3UEE

Crystal structure of human Survivin K62A mutant bound to N-terminal histone H3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000228	cellular_component	nuclear chromosome
A	0000278	biological_process	mitotic cell cycle
A	0000281	biological_process	mitotic cytokinesis
A	0000775	cellular_component	chromosome, centromeric region
A	0000776	cellular_component	kinetochore
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0005737	cellular_component	cytoplasm
A	0005819	cellular_component	spindle
A	0005829	cellular_component	cytosol
A	0007052	biological_process	mitotic spindle organization
A	0007059	biological_process	chromosome segregation
A	0007605	biological_process	sensory perception of sound
A	0008017	molecular_function	microtubule binding
A	0008284	biological_process	positive regulation of cell population proliferation
A	0015630	cellular_component	microtubule cytoskeleton
A	0019899	molecular_function	enzyme binding
A	0030496	cellular_component	midbody
A	0031267	molecular_function	small GTPase binding
A	0031503	biological_process	protein-containing complex localization
A	0032133	cellular_component	chromosome passenger complex
A	0042802	molecular_function	identical protein binding
A	0043066	biological_process	negative regulation of apoptotic process
A	0045171	cellular_component	intercellular bridge
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0051087	molecular_function	protein-folding chaperone binding
A	0051233	cellular_component	spindle midzone
A	0051256	biological_process	mitotic spindle midzone assembly
A	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
A	0090307	biological_process	mitotic spindle assembly
A	1901970	biological_process	positive regulation of mitotic sister chromatid separation
A	1902425	biological_process	positive regulation of attachment of mitotic spindle microtubules to kinetochore
A	1903490	biological_process	positive regulation of mitotic cytokinesis
C	0000228	cellular_component	nuclear chromosome
C	0000278	biological_process	mitotic cell cycle
C	0000281	biological_process	mitotic cytokinesis
C	0000775	cellular_component	chromosome, centromeric region
C	0000776	cellular_component	kinetochore
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005694	cellular_component	chromosome
C	0005737	cellular_component	cytoplasm
C	0005819	cellular_component	spindle
C	0005829	cellular_component	cytosol
C	0007052	biological_process	mitotic spindle organization
C	0007059	biological_process	chromosome segregation
C	0007605	biological_process	sensory perception of sound
C	0008017	molecular_function	microtubule binding
C	0008284	biological_process	positive regulation of cell population proliferation
C	0015630	cellular_component	microtubule cytoskeleton
C	0019899	molecular_function	enzyme binding
C	0030496	cellular_component	midbody
C	0031267	molecular_function	small GTPase binding
C	0031503	biological_process	protein-containing complex localization
C	0032133	cellular_component	chromosome passenger complex
C	0042802	molecular_function	identical protein binding
C	0043066	biological_process	negative regulation of apoptotic process
C	0045171	cellular_component	intercellular bridge
C	0045892	biological_process	negative regulation of DNA-templated transcription
C	0051087	molecular_function	protein-folding chaperone binding
C	0051233	cellular_component	spindle midzone
C	0051256	biological_process	mitotic spindle midzone assembly
C	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
C	0090307	biological_process	mitotic spindle assembly
C	1901970	biological_process	positive regulation of mitotic sister chromatid separation
C	1902425	biological_process	positive regulation of attachment of mitotic spindle microtubules to kinetochore
C	1903490	biological_process	positive regulation of mitotic cytokinesis

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 143

Chain	Residue
A	CYS57
A	CYS60
A	HIS77
A	CYS84

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 143

Chain	Residue
C	CYS57
C	CYS60
C	HIS77
C	CYS84

---

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR CHAIN B OF N-TERMINAL FRAGMENT OF HISTONE H3

Chain	Residue
A	GLU63
A	LEU64
A	GLU65
A	GLY66
A	TRP67
A	ASP71
A	GLU76
A	HIS80
B	HOH157
A	GLU51

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR CHAIN D OF N-TERMINAL FRAGMENT OF HISTONE H3

Chain	Residue
C	GLU63
C	LEU64
C	GLU65
C	GLY66
C	ASP71
C	GLU76
C	HIS80

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	140
Details	Repeat: {"description":"BIR"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17956729","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2QFA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Site: {"description":"Interaction with FBXL7","evidences":[{"source":"PubMed","id":"25778398","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by AURKC","evidences":[{"source":"PubMed","id":"27332895","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	14
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"20826784","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine; by CDK1 and CDK15","evidences":[{"source":"PubMed","id":"11069302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24866247","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine; by CK2; in vitro","evidences":[{"source":"PubMed","id":"21252625","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine; by AURKB","evidences":[{"source":"PubMed","id":"14610074","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"Citrulline; alternate","evidences":[{"source":"PubMed","id":"16567635","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine; by HASPIN and VRK1","evidences":[{"source":"PubMed","id":"15681610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16185088","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31527692","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"16267050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16457588","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17194708","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	Modified residue: {"description":"5-glutamyl serotonin; alternate","evidences":[{"source":"PubMed","id":"30867594","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---