3T7A

Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with ADP at pH 5.2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000829	molecular_function	diphosphoinositol pentakisphosphate kinase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	26
Details	BINDING SITE FOR RESIDUE ADP A 401

Chain	Residue
A	HOH16
A	GLU238
A	PHE239
A	MET240
A	ASP246
A	SER264
A	PRO265
A	ASP309
A	LEU311
A	CYS320
A	ASP321
A	HOH22
A	HOH404
A	HOH462
A	HOH465
A	HOH470
A	HOH553
A	MG601
A	MG602
A	ARG134
A	PRO149
A	VAL185
A	LYS187
A	HIS194
A	LEU211
A	GLU237

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 601

Chain	Residue
A	HOH22
A	ASP321
A	ASN323
A	ADP401
A	HOH465

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 602

Chain	Residue
A	HOH16
A	ASP309
A	ASP321
A	ADP401
A	HOH462

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 603

Chain	Residue
A	SER68
A	PHE70
A	ILE73
A	HOH491
A	HOH528
A	HOH674

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT A 1

Chain	Residue
A	VAL121
A	ASP124
A	LEU125
A	ASN126
A	HOH578
A	HOH651

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 2

Chain	Residue
A	HOH27
A	ASN90
A	TRP91
A	PRO92
A	ILE285
A	HOH620

---

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ACT A 3

Chain	Residue
A	SER217
A	ARG218
A	LYS270
A	LYS291
A	LEU292
A	TRP295
A	HOH482

---

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 4

Chain	Residue
A	TYR250
A	GLY307
A	PHE308
A	ASP309
A	ASN323
A	SER326
A	HOH372

---

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 5

Chain	Residue
A	ARG312
A	ALA313
A	GLY315
A	GLN316
A	SER317
A	HOH566
A	HOH619

---

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 6

Chain	Residue
A	GLU89
A	ASN90
A	TYR256
A	HIS258
A	LYS333
A	TYR334
A	HOH684

---

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACT A 7

Chain	Residue
A	PHE70
A	HOH498

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 8

Chain	Residue
A	PHE105
A	PRO106
A	LEU107
A	ASP108
A	HOH473
A	HOH556

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22119861","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3T9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9F","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22119861","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3T54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T7A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T99","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9F","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22119861","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3T9A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9D","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22119861","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3T54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9D","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22119861","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3T9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9F","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22119861","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3T54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T7A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22119861","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3T54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T7A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T99","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9F","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22119861","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3T54","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22119861","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3T9D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T9E","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---