Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3U5Z

Structure of T4 Bacteriophage clamp loader bound to the T4 clamp, primer-template DNA, and ATP analog

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003689	molecular_function	DNA clamp loader activity
A	0006260	biological_process	DNA replication
A	0039686	biological_process	bidirectional double-stranded viral DNA replication
A	0039693	biological_process	viral DNA genome replication
B	0003677	molecular_function	DNA binding
B	0003689	molecular_function	DNA clamp loader activity
B	0005524	molecular_function	ATP binding
B	0005663	cellular_component	DNA replication factor C complex
B	0006260	biological_process	DNA replication
B	0006261	biological_process	DNA-templated DNA replication
B	0006281	biological_process	DNA repair
B	0016787	molecular_function	hydrolase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0039686	biological_process	bidirectional double-stranded viral DNA replication
B	0039693	biological_process	viral DNA genome replication
C	0003677	molecular_function	DNA binding
C	0003689	molecular_function	DNA clamp loader activity
C	0005524	molecular_function	ATP binding
C	0005663	cellular_component	DNA replication factor C complex
C	0006260	biological_process	DNA replication
C	0006261	biological_process	DNA-templated DNA replication
C	0006281	biological_process	DNA repair
C	0016787	molecular_function	hydrolase activity
C	0016887	molecular_function	ATP hydrolysis activity
C	0039686	biological_process	bidirectional double-stranded viral DNA replication
C	0039693	biological_process	viral DNA genome replication
D	0003677	molecular_function	DNA binding
D	0003689	molecular_function	DNA clamp loader activity
D	0005524	molecular_function	ATP binding
D	0005663	cellular_component	DNA replication factor C complex
D	0006260	biological_process	DNA replication
D	0006261	biological_process	DNA-templated DNA replication
D	0006281	biological_process	DNA repair
D	0016787	molecular_function	hydrolase activity
D	0016887	molecular_function	ATP hydrolysis activity
D	0039686	biological_process	bidirectional double-stranded viral DNA replication
D	0039693	biological_process	viral DNA genome replication
E	0003677	molecular_function	DNA binding
E	0003689	molecular_function	DNA clamp loader activity
E	0005524	molecular_function	ATP binding
E	0005663	cellular_component	DNA replication factor C complex
E	0006260	biological_process	DNA replication
E	0006261	biological_process	DNA-templated DNA replication
E	0006281	biological_process	DNA repair
E	0016787	molecular_function	hydrolase activity
E	0016887	molecular_function	ATP hydrolysis activity
E	0039686	biological_process	bidirectional double-stranded viral DNA replication
E	0039693	biological_process	viral DNA genome replication
F	0006260	biological_process	DNA replication
F	0019083	biological_process	viral transcription
F	0030337	molecular_function	DNA polymerase processivity factor activity
F	0039686	biological_process	bidirectional double-stranded viral DNA replication
F	0039693	biological_process	viral DNA genome replication
G	0006260	biological_process	DNA replication
G	0019083	biological_process	viral transcription
G	0030337	molecular_function	DNA polymerase processivity factor activity
G	0039686	biological_process	bidirectional double-stranded viral DNA replication
G	0039693	biological_process	viral DNA genome replication
H	0006260	biological_process	DNA replication
H	0019083	biological_process	viral transcription
H	0030337	molecular_function	DNA polymerase processivity factor activity
H	0039686	biological_process	bidirectional double-stranded viral DNA replication
H	0039693	biological_process	viral DNA genome replication
K	0003677	molecular_function	DNA binding
K	0003689	molecular_function	DNA clamp loader activity
K	0006260	biological_process	DNA replication
K	0039686	biological_process	bidirectional double-stranded viral DNA replication
K	0039693	biological_process	viral DNA genome replication
L	0003677	molecular_function	DNA binding
L	0003689	molecular_function	DNA clamp loader activity
L	0005524	molecular_function	ATP binding
L	0005663	cellular_component	DNA replication factor C complex
L	0006260	biological_process	DNA replication
L	0006261	biological_process	DNA-templated DNA replication
L	0006281	biological_process	DNA repair
L	0016787	molecular_function	hydrolase activity
L	0016887	molecular_function	ATP hydrolysis activity
L	0039686	biological_process	bidirectional double-stranded viral DNA replication
L	0039693	biological_process	viral DNA genome replication
M	0003677	molecular_function	DNA binding
M	0003689	molecular_function	DNA clamp loader activity
M	0005524	molecular_function	ATP binding
M	0005663	cellular_component	DNA replication factor C complex
M	0006260	biological_process	DNA replication
M	0006261	biological_process	DNA-templated DNA replication
M	0006281	biological_process	DNA repair
M	0016787	molecular_function	hydrolase activity
M	0016887	molecular_function	ATP hydrolysis activity
M	0039686	biological_process	bidirectional double-stranded viral DNA replication
M	0039693	biological_process	viral DNA genome replication
N	0003677	molecular_function	DNA binding
N	0003689	molecular_function	DNA clamp loader activity
N	0005524	molecular_function	ATP binding
N	0005663	cellular_component	DNA replication factor C complex
N	0006260	biological_process	DNA replication
N	0006261	biological_process	DNA-templated DNA replication
N	0006281	biological_process	DNA repair
N	0016787	molecular_function	hydrolase activity
N	0016887	molecular_function	ATP hydrolysis activity
N	0039686	biological_process	bidirectional double-stranded viral DNA replication
N	0039693	biological_process	viral DNA genome replication
O	0003677	molecular_function	DNA binding
O	0003689	molecular_function	DNA clamp loader activity
O	0005524	molecular_function	ATP binding
O	0005663	cellular_component	DNA replication factor C complex
O	0006260	biological_process	DNA replication
O	0006261	biological_process	DNA-templated DNA replication
O	0006281	biological_process	DNA repair
O	0016787	molecular_function	hydrolase activity
O	0016887	molecular_function	ATP hydrolysis activity
O	0039686	biological_process	bidirectional double-stranded viral DNA replication
O	0039693	biological_process	viral DNA genome replication
P	0006260	biological_process	DNA replication
P	0019083	biological_process	viral transcription
P	0030337	molecular_function	DNA polymerase processivity factor activity
P	0039686	biological_process	bidirectional double-stranded viral DNA replication
P	0039693	biological_process	viral DNA genome replication
Q	0006260	biological_process	DNA replication
Q	0019083	biological_process	viral transcription
Q	0030337	molecular_function	DNA polymerase processivity factor activity
Q	0039686	biological_process	bidirectional double-stranded viral DNA replication
Q	0039693	biological_process	viral DNA genome replication
R	0006260	biological_process	DNA replication
R	0019083	biological_process	viral transcription
R	0030337	molecular_function	DNA polymerase processivity factor activity
R	0039686	biological_process	bidirectional double-stranded viral DNA replication
R	0039693	biological_process	viral DNA genome replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE 08T B 700

Chain	Residue
B	GLU12
B	THR58
B	GLU108
B	ASN139
B	PHE204
B	ARG205
B	MG800
C	GLU126
C	ARG151
B	ARG16
B	ILE24
B	PRO52
B	GLY53
B	THR54
B	GLY55
B	LYS56
B	THR57

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 800

Chain	Residue
B	THR57
B	ASP107
B	GLU108
B	08T700
C	GLU126
C	ARG151

site_id	AC3
Number of Residues	20
Details	BINDING SITE FOR RESIDUE 08T C 700

Chain	Residue
C	GLU12
C	TYR15
C	ARG16
C	PRO17
C	ILE24
C	PRO52
C	GLY53
C	THR54
C	GLY55
C	LYS56
C	THR57
C	THR58
C	GLU108
C	ASN139
C	PHE204
C	ARG205
C	ILE208
C	MG800
D	GLU126
D	ARG151

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG C 800

Chain	Residue
C	THR57
C	ASP107
C	GLU108
C	08T700
D	GLU126
D	ARG151

site_id	AC5
Number of Residues	20
Details	BINDING SITE FOR RESIDUE 08T D 700

Chain	Residue
D	GLU12
D	TYR15
D	ARG16
D	PRO17
D	ILE24
D	PRO52
D	GLY53
D	THR54
D	GLY55
D	LYS56
D	THR57
D	THR58
D	GLU108
D	ASN139
D	PHE204
D	ARG205
D	ILE208
D	MG800
E	GLU126
E	ARG151

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG D 800

Chain	Residue
D	THR57
D	ASP107
D	GLU108
D	08T700
E	GLU126
E	ARG151

site_id	AC7
Number of Residues	13
Details	BINDING SITE FOR RESIDUE ADP E 700

Chain	Residue
E	GLU12
E	ARG16
E	ILE24
E	GLY53
E	THR54
E	GLY55
E	LYS56
E	THR57
E	THR58
E	PHE204
E	ARG205
E	ILE208
E	MG801

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG E 801

Chain	Residue
E	THR57
E	ASP107
E	ARG205
E	ADP700

site_id	AC9
Number of Residues	18
Details	BINDING SITE FOR RESIDUE 08T L 700

Chain	Residue
L	GLY55
L	LYS56
L	THR57
L	THR58
L	GLU108
L	ASN139
L	PHE204
L	ARG205
L	MG800
M	GLU126
M	ARG151
L	GLU12
L	ARG16
L	PRO17
L	ILE24
L	PRO52
L	GLY53
L	THR54

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG L 800

Chain	Residue
L	THR57
L	GLU108
L	ARG205
L	08T700
M	GLU126
M	ARG151

site_id	BC2
Number of Residues	19
Details	BINDING SITE FOR RESIDUE 08T M 700

Chain	Residue
M	GLU12
M	TYR15
M	ARG16
M	ILE24
M	PRO52
M	GLY53
M	THR54
M	GLY55
M	LYS56
M	THR57
M	THR58
M	GLU108
M	ASN139
M	PHE204
M	ARG205
M	ILE208
M	MG800
N	GLU126
N	ARG151

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG M 800

Chain	Residue
M	THR57
M	ASP107
M	GLU108
M	08T700
N	GLU126
N	ARG151

site_id	BC4
Number of Residues	18
Details	BINDING SITE FOR RESIDUE 08T N 700

Chain	Residue
N	GLU12
N	ARG16
N	PRO17
N	ILE24
N	GLY53
N	THR54
N	GLY55
N	LYS56
N	THR57
N	THR58
N	GLU108
N	ASN139
N	PHE204
N	ARG205
N	ILE208
N	MG800
O	GLU126
O	ARG151

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG N 800

Chain	Residue
N	THR57
N	ASP107
N	GLU108
N	08T700
O	GLU126
O	ARG151

site_id	BC6
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ADP O 700

Chain	Residue
O	GLU12
O	ARG16
O	PRO17
O	CYS23
O	ILE24
O	GLY53
O	THR54
O	GLY55
O	LYS56
O	THR57
O	THR58
O	PHE204
O	ARG205
O	ILE208
O	MG801

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG O 801

Chain	Residue
O	THR57
O	ASP107
O	GLU108
O	ADP700

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_04162, ECO:0000269\|PubMed:22194570

Chain	Residue	Details
B	GLU12
D	ILE24
D	GLY53
D	ARG205
E	GLU12
E	ILE24
E	GLY53
E	ARG205
L	GLU12
L	ILE24
L	GLY53
B	ILE24
L	ARG205
M	GLU12
M	ILE24
M	GLY53
M	ARG205
N	GLU12
N	ILE24
N	GLY53
N	ARG205
O	GLU12
B	GLY53
O	ILE24
O	GLY53
O	ARG205
B	ARG205
C	GLU12
C	ILE24
C	GLY53
C	ARG205
D	GLU12

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)