3SHF
Crystal structure of the R265S mutant of full-length murine Apaf-1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0001666 | biological_process | response to hypoxia |
| A | 0001822 | biological_process | kidney development |
| A | 0001843 | biological_process | neural tube closure |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006915 | biological_process | apoptotic process |
| A | 0007420 | biological_process | brain development |
| A | 0007584 | biological_process | response to nutrient |
| A | 0008656 | molecular_function | cysteine-type endopeptidase activator activity involved in apoptotic process |
| A | 0010659 | biological_process | cardiac muscle cell apoptotic process |
| A | 0030154 | biological_process | cell differentiation |
| A | 0030900 | biological_process | forebrain development |
| A | 0031072 | molecular_function | heat shock protein binding |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042981 | biological_process | regulation of apoptotic process |
| A | 0043065 | biological_process | positive regulation of apoptotic process |
| A | 0043293 | cellular_component | apoptosome |
| A | 0043531 | molecular_function | ADP binding |
| A | 0048731 | biological_process | system development |
| A | 0051402 | biological_process | neuron apoptotic process |
| A | 0070059 | biological_process | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
| A | 0071560 | biological_process | cellular response to transforming growth factor beta stimulus |
| A | 0097190 | biological_process | apoptotic signaling pathway |
| A | 0097193 | biological_process | intrinsic apoptotic signaling pathway |
| A | 1902510 | biological_process | regulation of apoptotic DNA fragmentation |
| A | 2001235 | biological_process | positive regulation of apoptotic signaling pathway |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE ADP A 1250 |
| Chain | Residue |
| A | PRO123 |
| A | LYS160 |
| A | SER161 |
| A | VAL162 |
| A | PRO321 |
| A | LEU322 |
| A | SER325 |
| A | PHE425 |
| A | HIS438 |
| A | ILE125 |
| A | PHE126 |
| A | VAL127 |
| A | ARG129 |
| A | ALA156 |
| A | GLY157 |
| A | CYS158 |
| A | GLY159 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GBL A 1251 |
| Chain | Residue |
| A | SER387 |
| A | ILE388 |
| A | LEU389 |
| A | THR446 |
| A | LEU453 |
| A | HIS457 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GBL A 1252 |
| Chain | Residue |
| A | ASP191 |
| A | HIS521 |
| A | HIS524 |
Functional Information from PROSITE/UniProt
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. IATCsaDkKVKIWDS |
| Chain | Residue | Details |
| A | ILE672-SER686 | |
| A | LEU716-LEU730 | |
| A | LEU758-VAL772 | |
| A | LEU1142-VAL1156 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 309 |
| Details | Domain: {"description":"NB-ARC"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"WD 1-1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21827944","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"WD 1-2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21827944","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 41 |
| Details | Repeat: {"description":"WD 1-3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21827944","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"WD 1-4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21827944","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 41 |
| Details | Repeat: {"description":"WD 1-5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21827944","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"WD 1-6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21827944","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 30 |
| Details | Repeat: {"description":"WD 1-7","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21827944","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 36 |
| Details | Repeat: {"description":"WD 2-1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21827944","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"WD 2-2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21827944","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"WD 2-3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21827944","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 38 |
| Details | Repeat: {"description":"WD 2-4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21827944","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"WD 2-5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21827944","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"WD 2-6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21827944","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 35 |
| Details | Repeat: {"description":"WD 2-8","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21827944","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 11 |
| Details | Region: {"description":"Interpropeller linker"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 1 |
| Details | Binding site: {} |
| Chain | Residue | Details |
