | LYS456 | |
| H | LYS9 | |
| A | LYS444 | |
| H | LYS444 | |
| H | LYS456 | |
| I | LYS9 | |
| I | LYS444 | |
| I | LYS456 | |
| J | LYS9 | |
| J | LYS444 | |
| A | LYS456 | |
| J | LYS456 | |
| K | LYS9 | |
| K | LYS444 | |
| K | LYS456 | |
| L | LYS9 | |
| L | LYS444 | |
| L | LYS456 | |
| B | LYS9 | |
| B | LYS444 | |
| B | LYS456 | |
| C | LYS9 |
