Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3SL9

X-ray structure of Beta catenin in complex with Bcl9

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0007155	biological_process	cell adhesion
A	0045296	molecular_function	cadherin binding
B	0007155	biological_process	cell adhesion
B	0045296	molecular_function	cadherin binding
C	0003713	molecular_function	transcription coactivator activity
C	0008013	molecular_function	beta-catenin binding
C	0060070	biological_process	canonical Wnt signaling pathway
D	0003713	molecular_function	transcription coactivator activity
D	0008013	molecular_function	beta-catenin binding
D	0060070	biological_process	canonical Wnt signaling pathway
E	0007155	biological_process	cell adhesion
E	0045296	molecular_function	cadherin binding
F	0003713	molecular_function	transcription coactivator activity
F	0008013	molecular_function	beta-catenin binding
F	0060070	biological_process	canonical Wnt signaling pathway
G	0007155	biological_process	cell adhesion
G	0045296	molecular_function	cadherin binding
H	0003713	molecular_function	transcription coactivator activity
H	0008013	molecular_function	beta-catenin binding
H	0060070	biological_process	canonical Wnt signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 1

Chain	Residue
A	ASP299
A	GLN302

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 2

Chain	Residue
A	GLU163
A	GLN165

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PEG A 306

Chain	Residue
E	LYS288
A	ASP249
A	LYS288
A	THR289
A	ASN290
A	PHE293

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IMD A 307

Chain	Residue
A	THR205
A	SER246

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO C 3

Chain	Residue
C	LEU351
C	GLN353
E	MET243
E	SER246

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 5

Chain	Residue
A	HOH87
A	ARG274
B	GLN280

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PEG C 2

Chain	Residue
C	HOH49
C	HOH51
C	GLU357
E	ALA276
E	GLY277

site_id	AC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE GOL B 308

Chain	Residue
B	ASP299

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL B 309

Chain	Residue
B	SER222
B	HIS223
B	HIS265

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO B 4

Chain	Residue
B	HIS176
B	LYS180
B	ASN220
B	TYR254

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO B 7

Chain	Residue
B	PHE253
B	LYS292

site_id	BC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO B 6

Chain	Residue
B	HOH89
B	LEU263

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PEG B 3

Chain	Residue
A	MET271
B	HOH78
B	LYS281
B	LEU285

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PEG B 306

Chain	Residue
B	HOH58
B	THR205
B	ASN206
B	LYS242

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IMD B 307

Chain	Residue
A	PRO238
B	GLN203

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO E 8

Chain	Residue
E	HOH93
E	GLY235
E	PRO238
E	ALA272
F	GOL4

site_id	BC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE GOL E 2

Chain	Residue
E	ASP299

site_id	BC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO E 9

Chain	Residue
C	GLU360
E	GLY245

site_id	CC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EDO E 10

Chain	Residue
E	LYS292

site_id	CC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO E 11

Chain	Residue
E	PHE232
E	GLU267
E	GLY268
F	GLN364
F	ASP368
F	ARG371

site_id	CC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PEG E 5

Chain	Residue
E	HOH125
E	ARG151
E	ARG274
E	GLN280
G	ALA305

site_id	CC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IMD E 4

Chain	Residue
E	LYS158

site_id	CC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL F 4

Chain	Residue
E	EDO8
E	ALA272
E	ALA276
F	MET372

site_id	CC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL G 1

Chain	Residue
A	HIS260
G	HOH316

site_id	CC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IMD G 5

Chain	Residue
A	HOH17
G	HIS260

site_id	CC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IMD G 7

Chain	Residue
G	ASP299
G	GLN302

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	160
Details	Repeat: {"description":"ARM 1"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	164
Details	Repeat: {"description":"ARM 2"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	164
Details	Repeat: {"description":"ARM 3"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	88
Details	Region: {"description":"Interaction with BCL9","evidences":[{"source":"PubMed","id":"17052462","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	3
Details	Modified residue: {"description":"Phosphotyrosine; by FYN and PTK6","evidences":[{"source":"PubMed","id":"12640114","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20026641","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by CDK5","evidences":[{"source":"PubMed","id":"17009320","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by CDK5","evidences":[{"source":"PubMed","id":"17009320","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	48
Details	Region: {"description":"Interaction with CTNNB1","evidences":[{"source":"PubMed","id":"17052462","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9D219","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)