Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3U60

Structure of T4 Bacteriophage Clamp Loader Bound To Open Clamp, DNA and ATP Analog

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003689	molecular_function	DNA clamp loader activity
A	0006260	biological_process	DNA replication
A	0039686	biological_process	bidirectional double-stranded viral DNA replication
A	0039693	biological_process	viral DNA genome replication
B	0000166	molecular_function	nucleotide binding
B	0003677	molecular_function	DNA binding
B	0003689	molecular_function	DNA clamp loader activity
B	0005524	molecular_function	ATP binding
B	0006260	biological_process	DNA replication
B	0006261	biological_process	DNA-templated DNA replication
B	0006281	biological_process	DNA repair
B	0016787	molecular_function	hydrolase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0039686	biological_process	bidirectional double-stranded viral DNA replication
B	0039693	biological_process	viral DNA genome replication
C	0000166	molecular_function	nucleotide binding
C	0003677	molecular_function	DNA binding
C	0003689	molecular_function	DNA clamp loader activity
C	0005524	molecular_function	ATP binding
C	0006260	biological_process	DNA replication
C	0006261	biological_process	DNA-templated DNA replication
C	0006281	biological_process	DNA repair
C	0016787	molecular_function	hydrolase activity
C	0016887	molecular_function	ATP hydrolysis activity
C	0039686	biological_process	bidirectional double-stranded viral DNA replication
C	0039693	biological_process	viral DNA genome replication
D	0000166	molecular_function	nucleotide binding
D	0003677	molecular_function	DNA binding
D	0003689	molecular_function	DNA clamp loader activity
D	0005524	molecular_function	ATP binding
D	0006260	biological_process	DNA replication
D	0006261	biological_process	DNA-templated DNA replication
D	0006281	biological_process	DNA repair
D	0016787	molecular_function	hydrolase activity
D	0016887	molecular_function	ATP hydrolysis activity
D	0039686	biological_process	bidirectional double-stranded viral DNA replication
D	0039693	biological_process	viral DNA genome replication
E	0000166	molecular_function	nucleotide binding
E	0003677	molecular_function	DNA binding
E	0003689	molecular_function	DNA clamp loader activity
E	0005524	molecular_function	ATP binding
E	0006260	biological_process	DNA replication
E	0006261	biological_process	DNA-templated DNA replication
E	0006281	biological_process	DNA repair
E	0016787	molecular_function	hydrolase activity
E	0016887	molecular_function	ATP hydrolysis activity
E	0039686	biological_process	bidirectional double-stranded viral DNA replication
E	0039693	biological_process	viral DNA genome replication
F	0006260	biological_process	DNA replication
F	0019083	biological_process	viral transcription
F	0030337	molecular_function	DNA polymerase processivity factor activity
F	0039686	biological_process	bidirectional double-stranded viral DNA replication
F	0039693	biological_process	viral DNA genome replication
G	0006260	biological_process	DNA replication
G	0019083	biological_process	viral transcription
G	0030337	molecular_function	DNA polymerase processivity factor activity
G	0039686	biological_process	bidirectional double-stranded viral DNA replication
G	0039693	biological_process	viral DNA genome replication
H	0006260	biological_process	DNA replication
H	0019083	biological_process	viral transcription
H	0030337	molecular_function	DNA polymerase processivity factor activity
H	0039686	biological_process	bidirectional double-stranded viral DNA replication
H	0039693	biological_process	viral DNA genome replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE 08T B 700

Chain	Residue
B	GLU12
B	THR57
B	THR58
B	GLU108
B	ASN139
B	PHE204
B	ARG205
B	MG800
C	GLU126
C	ARG151
B	ARG16
B	ILE24
B	LEU25
B	PRO52
B	GLY53
B	THR54
B	GLY55
B	LYS56

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 800

Chain	Residue
B	THR57
B	ASP107
B	GLU108
B	08T700
C	GLU126
C	ARG151

site_id	AC3
Number of Residues	18
Details	BINDING SITE FOR RESIDUE 08T C 700

Chain	Residue
C	GLU12
C	ARG16
C	ILE24
C	PRO52
C	GLY53
C	THR54
C	GLY55
C	LYS56
C	THR57
C	THR58
C	GLU108
C	ASN139
C	PHE204
C	ARG205
C	ILE208
C	MG800
D	GLU126
D	ARG151

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG C 800

Chain	Residue
C	THR57
C	ASP107
C	GLU108
C	08T700
D	GLU126
D	ARG151

site_id	AC5
Number of Residues	19
Details	BINDING SITE FOR RESIDUE 08T D 700

Chain	Residue
D	GLU12
D	TYR15
D	ARG16
D	PRO17
D	ILE24
D	PRO52
D	GLY53
D	THR54
D	GLY55
D	LYS56
D	THR57
D	THR58
D	GLU108
D	ASN139
D	PHE204
D	ARG205
D	MG800
E	GLU126
E	ARG151

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG D 800

Chain	Residue
D	THR57
D	ASP107
D	GLU108
D	08T700
E	GLU126
E	ARG151

site_id	AC7
Number of Residues	13
Details	BINDING SITE FOR RESIDUE ADP E 700

Chain	Residue
E	GLU12
E	PRO17
E	ILE24
E	PRO52
E	GLY53
E	THR54
E	GLY55
E	LYS56
E	THR57
E	THR58
E	ARG205
E	ILE208
E	MG801

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG E 801

Chain	Residue
E	THR57
E	ASP107
E	GLU108
E	ARG205
E	ADP700

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_04162","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"22194570","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)