3SYZ

Crystal structure of the large fragment of DNA polymerase I from Thermus Aquaticus in an open binary complex with dNaM as templating nucleobase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001882	molecular_function	nucleoside binding
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0006260	biological_process	DNA replication
A	0006261	biological_process	DNA-templated DNA replication
A	0006281	biological_process	DNA repair

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FMT A 1

Chain	Residue
A	ARG617
A	PHE632
A	GLY635
A	GLU818

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FMT A 835

Chain	Residue
A	HOH115
A	ARG393
A	ALA464
A	HOH893

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE FMT A 3

Chain	Residue
A	ASN483
A	LEU484
A	PHE475

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FMT A 5

Chain	Residue
A	HOH266
A	HOH285
A	HIS443
A	THR447

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE FMT A 7

Chain	Residue
A	ARG313
A	LEU552
C	HOH238

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 833

Chain	Residue
A	HOH42
A	HOH232
A	HOH269
A	ARG425
A	TRP428
A	PHE724
A	TYR811

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 834

Chain	Residue
A	HOH168
A	HOH237
A	LEU451
A	ASP452
A	VAL453
A	ALA454

---

site_id	AC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 6

Chain	Residue
A	HOH147
A	THR544
A	TYR545
A	PRO579
A	ASN580
A	ASN583
C	GOL1
C	DC209
C	DC210

---

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 9

Chain	Residue
A	HOH271
A	ASP452
A	TYR455
A	TYR455
A	ARG596
A	ARG596
A	ILE599
A	ASP826

---

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 2

Chain	Residue
A	TYR671
A	GLY672
A	GLU742
A	GLU745
A	ARG746
A	PHE749
A	HOH862

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FMT A 836

Chain	Residue
A	THR447
A	ARG559
A	ARG778
A	HOH897
A	HOH898

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 837

Chain	Residue
A	GLU786
A	HOH856
A	HOH857
A	HOH858
A	HOH859
A	HOH860

---

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 1

Chain	Residue
B	HOH2
B	HOH3
B	HOH5
B	HOH6
B	HOH113
C	HOH220

---

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL C 2

Chain	Residue
C	DG213
C	DG214

---

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL C 5

Chain	Residue
B	HOH5
C	HOH159
C	DC207
C	DG208
C	HOH220
C	HOH221

---

site_id	BC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL C 7

Chain	Residue
A	ARG728
C	DG206
C	DC207

---

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL C 1

Chain	Residue
A	GOL6
A	ASP578
A	PRO579
C	DC209
C	DC210
C	HOH238

---

site_id	BC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL C 3

Chain	Residue
B	DC111
C	HOH126
C	HOH131
C	DA203
C	BMN204
C	DG205
C	DG206

---

Functional Information from PROSITE/UniProt

site_id	PS00447
Number of Residues	20
Details	DNA_POLYMERASE_A DNA polymerase family A signature. RraAKtinFGvlYgmSahrL

Chain	Residue	Details
A	ARG659-LEU678

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	422
Details	Region: {"description":"Polymerase","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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