Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3U53

Crystal structure of human Ap4A hydrolase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004081	molecular_function	bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005759	cellular_component	mitochondrial matrix
A	0006139	biological_process	nucleobase-containing compound metabolic process
A	0006167	biological_process	AMP biosynthetic process
A	0006754	biological_process	ATP biosynthetic process
A	0006915	biological_process	apoptotic process
A	0008796	molecular_function	bis(5'-nucleosyl)-tetraphosphatase activity
A	0008803	molecular_function	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity
A	0016787	molecular_function	hydrolase activity
A	0034599	biological_process	cellular response to oxidative stress
B	0000166	molecular_function	nucleotide binding
B	0004081	molecular_function	bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005759	cellular_component	mitochondrial matrix
B	0006139	biological_process	nucleobase-containing compound metabolic process
B	0006167	biological_process	AMP biosynthetic process
B	0006754	biological_process	ATP biosynthetic process
B	0006915	biological_process	apoptotic process
B	0008796	molecular_function	bis(5'-nucleosyl)-tetraphosphatase activity
B	0008803	molecular_function	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity
B	0016787	molecular_function	hydrolase activity
B	0034599	biological_process	cellular response to oxidative stress
C	0000166	molecular_function	nucleotide binding
C	0004081	molecular_function	bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005759	cellular_component	mitochondrial matrix
C	0006139	biological_process	nucleobase-containing compound metabolic process
C	0006167	biological_process	AMP biosynthetic process
C	0006754	biological_process	ATP biosynthetic process
C	0006915	biological_process	apoptotic process
C	0008796	molecular_function	bis(5'-nucleosyl)-tetraphosphatase activity
C	0008803	molecular_function	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity
C	0016787	molecular_function	hydrolase activity
C	0034599	biological_process	cellular response to oxidative stress
D	0000166	molecular_function	nucleotide binding
D	0004081	molecular_function	bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity
D	0005515	molecular_function	protein binding
D	0005525	molecular_function	GTP binding
D	0005759	cellular_component	mitochondrial matrix
D	0006139	biological_process	nucleobase-containing compound metabolic process
D	0006167	biological_process	AMP biosynthetic process
D	0006754	biological_process	ATP biosynthetic process
D	0006915	biological_process	apoptotic process
D	0008796	molecular_function	bis(5'-nucleosyl)-tetraphosphatase activity
D	0008803	molecular_function	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity
D	0016787	molecular_function	hydrolase activity
D	0034599	biological_process	cellular response to oxidative stress

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 156

Chain	Residue
A	ASN22
A	ALA23
A	ILE24
A	HIS139
A	HOH175

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 157

Chain	Residue
A	HIS37
A	LYS42
A	TYR82
A	ALA84

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 A 158

Chain	Residue
A	HIS109

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 159

Chain	Residue
A	ARG12
A	ARG13
A	VAL98
A	LYS99
A	TYR101

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 156

Chain	Residue
B	ASN22
B	ALA23
B	ILE24
B	HIS139
B	HOH174
B	HOH190

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 157

Chain	Residue
B	LEU70
B	THR71
B	ILE72
C	LEU70
C	ILE72

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 158

Chain	Residue
B	HIS44
B	GLU58
B	GLU110

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 159

Chain	Residue
B	HIS37
B	LYS42
B	TYR82
B	ALA84

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 156

Chain	Residue
A	ARG12
C	TYR114
C	TRP116
C	HOH173

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C 157

Chain	Residue
C	ASN22
C	ALA23
C	ILE24
C	HIS139
C	HOH176

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C 158

Chain	Residue
C	ASP100
C	TYR101
C	ASP102
C	SO4160
C	HOH178

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 159

Chain	Residue
C	HIS37
C	TYR82
C	ALA84

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 C 160

Chain	Residue
C	ARG12
C	ARG13
C	GLU97
C	VAL98
C	LYS99
C	SO4158

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 D 156

Chain	Residue
B	ARG12
B	TRP116
D	TYR114
D	TRP116
D	HOH177
D	HOH182

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 157

Chain	Residue
D	ASN22
D	ALA23
D	ILE24
D	HIS139

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 D 158

Chain	Residue
A	LEU70
A	THR71
A	ILE72
D	LEU70
D	THR71
D	ILE72

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 159

Chain	Residue
B	ARG115
D	ASP100
D	TYR101
D	ASP102

site_id	BC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 160

Chain	Residue
D	LYS42
D	TYR82
D	ALA84

Functional Information from PROSITE/UniProt

site_id	PS00893
Number of Residues	22
Details	NUDIX_BOX Nudix box signature. GhvepgEddleTAlRETqEEaG

Chain	Residue	Details
A	GLY43-GLY64

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	84
Details	Motif: {"description":"Nudix box"}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)