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3U6F

Mouse TREX1 D200N mutant

Functional Information from GO Data
ChainGOidnamespacecontents
A0000077biological_processDNA damage checkpoint signaling
A0000287molecular_functionmagnesium ion binding
A0001568biological_processblood vessel development
A0001822biological_processkidney development
A0002250biological_processadaptive immune response
A0002251biological_processorgan or tissue specific immune response
A0002253biological_processactivation of immune response
A0002281biological_processmacrophage activation involved in immune response
A0002320biological_processlymphoid progenitor cell differentiation
A0002383biological_processimmune response in brain or nervous system
A0002437biological_processinflammatory response to antigenic stimulus
A0002457biological_processT cell antigen processing and presentation
A0002637biological_processregulation of immunoglobulin production
A0003007biological_processheart morphogenesis
A0003015biological_processheart process
A0003228biological_processatrial cardiac muscle tissue development
A0003676molecular_functionnucleic acid binding
A0003677molecular_functionDNA binding
A0003690molecular_functiondouble-stranded DNA binding
A0003697molecular_functionsingle-stranded DNA binding
A0004527molecular_functionexonuclease activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005829cellular_componentcytosol
A0006091biological_processgeneration of precursor metabolites and energy
A0006110biological_processregulation of glycolytic process
A0006259biological_processDNA metabolic process
A0006260biological_processDNA replication
A0006304biological_processDNA modification
A0006308biological_processDNA catabolic process
A0006954biological_processinflammatory response
A0006955biological_processimmune response
A0006974biological_processDNA damage response
A0008250cellular_componentoligosaccharyltransferase complex
A0008296molecular_function3'-5'-DNA exonuclease activity
A0008301molecular_functionDNA binding, bending
A0008311molecular_functiondouble-stranded DNA 3'-5' DNA exonuclease activity
A0008340biological_processdetermination of adult lifespan
A0008408molecular_function3'-5' exonuclease activity
A0009411biological_processresponse to UV
A0010468biological_processregulation of gene expression
A0016020cellular_componentmembrane
A0019217biological_processregulation of fatty acid metabolic process
A0031571biological_processmitotic G1 DNA damage checkpoint signaling
A0032197biological_processretrotransposition
A0032405molecular_functionMutLalpha complex binding
A0032407molecular_functionMutSalpha complex binding
A0032479biological_processregulation of type I interferon production
A0032508biological_processDNA duplex unwinding
A0032558molecular_functionadenyl deoxyribonucleotide binding
A0032680biological_processregulation of tumor necrosis factor production
A0032993cellular_componentprotein-DNA complex
A0034599biological_processcellular response to oxidative stress
A0034614biological_processcellular response to reactive oxygen species
A0034644biological_processcellular response to UV
A0035458biological_processcellular response to interferon-beta
A0035781biological_processCD86 biosynthetic process
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0043277biological_processapoptotic cell clearance
A0043457biological_processregulation of cellular respiration
A0043596cellular_componentnuclear replication fork
A0045087biological_processinnate immune response
A0045088biological_processregulation of innate immune response
A0045184biological_processestablishment of protein localization
A0045824biological_processnegative regulation of innate immune response
A0046872molecular_functionmetal ion binding
A0046890biological_processregulation of lipid biosynthetic process
A0050699molecular_functionWW domain binding
A0050727biological_processregulation of inflammatory response
A0050821biological_processprotein stabilization
A0050863biological_processregulation of T cell activation
A0051607biological_processdefense response to virus
A0060337biological_processtype I interferon-mediated signaling pathway
A0060339biological_processnegative regulation of type I interferon-mediated signaling pathway
A0061635biological_processregulation of protein complex stability
A0071310biological_processobsolete cellular response to organic substance
A0071357biological_processcellular response to type I interferon
A0071480biological_processcellular response to gamma radiation
A0072711biological_processcellular response to hydroxyurea
A0097281biological_processimmune complex formation
A0160049biological_processnegative regulation of cGAS/STING signaling pathway
A1904161biological_processDNA synthesis involved in UV-damage excision repair
A1905671biological_processregulation of lysosome organization
B0000077biological_processDNA damage checkpoint signaling
B0000287molecular_functionmagnesium ion binding
B0001568biological_processblood vessel development
B0001822biological_processkidney development
B0002250biological_processadaptive immune response
B0002251biological_processorgan or tissue specific immune response
B0002253biological_processactivation of immune response
B0002281biological_processmacrophage activation involved in immune response
B0002320biological_processlymphoid progenitor cell differentiation
B0002383biological_processimmune response in brain or nervous system
B0002437biological_processinflammatory response to antigenic stimulus
B0002457biological_processT cell antigen processing and presentation
B0002637biological_processregulation of immunoglobulin production
B0003007biological_processheart morphogenesis
B0003015biological_processheart process
B0003228biological_processatrial cardiac muscle tissue development
B0003676molecular_functionnucleic acid binding
B0003677molecular_functionDNA binding
B0003690molecular_functiondouble-stranded DNA binding
B0003697molecular_functionsingle-stranded DNA binding
B0004527molecular_functionexonuclease activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005829cellular_componentcytosol
B0006091biological_processgeneration of precursor metabolites and energy
B0006110biological_processregulation of glycolytic process
B0006259biological_processDNA metabolic process
B0006260biological_processDNA replication
B0006304biological_processDNA modification
B0006308biological_processDNA catabolic process
B0006954biological_processinflammatory response
B0006955biological_processimmune response
B0006974biological_processDNA damage response
B0008250cellular_componentoligosaccharyltransferase complex
B0008296molecular_function3'-5'-DNA exonuclease activity
B0008301molecular_functionDNA binding, bending
B0008311molecular_functiondouble-stranded DNA 3'-5' DNA exonuclease activity
B0008340biological_processdetermination of adult lifespan
B0008408molecular_function3'-5' exonuclease activity
B0009411biological_processresponse to UV
B0010468biological_processregulation of gene expression
B0016020cellular_componentmembrane
B0019217biological_processregulation of fatty acid metabolic process
B0031571biological_processmitotic G1 DNA damage checkpoint signaling
B0032197biological_processretrotransposition
B0032405molecular_functionMutLalpha complex binding
B0032407molecular_functionMutSalpha complex binding
B0032479biological_processregulation of type I interferon production
B0032508biological_processDNA duplex unwinding
B0032558molecular_functionadenyl deoxyribonucleotide binding
B0032680biological_processregulation of tumor necrosis factor production
B0032993cellular_componentprotein-DNA complex
B0034599biological_processcellular response to oxidative stress
B0034614biological_processcellular response to reactive oxygen species
B0034644biological_processcellular response to UV
B0035458biological_processcellular response to interferon-beta
B0035781biological_processCD86 biosynthetic process
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0043277biological_processapoptotic cell clearance
B0043457biological_processregulation of cellular respiration
B0043596cellular_componentnuclear replication fork
B0045087biological_processinnate immune response
B0045088biological_processregulation of innate immune response
B0045184biological_processestablishment of protein localization
B0045824biological_processnegative regulation of innate immune response
B0046872molecular_functionmetal ion binding
B0046890biological_processregulation of lipid biosynthetic process
B0050699molecular_functionWW domain binding
B0050727biological_processregulation of inflammatory response
B0050821biological_processprotein stabilization
B0050863biological_processregulation of T cell activation
B0051607biological_processdefense response to virus
B0060337biological_processtype I interferon-mediated signaling pathway
B0060339biological_processnegative regulation of type I interferon-mediated signaling pathway
B0061635biological_processregulation of protein complex stability
B0071310biological_processobsolete cellular response to organic substance
B0071357biological_processcellular response to type I interferon
B0071480biological_processcellular response to gamma radiation
B0072711biological_processcellular response to hydroxyurea
B0097281biological_processimmune complex formation
B0160049biological_processnegative regulation of cGAS/STING signaling pathway
B1904161biological_processDNA synthesis involved in UV-damage excision repair
B1905671biological_processregulation of lysosome organization
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE BU1 B 315
ChainResidue
BTHR192
BASP193
BGLU198
BGLY199
BLEU202

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE BU1 A 315
ChainResidue
AASP193
ATHR196
AGLU198
AHOH360

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG C 5
ChainResidue
BASP18
BHOH332
BHOH363
BHOH370
CDC3
CDG4

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG D 5
ChainResidue
AASP18
AHOH331
AHOH359
AHOH381
DDC3
DDG4

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton donor/acceptor => ECO:0000269|PubMed:17355961
ChainResidueDetails
BHIS195
AHIS195

site_idSWS_FT_FI2
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:17293595, ECO:0000269|PubMed:17355961, ECO:0000269|PubMed:18780819, ECO:0000269|PubMed:22071149
ChainResidueDetails
BASP18
BGLU20
BTYR129
BASN200
AASP18
AGLU20
ATYR129
AASN200

site_idSWS_FT_FI3
Number of Residues6
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9NSU2
ChainResidueDetails
BSER78
BSER167
BSER261
ASER78
ASER167
ASER261

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PDB entries from 2024-07-17

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