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3SBC

Crystal structure of Saccharomyces cerevisiae TSA1C47S mutant protein

Functional Information from GO Data
ChainGOidnamespacecontents
A0000077biological_processDNA damage checkpoint signaling
A0004601molecular_functionperoxidase activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006111biological_processregulation of gluconeogenesis
A0006457biological_processprotein folding
A0006979biological_processresponse to oxidative stress
A0008379molecular_functionthioredoxin peroxidase activity
A0016209molecular_functionantioxidant activity
A0016491molecular_functionoxidoreductase activity
A0019207molecular_functionkinase regulator activity
A0033194biological_processresponse to hydroperoxide
A0034599biological_processcellular response to oxidative stress
A0034605biological_processcellular response to heat
A0042262biological_processDNA protection
A0042744biological_processhydrogen peroxide catabolic process
A0042802molecular_functionidentical protein binding
A0043022molecular_functionribosome binding
A0045454biological_processcell redox homeostasis
A0050821biological_processprotein stabilization
A0051082molecular_functionunfolded protein binding
A0051258biological_processprotein polymerization
A0051920molecular_functionperoxiredoxin activity
A0071447biological_processcellular response to hydroperoxide
A0072721biological_processcellular response to dithiothreitol
A0098869biological_processcellular oxidant detoxification
A0140824molecular_functionthioredoxin-dependent peroxiredoxin activity
B0000077biological_processDNA damage checkpoint signaling
B0004601molecular_functionperoxidase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006111biological_processregulation of gluconeogenesis
B0006457biological_processprotein folding
B0006979biological_processresponse to oxidative stress
B0008379molecular_functionthioredoxin peroxidase activity
B0016209molecular_functionantioxidant activity
B0016491molecular_functionoxidoreductase activity
B0019207molecular_functionkinase regulator activity
B0033194biological_processresponse to hydroperoxide
B0034599biological_processcellular response to oxidative stress
B0034605biological_processcellular response to heat
B0042262biological_processDNA protection
B0042744biological_processhydrogen peroxide catabolic process
B0042802molecular_functionidentical protein binding
B0043022molecular_functionribosome binding
B0045454biological_processcell redox homeostasis
B0050821biological_processprotein stabilization
B0051082molecular_functionunfolded protein binding
B0051258biological_processprotein polymerization
B0051920molecular_functionperoxiredoxin activity
B0071447biological_processcellular response to hydroperoxide
B0072721biological_processcellular response to dithiothreitol
B0098869biological_processcellular oxidant detoxification
B0140824molecular_functionthioredoxin-dependent peroxiredoxin activity
C0000077biological_processDNA damage checkpoint signaling
C0004601molecular_functionperoxidase activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006111biological_processregulation of gluconeogenesis
C0006457biological_processprotein folding
C0006979biological_processresponse to oxidative stress
C0008379molecular_functionthioredoxin peroxidase activity
C0016209molecular_functionantioxidant activity
C0016491molecular_functionoxidoreductase activity
C0019207molecular_functionkinase regulator activity
C0033194biological_processresponse to hydroperoxide
C0034599biological_processcellular response to oxidative stress
C0034605biological_processcellular response to heat
C0042262biological_processDNA protection
C0042744biological_processhydrogen peroxide catabolic process
C0042802molecular_functionidentical protein binding
C0043022molecular_functionribosome binding
C0045454biological_processcell redox homeostasis
C0050821biological_processprotein stabilization
C0051082molecular_functionunfolded protein binding
C0051258biological_processprotein polymerization
C0051920molecular_functionperoxiredoxin activity
C0071447biological_processcellular response to hydroperoxide
C0072721biological_processcellular response to dithiothreitol
C0098869biological_processcellular oxidant detoxification
C0140824molecular_functionthioredoxin-dependent peroxiredoxin activity
D0000077biological_processDNA damage checkpoint signaling
D0004601molecular_functionperoxidase activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006111biological_processregulation of gluconeogenesis
D0006457biological_processprotein folding
D0006979biological_processresponse to oxidative stress
D0008379molecular_functionthioredoxin peroxidase activity
D0016209molecular_functionantioxidant activity
D0016491molecular_functionoxidoreductase activity
D0019207molecular_functionkinase regulator activity
D0033194biological_processresponse to hydroperoxide
D0034599biological_processcellular response to oxidative stress
D0034605biological_processcellular response to heat
D0042262biological_processDNA protection
D0042744biological_processhydrogen peroxide catabolic process
D0042802molecular_functionidentical protein binding
D0043022molecular_functionribosome binding
D0045454biological_processcell redox homeostasis
D0050821biological_processprotein stabilization
D0051082molecular_functionunfolded protein binding
D0051258biological_processprotein polymerization
D0051920molecular_functionperoxiredoxin activity
D0071447biological_processcellular response to hydroperoxide
D0072721biological_processcellular response to dithiothreitol
D0098869biological_processcellular oxidant detoxification
D0140824molecular_functionthioredoxin-dependent peroxiredoxin activity
E0000077biological_processDNA damage checkpoint signaling
E0004601molecular_functionperoxidase activity
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0006111biological_processregulation of gluconeogenesis
E0006457biological_processprotein folding
E0006979biological_processresponse to oxidative stress
E0008379molecular_functionthioredoxin peroxidase activity
E0016209molecular_functionantioxidant activity
E0016491molecular_functionoxidoreductase activity
E0019207molecular_functionkinase regulator activity
E0033194biological_processresponse to hydroperoxide
E0034599biological_processcellular response to oxidative stress
E0034605biological_processcellular response to heat
E0042262biological_processDNA protection
E0042744biological_processhydrogen peroxide catabolic process
E0042802molecular_functionidentical protein binding
E0043022molecular_functionribosome binding
E0045454biological_processcell redox homeostasis
E0050821biological_processprotein stabilization
E0051082molecular_functionunfolded protein binding
E0051258biological_processprotein polymerization
E0051920molecular_functionperoxiredoxin activity
E0071447biological_processcellular response to hydroperoxide
E0072721biological_processcellular response to dithiothreitol
E0098869biological_processcellular oxidant detoxification
E0140824molecular_functionthioredoxin-dependent peroxiredoxin activity
F0000077biological_processDNA damage checkpoint signaling
F0004601molecular_functionperoxidase activity
F0005515molecular_functionprotein binding
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0006111biological_processregulation of gluconeogenesis
F0006457biological_processprotein folding
F0006979biological_processresponse to oxidative stress
F0008379molecular_functionthioredoxin peroxidase activity
F0016209molecular_functionantioxidant activity
F0016491molecular_functionoxidoreductase activity
F0019207molecular_functionkinase regulator activity
F0033194biological_processresponse to hydroperoxide
F0034599biological_processcellular response to oxidative stress
F0034605biological_processcellular response to heat
F0042262biological_processDNA protection
F0042744biological_processhydrogen peroxide catabolic process
F0042802molecular_functionidentical protein binding
F0043022molecular_functionribosome binding
F0045454biological_processcell redox homeostasis
F0050821biological_processprotein stabilization
F0051082molecular_functionunfolded protein binding
F0051258biological_processprotein polymerization
F0051920molecular_functionperoxiredoxin activity
F0071447biological_processcellular response to hydroperoxide
F0072721biological_processcellular response to dithiothreitol
F0098869biological_processcellular oxidant detoxification
F0140824molecular_functionthioredoxin-dependent peroxiredoxin activity
G0000077biological_processDNA damage checkpoint signaling
G0004601molecular_functionperoxidase activity
G0005515molecular_functionprotein binding
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0006111biological_processregulation of gluconeogenesis
G0006457biological_processprotein folding
G0006979biological_processresponse to oxidative stress
G0008379molecular_functionthioredoxin peroxidase activity
G0016209molecular_functionantioxidant activity
G0016491molecular_functionoxidoreductase activity
G0019207molecular_functionkinase regulator activity
G0033194biological_processresponse to hydroperoxide
G0034599biological_processcellular response to oxidative stress
G0034605biological_processcellular response to heat
G0042262biological_processDNA protection
G0042744biological_processhydrogen peroxide catabolic process
G0042802molecular_functionidentical protein binding
G0043022molecular_functionribosome binding
G0045454biological_processcell redox homeostasis
G0050821biological_processprotein stabilization
G0051082molecular_functionunfolded protein binding
G0051258biological_processprotein polymerization
G0051920molecular_functionperoxiredoxin activity
G0071447biological_processcellular response to hydroperoxide
G0072721biological_processcellular response to dithiothreitol
G0098869biological_processcellular oxidant detoxification
G0140824molecular_functionthioredoxin-dependent peroxiredoxin activity
H0000077biological_processDNA damage checkpoint signaling
H0004601molecular_functionperoxidase activity
H0005515molecular_functionprotein binding
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0006111biological_processregulation of gluconeogenesis
H0006457biological_processprotein folding
H0006979biological_processresponse to oxidative stress
H0008379molecular_functionthioredoxin peroxidase activity
H0016209molecular_functionantioxidant activity
H0016491molecular_functionoxidoreductase activity
H0019207molecular_functionkinase regulator activity
H0033194biological_processresponse to hydroperoxide
H0034599biological_processcellular response to oxidative stress
H0034605biological_processcellular response to heat
H0042262biological_processDNA protection
H0042744biological_processhydrogen peroxide catabolic process
H0042802molecular_functionidentical protein binding
H0043022molecular_functionribosome binding
H0045454biological_processcell redox homeostasis
H0050821biological_processprotein stabilization
H0051082molecular_functionunfolded protein binding
H0051258biological_processprotein polymerization
H0051920molecular_functionperoxiredoxin activity
H0071447biological_processcellular response to hydroperoxide
H0072721biological_processcellular response to dithiothreitol
H0098869biological_processcellular oxidant detoxification
H0140824molecular_functionthioredoxin-dependent peroxiredoxin activity
I0000077biological_processDNA damage checkpoint signaling
I0004601molecular_functionperoxidase activity
I0005515molecular_functionprotein binding
I0005737cellular_componentcytoplasm
I0005829cellular_componentcytosol
I0006111biological_processregulation of gluconeogenesis
I0006457biological_processprotein folding
I0006979biological_processresponse to oxidative stress
I0008379molecular_functionthioredoxin peroxidase activity
I0016209molecular_functionantioxidant activity
I0016491molecular_functionoxidoreductase activity
I0019207molecular_functionkinase regulator activity
I0033194biological_processresponse to hydroperoxide
I0034599biological_processcellular response to oxidative stress
I0034605biological_processcellular response to heat
I0042262biological_processDNA protection
I0042744biological_processhydrogen peroxide catabolic process
I0042802molecular_functionidentical protein binding
I0043022molecular_functionribosome binding
I0045454biological_processcell redox homeostasis
I0050821biological_processprotein stabilization
I0051082molecular_functionunfolded protein binding
I0051258biological_processprotein polymerization
I0051920molecular_functionperoxiredoxin activity
I0071447biological_processcellular response to hydroperoxide
I0072721biological_processcellular response to dithiothreitol
I0098869biological_processcellular oxidant detoxification
I0140824molecular_functionthioredoxin-dependent peroxiredoxin activity
J0000077biological_processDNA damage checkpoint signaling
J0004601molecular_functionperoxidase activity
J0005515molecular_functionprotein binding
J0005737cellular_componentcytoplasm
J0005829cellular_componentcytosol
J0006111biological_processregulation of gluconeogenesis
J0006457biological_processprotein folding
J0006979biological_processresponse to oxidative stress
J0008379molecular_functionthioredoxin peroxidase activity
J0016209molecular_functionantioxidant activity
J0016491molecular_functionoxidoreductase activity
J0019207molecular_functionkinase regulator activity
J0033194biological_processresponse to hydroperoxide
J0034599biological_processcellular response to oxidative stress
J0034605biological_processcellular response to heat
J0042262biological_processDNA protection
J0042744biological_processhydrogen peroxide catabolic process
J0042802molecular_functionidentical protein binding
J0043022molecular_functionribosome binding
J0045454biological_processcell redox homeostasis
J0050821biological_processprotein stabilization
J0051082molecular_functionunfolded protein binding
J0051258biological_processprotein polymerization
J0051920molecular_functionperoxiredoxin activity
J0071447biological_processcellular response to hydroperoxide
J0072721biological_processcellular response to dithiothreitol
J0098869biological_processcellular oxidant detoxification
J0140824molecular_functionthioredoxin-dependent peroxiredoxin activity
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE DTU B 201
ChainResidue
BPRO40
BTHR44
BPHE45
BVAL46
BSER47
BARG123

site_idAC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE DTV C 201
ChainResidue
CVAL46
CSER47
CARG123
CLEU142
CPRO40
CTHR44
CPHE45

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE DTU E 201
ChainResidue
ELEU41
ETHR44
EPHE45
EVAL46
ESER47
EARG123
ELEU142

site_idAC4
Number of Residues7
DetailsBINDING SITE FOR RESIDUE DTU G 201
ChainResidue
GTHR44
GPHE45
GVAL46
GSER47
GARG123
GLEU142
HVAL167

site_idAC5
Number of Residues8
DetailsBINDING SITE FOR RESIDUE DTU H 201
ChainResidue
GVAL167
HPRO40
HTHR44
HPHE45
HVAL46
HSER47
HARG123
HHOH322

site_idAC6
Number of Residues5
DetailsBINDING SITE FOR RESIDUE DTU J 201
ChainResidue
ATYR77
JTHR44
JPHE45
JVAL46
JARG123

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1580
DetailsDomain: {"description":"Thioredoxin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00691","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues10
DetailsActive site: {"description":"Cysteine sulfenic acid (-SOH) intermediate","evidences":[{"source":"PubMed","id":"8041739","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues30
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"22985967","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3SBC","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues10
DetailsSite: {"description":"Important for catalytic activity, helps activating the peroxidatic cysteine through H-bonding"}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues10
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues40
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22106047","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

242842

PDB entries from 2025-10-08

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