3U53
Crystal structure of human Ap4A hydrolase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004081 | molecular_function | bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| A | 0006167 | biological_process | AMP biosynthetic process |
| A | 0006754 | biological_process | ATP biosynthetic process |
| A | 0006915 | biological_process | apoptotic process |
| A | 0008796 | molecular_function | bis(5'-nucleosyl)-tetraphosphatase activity |
| A | 0008803 | molecular_function | bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0034599 | biological_process | cellular response to oxidative stress |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004081 | molecular_function | bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005525 | molecular_function | GTP binding |
| B | 0005759 | cellular_component | mitochondrial matrix |
| B | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| B | 0006167 | biological_process | AMP biosynthetic process |
| B | 0006754 | biological_process | ATP biosynthetic process |
| B | 0006915 | biological_process | apoptotic process |
| B | 0008796 | molecular_function | bis(5'-nucleosyl)-tetraphosphatase activity |
| B | 0008803 | molecular_function | bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0034599 | biological_process | cellular response to oxidative stress |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0004081 | molecular_function | bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005525 | molecular_function | GTP binding |
| C | 0005759 | cellular_component | mitochondrial matrix |
| C | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| C | 0006167 | biological_process | AMP biosynthetic process |
| C | 0006754 | biological_process | ATP biosynthetic process |
| C | 0006915 | biological_process | apoptotic process |
| C | 0008796 | molecular_function | bis(5'-nucleosyl)-tetraphosphatase activity |
| C | 0008803 | molecular_function | bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0034599 | biological_process | cellular response to oxidative stress |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0004081 | molecular_function | bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005525 | molecular_function | GTP binding |
| D | 0005759 | cellular_component | mitochondrial matrix |
| D | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| D | 0006167 | biological_process | AMP biosynthetic process |
| D | 0006754 | biological_process | ATP biosynthetic process |
| D | 0006915 | biological_process | apoptotic process |
| D | 0008796 | molecular_function | bis(5'-nucleosyl)-tetraphosphatase activity |
| D | 0008803 | molecular_function | bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0034599 | biological_process | cellular response to oxidative stress |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 156 |
| Chain | Residue |
| A | ASN22 |
| A | ALA23 |
| A | ILE24 |
| A | HIS139 |
| A | HOH175 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 157 |
| Chain | Residue |
| A | HIS37 |
| A | LYS42 |
| A | TYR82 |
| A | ALA84 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE SO4 A 158 |
| Chain | Residue |
| A | HIS109 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 159 |
| Chain | Residue |
| A | ARG12 |
| A | ARG13 |
| A | VAL98 |
| A | LYS99 |
| A | TYR101 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 156 |
| Chain | Residue |
| B | ASN22 |
| B | ALA23 |
| B | ILE24 |
| B | HIS139 |
| B | HOH174 |
| B | HOH190 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 157 |
| Chain | Residue |
| B | LEU70 |
| B | THR71 |
| B | ILE72 |
| C | LEU70 |
| C | ILE72 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 158 |
| Chain | Residue |
| B | HIS44 |
| B | GLU58 |
| B | GLU110 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 159 |
| Chain | Residue |
| B | HIS37 |
| B | LYS42 |
| B | TYR82 |
| B | ALA84 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 156 |
| Chain | Residue |
| A | ARG12 |
| C | TYR114 |
| C | TRP116 |
| C | HOH173 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C 157 |
| Chain | Residue |
| C | ASN22 |
| C | ALA23 |
| C | ILE24 |
| C | HIS139 |
| C | HOH176 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C 158 |
| Chain | Residue |
| C | ASP100 |
| C | TYR101 |
| C | ASP102 |
| C | SO4160 |
| C | HOH178 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 C 159 |
| Chain | Residue |
| C | HIS37 |
| C | TYR82 |
| C | ALA84 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 C 160 |
| Chain | Residue |
| C | ARG12 |
| C | ARG13 |
| C | GLU97 |
| C | VAL98 |
| C | LYS99 |
| C | SO4158 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 D 156 |
| Chain | Residue |
| B | ARG12 |
| B | TRP116 |
| D | TYR114 |
| D | TRP116 |
| D | HOH177 |
| D | HOH182 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D 157 |
| Chain | Residue |
| D | ASN22 |
| D | ALA23 |
| D | ILE24 |
| D | HIS139 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 D 158 |
| Chain | Residue |
| A | LEU70 |
| A | THR71 |
| A | ILE72 |
| D | LEU70 |
| D | THR71 |
| D | ILE72 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D 159 |
| Chain | Residue |
| B | ARG115 |
| D | ASP100 |
| D | TYR101 |
| D | ASP102 |
| site_id | BC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 D 160 |
| Chain | Residue |
| D | LYS42 |
| D | TYR82 |
| D | ALA84 |
Functional Information from PROSITE/UniProt
| site_id | PS00893 |
| Number of Residues | 22 |
| Details | NUDIX_BOX Nudix box signature. GhvepgEddleTAlRETqEEaG |
| Chain | Residue | Details |
| A | GLY43-GLY64 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | MOD_RES: N-acetylalanine => ECO:0000269|Ref.5 |
| Chain | Residue | Details |
| A | ALA2 | |
| B | ALA2 | |
| C | ALA2 | |
| D | ALA2 |
