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3UEE

Crystal structure of human Survivin K62A mutant bound to N-terminal histone H3

Functional Information from GO Data
ChainGOidnamespacecontents
A0000228cellular_componentnuclear chromosome
A0000278biological_processmitotic cell cycle
A0000281biological_processmitotic cytokinesis
A0000775cellular_componentchromosome, centromeric region
A0000776cellular_componentkinetochore
A0004869molecular_functioncysteine-type endopeptidase inhibitor activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005694cellular_componentchromosome
A0005737cellular_componentcytoplasm
A0005819cellular_componentspindle
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005874cellular_componentmicrotubule
A0006468biological_processprotein phosphorylation
A0006915biological_processapoptotic process
A0007052biological_processmitotic spindle organization
A0007059biological_processchromosome segregation
A0007605biological_processsensory perception of sound
A0008017molecular_functionmicrotubule binding
A0008284biological_processpositive regulation of cell population proliferation
A0015630cellular_componentmicrotubule cytoskeleton
A0019899molecular_functionenzyme binding
A0030496cellular_componentmidbody
A0031267molecular_functionsmall GTPase binding
A0031503biological_processprotein-containing complex localization
A0032133cellular_componentchromosome passenger complex
A0042802molecular_functionidentical protein binding
A0042981biological_processregulation of apoptotic process
A0043066biological_processnegative regulation of apoptotic process
A0045892biological_processnegative regulation of DNA-templated transcription
A0046872molecular_functionmetal ion binding
A0051087molecular_functionprotein-folding chaperone binding
A0051233cellular_componentspindle midzone
A0051256biological_processmitotic spindle midzone assembly
A0051301biological_processcell division
A0090267biological_processpositive regulation of mitotic cell cycle spindle assembly checkpoint
A0090307biological_processmitotic spindle assembly
A1901970biological_processpositive regulation of mitotic sister chromatid separation
A1902425biological_processpositive regulation of attachment of mitotic spindle microtubules to kinetochore
A1903490biological_processpositive regulation of mitotic cytokinesis
A1990713cellular_componentsurvivin complex
C0000228cellular_componentnuclear chromosome
C0000278biological_processmitotic cell cycle
C0000281biological_processmitotic cytokinesis
C0000775cellular_componentchromosome, centromeric region
C0000776cellular_componentkinetochore
C0004869molecular_functioncysteine-type endopeptidase inhibitor activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005694cellular_componentchromosome
C0005737cellular_componentcytoplasm
C0005819cellular_componentspindle
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005874cellular_componentmicrotubule
C0006468biological_processprotein phosphorylation
C0006915biological_processapoptotic process
C0007052biological_processmitotic spindle organization
C0007059biological_processchromosome segregation
C0007605biological_processsensory perception of sound
C0008017molecular_functionmicrotubule binding
C0008284biological_processpositive regulation of cell population proliferation
C0015630cellular_componentmicrotubule cytoskeleton
C0019899molecular_functionenzyme binding
C0030496cellular_componentmidbody
C0031267molecular_functionsmall GTPase binding
C0031503biological_processprotein-containing complex localization
C0032133cellular_componentchromosome passenger complex
C0042802molecular_functionidentical protein binding
C0042981biological_processregulation of apoptotic process
C0043066biological_processnegative regulation of apoptotic process
C0045892biological_processnegative regulation of DNA-templated transcription
C0046872molecular_functionmetal ion binding
C0051087molecular_functionprotein-folding chaperone binding
C0051233cellular_componentspindle midzone
C0051256biological_processmitotic spindle midzone assembly
C0051301biological_processcell division
C0090267biological_processpositive regulation of mitotic cell cycle spindle assembly checkpoint
C0090307biological_processmitotic spindle assembly
C1901970biological_processpositive regulation of mitotic sister chromatid separation
C1902425biological_processpositive regulation of attachment of mitotic spindle microtubules to kinetochore
C1903490biological_processpositive regulation of mitotic cytokinesis
C1990713cellular_componentsurvivin complex
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 143
ChainResidue
ACYS57
ACYS60
AHIS77
ACYS84

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN C 143
ChainResidue
CCYS57
CCYS60
CHIS77
CCYS84

site_idAC3
Number of Residues10
DetailsBINDING SITE FOR CHAIN B OF N-TERMINAL FRAGMENT OF HISTONE H3
ChainResidue
AGLU63
ALEU64
AGLU65
AGLY66
ATRP67
AASP71
AGLU76
AHIS80
BHOH157
AGLU51

site_idAC4
Number of Residues7
DetailsBINDING SITE FOR CHAIN D OF N-TERMINAL FRAGMENT OF HISTONE H3
ChainResidue
CGLU63
CLEU64
CGLU65
CGLY66
CASP71
CGLU76
CHIS80

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: Citrulline; alternate => ECO:0000269|PubMed:16567635
ChainResidueDetails
BARG2
DARG2
AHIS77
ACYS84
CCYS57
CCYS60
CHIS77
CCYS84

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by HASPIN and VRK1 => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:31527692
ChainResidueDetails
BTHR3
DTHR3

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708
ChainResidueDetails
BLYS4
DLYS4

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: 5-glutamyl serotonin; alternate => ECO:0000269|PubMed:30867594
ChainResidueDetails
BGLN5
CLYS110
CLYS112
CLYS115
CLYS121
CLYS129
DGLN5
ALYS110
ALYS112
ALYS115
ALYS121
ALYS129
CLYS23
CLYS90

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by PKC => ECO:0000269|PubMed:20228790
ChainResidueDetails
BTHR6
DTHR6

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Symmetric dimethylarginine; by PRMT5; alternate => ECO:0000250|UniProtKB:P68433
ChainResidueDetails
BARG8
DARG8

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:11242053, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708
ChainResidueDetails
BLYS9
DLYS9

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: Phosphoserine; alternate; by AURKB, AURKC, RPS6KA3, RPS6KA4 and RPS6KA5 => ECO:0000269|PubMed:10464286, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:12560483, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16457588
ChainResidueDetails
BSER10
DSER10

site_idSWS_FT_FI9
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by PKC and CHEK1 => ECO:0000269|PubMed:12560483, ECO:0000269|PubMed:18066052, ECO:0000269|PubMed:18243098, ECO:0000269|PubMed:22901803
ChainResidueDetails
BTHR11
DTHR11

227111

PDB entries from 2024-11-06

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