3TW8

GEF domain of DENND 1B in complex with Rab GTPase Rab35

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005085	molecular_function	guanyl-nucleotide exchange factor activity
B	0000166	molecular_function	nucleotide binding
B	0000281	biological_process	mitotic cytokinesis
B	0003924	molecular_function	GTPase activity
B	0003925	molecular_function	G protein activity
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
B	0005768	cellular_component	endosome
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005905	cellular_component	clathrin-coated pit
B	0008104	biological_process	protein localization
B	0010008	cellular_component	endosome membrane
B	0015031	biological_process	protein transport
B	0016020	cellular_component	membrane
B	0016197	biological_process	endosomal transport
B	0016787	molecular_function	hydrolase activity
B	0019003	molecular_function	GDP binding
B	0019882	biological_process	antigen processing and presentation
B	0030136	cellular_component	clathrin-coated vesicle
B	0030669	cellular_component	clathrin-coated endocytic vesicle membrane
B	0031175	biological_process	neuron projection development
B	0031253	cellular_component	cell projection membrane
B	0031410	cellular_component	cytoplasmic vesicle
B	0032456	biological_process	endocytic recycling
B	0036010	biological_process	protein localization to endosome
B	0042470	cellular_component	melanosome
B	0045171	cellular_component	intercellular bridge
B	0045334	cellular_component	clathrin-coated endocytic vesicle
B	0046872	molecular_function	metal ion binding
B	0048227	biological_process	plasma membrane to endosome transport
B	0055038	cellular_component	recycling endosome membrane
B	0070062	cellular_component	extracellular exosome
B	1990090	biological_process	cellular response to nerve growth factor stimulus
C	0005085	molecular_function	guanyl-nucleotide exchange factor activity
D	0000166	molecular_function	nucleotide binding
D	0000281	biological_process	mitotic cytokinesis
D	0003924	molecular_function	GTPase activity
D	0003925	molecular_function	G protein activity
D	0005515	molecular_function	protein binding
D	0005525	molecular_function	GTP binding
D	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
D	0005768	cellular_component	endosome
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0005905	cellular_component	clathrin-coated pit
D	0008104	biological_process	protein localization
D	0010008	cellular_component	endosome membrane
D	0015031	biological_process	protein transport
D	0016020	cellular_component	membrane
D	0016197	biological_process	endosomal transport
D	0016787	molecular_function	hydrolase activity
D	0019003	molecular_function	GDP binding
D	0019882	biological_process	antigen processing and presentation
D	0030136	cellular_component	clathrin-coated vesicle
D	0030669	cellular_component	clathrin-coated endocytic vesicle membrane
D	0031175	biological_process	neuron projection development
D	0031253	cellular_component	cell projection membrane
D	0031410	cellular_component	cytoplasmic vesicle
D	0032456	biological_process	endocytic recycling
D	0036010	biological_process	protein localization to endosome
D	0042470	cellular_component	melanosome
D	0045171	cellular_component	intercellular bridge
D	0045334	cellular_component	clathrin-coated endocytic vesicle
D	0046872	molecular_function	metal ion binding
D	0048227	biological_process	plasma membrane to endosome transport
D	0055038	cellular_component	recycling endosome membrane
D	0070062	cellular_component	extracellular exosome
D	1990090	biological_process	cellular response to nerve growth factor stimulus

Functional Information from PROSITE/UniProt

site_id	PS00675
Number of Residues	14
Details	SIGMA54_INTERACT_1 Sigma-54 interaction domain ATP-binding region A signature. LLIiGDSGVGKssL

Chain	Residue	Details
B	LEU11-LEU24

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	272
Details	Domain: {"description":"cDENN","evidences":[{"source":"PROSITE-ProRule","id":"PRU00304","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	129
Details	Domain: {"description":"uDENN","evidences":[{"source":"PROSITE-ProRule","id":"PRU00304","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	32
Details	Motif: {"description":"Switch 2","evidences":[{"source":"PubMed","id":"30905672","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IF2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6IF3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30905672","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IF2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6IF3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30905672","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IF2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine; by LRRK2","evidences":[{"source":"PubMed","id":"29125462","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"O-(2-cholinephosphoryl)serine","evidences":[{"source":"PubMed","id":"21822290","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22307087","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"O-AMP-tyrosine","evidences":[{"source":"PubMed","id":"21822290","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---