3SDL

Crystal structure of human ISG15 in complex with NS1 N-terminal region from influenza B virus, Northeast Structural Genomics Consortium Target IDs HX6481, HR2873, and OR2

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0002376	biological_process	immune system process
C	0002682	biological_process	regulation of immune system process
C	0003735	molecular_function	structural constituent of ribosome
C	0005178	molecular_function	integrin binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0007229	biological_process	integrin-mediated signaling pathway
C	0009615	biological_process	response to virus
C	0019941	biological_process	modification-dependent protein catabolic process
C	0022626	cellular_component	cytosolic ribosome
C	0030501	biological_process	positive regulation of bone mineralization
C	0031386	molecular_function	protein tag activity
C	0031397	biological_process	negative regulation of protein ubiquitination
C	0032020	biological_process	ISG15-protein conjugation
C	0032461	biological_process	positive regulation of protein oligomerization
C	0032649	biological_process	regulation of type II interferon production
C	0032728	biological_process	positive regulation of interferon-beta production
C	0032729	biological_process	positive regulation of type II interferon production
C	0032733	biological_process	positive regulation of interleukin-10 production
C	0034340	biological_process	response to type I interferon
C	0042742	biological_process	defense response to bacterium
C	0045071	biological_process	negative regulation of viral genome replication
C	0045087	biological_process	innate immune response
C	0045648	biological_process	positive regulation of erythrocyte differentiation
C	0051240	biological_process	positive regulation of multicellular organismal process
C	0051607	biological_process	defense response to virus
C	0060339	biological_process	negative regulation of type I interferon-mediated signaling pathway
C	0070585	biological_process	protein localization to mitochondrion
D	0002376	biological_process	immune system process
D	0002682	biological_process	regulation of immune system process
D	0003735	molecular_function	structural constituent of ribosome
D	0005178	molecular_function	integrin binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0007229	biological_process	integrin-mediated signaling pathway
D	0009615	biological_process	response to virus
D	0019941	biological_process	modification-dependent protein catabolic process
D	0022626	cellular_component	cytosolic ribosome
D	0030501	biological_process	positive regulation of bone mineralization
D	0031386	molecular_function	protein tag activity
D	0031397	biological_process	negative regulation of protein ubiquitination
D	0032020	biological_process	ISG15-protein conjugation
D	0032461	biological_process	positive regulation of protein oligomerization
D	0032649	biological_process	regulation of type II interferon production
D	0032728	biological_process	positive regulation of interferon-beta production
D	0032729	biological_process	positive regulation of type II interferon production
D	0032733	biological_process	positive regulation of interleukin-10 production
D	0034340	biological_process	response to type I interferon
D	0042742	biological_process	defense response to bacterium
D	0045071	biological_process	negative regulation of viral genome replication
D	0045087	biological_process	innate immune response
D	0045648	biological_process	positive regulation of erythrocyte differentiation
D	0051240	biological_process	positive regulation of multicellular organismal process
D	0051607	biological_process	defense response to virus
D	0060339	biological_process	negative regulation of type I interferon-mediated signaling pathway
D	0070585	biological_process	protein localization to mitochondrion

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	Motif: {"description":"Nuclear localization signal","evidences":[{"source":"HAMAP-Rule","id":"MF_04066","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Site: {"description":"Interacts with activating enzyme","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"S-nitrosocysteine; alternate","evidences":[{"source":"PubMed","id":"18606809","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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