Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

3SBC

Crystal structure of Saccharomyces cerevisiae TSA1C47S mutant protein

Functional Information from GO Data
ChainGOidnamespacecontents
A0000077biological_processDNA damage checkpoint signaling
A0004601molecular_functionperoxidase activity
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006111biological_processregulation of gluconeogenesis
A0006457biological_processprotein folding
A0006979biological_processresponse to oxidative stress
A0008379molecular_functionthioredoxin peroxidase activity
A0016209molecular_functionantioxidant activity
A0016491molecular_functionoxidoreductase activity
A0019207molecular_functionkinase regulator activity
A0033194biological_processresponse to hydroperoxide
A0034599biological_processcellular response to oxidative stress
A0034605biological_processcellular response to heat
A0042262biological_processDNA protection
A0042744biological_processhydrogen peroxide catabolic process
A0042802molecular_functionidentical protein binding
A0043022molecular_functionribosome binding
A0045454biological_processcell redox homeostasis
A0050821biological_processprotein stabilization
A0051082molecular_functionunfolded protein binding
A0051258biological_processprotein polymerization
A0051920molecular_functionperoxiredoxin activity
A0061077biological_processchaperone-mediated protein folding
A0071447biological_processcellular response to hydroperoxide
A0072721biological_processcellular response to dithiothreitol
A0098869biological_processcellular oxidant detoxification
A0140824molecular_functionthioredoxin-dependent peroxiredoxin activity
B0000077biological_processDNA damage checkpoint signaling
B0004601molecular_functionperoxidase activity
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006111biological_processregulation of gluconeogenesis
B0006457biological_processprotein folding
B0006979biological_processresponse to oxidative stress
B0008379molecular_functionthioredoxin peroxidase activity
B0016209molecular_functionantioxidant activity
B0016491molecular_functionoxidoreductase activity
B0019207molecular_functionkinase regulator activity
B0033194biological_processresponse to hydroperoxide
B0034599biological_processcellular response to oxidative stress
B0034605biological_processcellular response to heat
B0042262biological_processDNA protection
B0042744biological_processhydrogen peroxide catabolic process
B0042802molecular_functionidentical protein binding
B0043022molecular_functionribosome binding
B0045454biological_processcell redox homeostasis
B0050821biological_processprotein stabilization
B0051082molecular_functionunfolded protein binding
B0051258biological_processprotein polymerization
B0051920molecular_functionperoxiredoxin activity
B0061077biological_processchaperone-mediated protein folding
B0071447biological_processcellular response to hydroperoxide
B0072721biological_processcellular response to dithiothreitol
B0098869biological_processcellular oxidant detoxification
B0140824molecular_functionthioredoxin-dependent peroxiredoxin activity
C0000077biological_processDNA damage checkpoint signaling
C0004601molecular_functionperoxidase activity
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006111biological_processregulation of gluconeogenesis
C0006457biological_processprotein folding
C0006979biological_processresponse to oxidative stress
C0008379molecular_functionthioredoxin peroxidase activity
C0016209molecular_functionantioxidant activity
C0016491molecular_functionoxidoreductase activity
C0019207molecular_functionkinase regulator activity
C0033194biological_processresponse to hydroperoxide
C0034599biological_processcellular response to oxidative stress
C0034605biological_processcellular response to heat
C0042262biological_processDNA protection
C0042744biological_processhydrogen peroxide catabolic process
C0042802molecular_functionidentical protein binding
C0043022molecular_functionribosome binding
C0045454biological_processcell redox homeostasis
C0050821biological_processprotein stabilization
C0051082molecular_functionunfolded protein binding
C0051258biological_processprotein polymerization
C0051920molecular_functionperoxiredoxin activity
C0061077biological_processchaperone-mediated protein folding
C0071447biological_processcellular response to hydroperoxide
C0072721biological_processcellular response to dithiothreitol
C0098869biological_processcellular oxidant detoxification
C0140824molecular_functionthioredoxin-dependent peroxiredoxin activity
D0000077biological_processDNA damage checkpoint signaling
D0004601molecular_functionperoxidase activity
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006111biological_processregulation of gluconeogenesis
D0006457biological_processprotein folding
D0006979biological_processresponse to oxidative stress
D0008379molecular_functionthioredoxin peroxidase activity
D0016209molecular_functionantioxidant activity
D0016491molecular_functionoxidoreductase activity
D0019207molecular_functionkinase regulator activity
D0033194biological_processresponse to hydroperoxide
D0034599biological_processcellular response to oxidative stress
D0034605biological_processcellular response to heat
D0042262biological_processDNA protection
D0042744biological_processhydrogen peroxide catabolic process
D0042802molecular_functionidentical protein binding
D0043022molecular_functionribosome binding
D0045454biological_processcell redox homeostasis
D0050821biological_processprotein stabilization
D0051082molecular_functionunfolded protein binding
D0051258biological_processprotein polymerization
D0051920molecular_functionperoxiredoxin activity
D0061077biological_processchaperone-mediated protein folding
D0071447biological_processcellular response to hydroperoxide
D0072721biological_processcellular response to dithiothreitol
D0098869biological_processcellular oxidant detoxification
D0140824molecular_functionthioredoxin-dependent peroxiredoxin activity
E0000077biological_processDNA damage checkpoint signaling
E0004601molecular_functionperoxidase activity
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0006111biological_processregulation of gluconeogenesis
E0006457biological_processprotein folding
E0006979biological_processresponse to oxidative stress
E0008379molecular_functionthioredoxin peroxidase activity
E0016209molecular_functionantioxidant activity
E0016491molecular_functionoxidoreductase activity
E0019207molecular_functionkinase regulator activity
E0033194biological_processresponse to hydroperoxide
E0034599biological_processcellular response to oxidative stress
E0034605biological_processcellular response to heat
E0042262biological_processDNA protection
E0042744biological_processhydrogen peroxide catabolic process
E0042802molecular_functionidentical protein binding
E0043022molecular_functionribosome binding
E0045454biological_processcell redox homeostasis
E0050821biological_processprotein stabilization
E0051082molecular_functionunfolded protein binding
E0051258biological_processprotein polymerization
E0051920molecular_functionperoxiredoxin activity
E0061077biological_processchaperone-mediated protein folding
E0071447biological_processcellular response to hydroperoxide
E0072721biological_processcellular response to dithiothreitol
E0098869biological_processcellular oxidant detoxification
E0140824molecular_functionthioredoxin-dependent peroxiredoxin activity
F0000077biological_processDNA damage checkpoint signaling
F0004601molecular_functionperoxidase activity
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0006111biological_processregulation of gluconeogenesis
F0006457biological_processprotein folding
F0006979biological_processresponse to oxidative stress
F0008379molecular_functionthioredoxin peroxidase activity
F0016209molecular_functionantioxidant activity
F0016491molecular_functionoxidoreductase activity
F0019207molecular_functionkinase regulator activity
F0033194biological_processresponse to hydroperoxide
F0034599biological_processcellular response to oxidative stress
F0034605biological_processcellular response to heat
F0042262biological_processDNA protection
F0042744biological_processhydrogen peroxide catabolic process
F0042802molecular_functionidentical protein binding
F0043022molecular_functionribosome binding
F0045454biological_processcell redox homeostasis
F0050821biological_processprotein stabilization
F0051082molecular_functionunfolded protein binding
F0051258biological_processprotein polymerization
F0051920molecular_functionperoxiredoxin activity
F0061077biological_processchaperone-mediated protein folding
F0071447biological_processcellular response to hydroperoxide
F0072721biological_processcellular response to dithiothreitol
F0098869biological_processcellular oxidant detoxification
F0140824molecular_functionthioredoxin-dependent peroxiredoxin activity
G0000077biological_processDNA damage checkpoint signaling
G0004601molecular_functionperoxidase activity
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0006111biological_processregulation of gluconeogenesis
G0006457biological_processprotein folding
G0006979biological_processresponse to oxidative stress
G0008379molecular_functionthioredoxin peroxidase activity
G0016209molecular_functionantioxidant activity
G0016491molecular_functionoxidoreductase activity
G0019207molecular_functionkinase regulator activity
G0033194biological_processresponse to hydroperoxide
G0034599biological_processcellular response to oxidative stress
G0034605biological_processcellular response to heat
G0042262biological_processDNA protection
G0042744biological_processhydrogen peroxide catabolic process
G0042802molecular_functionidentical protein binding
G0043022molecular_functionribosome binding
G0045454biological_processcell redox homeostasis
G0050821biological_processprotein stabilization
G0051082molecular_functionunfolded protein binding
G0051258biological_processprotein polymerization
G0051920molecular_functionperoxiredoxin activity
G0061077biological_processchaperone-mediated protein folding
G0071447biological_processcellular response to hydroperoxide
G0072721biological_processcellular response to dithiothreitol
G0098869biological_processcellular oxidant detoxification
G0140824molecular_functionthioredoxin-dependent peroxiredoxin activity
H0000077biological_processDNA damage checkpoint signaling
H0004601molecular_functionperoxidase activity
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0006111biological_processregulation of gluconeogenesis
H0006457biological_processprotein folding
H0006979biological_processresponse to oxidative stress
H0008379molecular_functionthioredoxin peroxidase activity
H0016209molecular_functionantioxidant activity
H0016491molecular_functionoxidoreductase activity
H0019207molecular_functionkinase regulator activity
H0033194biological_processresponse to hydroperoxide
H0034599biological_processcellular response to oxidative stress
H0034605biological_processcellular response to heat
H0042262biological_processDNA protection
H0042744biological_processhydrogen peroxide catabolic process
H0042802molecular_functionidentical protein binding
H0043022molecular_functionribosome binding
H0045454biological_processcell redox homeostasis
H0050821biological_processprotein stabilization
H0051082molecular_functionunfolded protein binding
H0051258biological_processprotein polymerization
H0051920molecular_functionperoxiredoxin activity
H0061077biological_processchaperone-mediated protein folding
H0071447biological_processcellular response to hydroperoxide
H0072721biological_processcellular response to dithiothreitol
H0098869biological_processcellular oxidant detoxification
H0140824molecular_functionthioredoxin-dependent peroxiredoxin activity
I0000077biological_processDNA damage checkpoint signaling
I0004601molecular_functionperoxidase activity
I0005737cellular_componentcytoplasm
I0005829cellular_componentcytosol
I0006111biological_processregulation of gluconeogenesis
I0006457biological_processprotein folding
I0006979biological_processresponse to oxidative stress
I0008379molecular_functionthioredoxin peroxidase activity
I0016209molecular_functionantioxidant activity
I0016491molecular_functionoxidoreductase activity
I0019207molecular_functionkinase regulator activity
I0033194biological_processresponse to hydroperoxide
I0034599biological_processcellular response to oxidative stress
I0034605biological_processcellular response to heat
I0042262biological_processDNA protection
I0042744biological_processhydrogen peroxide catabolic process
I0042802molecular_functionidentical protein binding
I0043022molecular_functionribosome binding
I0045454biological_processcell redox homeostasis
I0050821biological_processprotein stabilization
I0051082molecular_functionunfolded protein binding
I0051258biological_processprotein polymerization
I0051920molecular_functionperoxiredoxin activity
I0061077biological_processchaperone-mediated protein folding
I0071447biological_processcellular response to hydroperoxide
I0072721biological_processcellular response to dithiothreitol
I0098869biological_processcellular oxidant detoxification
I0140824molecular_functionthioredoxin-dependent peroxiredoxin activity
J0000077biological_processDNA damage checkpoint signaling
J0004601molecular_functionperoxidase activity
J0005737cellular_componentcytoplasm
J0005829cellular_componentcytosol
J0006111biological_processregulation of gluconeogenesis
J0006457biological_processprotein folding
J0006979biological_processresponse to oxidative stress
J0008379molecular_functionthioredoxin peroxidase activity
J0016209molecular_functionantioxidant activity
J0016491molecular_functionoxidoreductase activity
J0019207molecular_functionkinase regulator activity
J0033194biological_processresponse to hydroperoxide
J0034599biological_processcellular response to oxidative stress
J0034605biological_processcellular response to heat
J0042262biological_processDNA protection
J0042744biological_processhydrogen peroxide catabolic process
J0042802molecular_functionidentical protein binding
J0043022molecular_functionribosome binding
J0045454biological_processcell redox homeostasis
J0050821biological_processprotein stabilization
J0051082molecular_functionunfolded protein binding
J0051258biological_processprotein polymerization
J0051920molecular_functionperoxiredoxin activity
J0061077biological_processchaperone-mediated protein folding
J0071447biological_processcellular response to hydroperoxide
J0072721biological_processcellular response to dithiothreitol
J0098869biological_processcellular oxidant detoxification
J0140824molecular_functionthioredoxin-dependent peroxiredoxin activity
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE DTU B 201
ChainResidue
BPRO40
BTHR44
BPHE45
BVAL46
BSER47
BARG123

site_idAC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE DTV C 201
ChainResidue
CVAL46
CSER47
CARG123
CLEU142
CPRO40
CTHR44
CPHE45

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE DTU E 201
ChainResidue
ELEU41
ETHR44
EPHE45
EVAL46
ESER47
EARG123
ELEU142

site_idAC4
Number of Residues7
DetailsBINDING SITE FOR RESIDUE DTU G 201
ChainResidue
GTHR44
GPHE45
GVAL46
GSER47
GARG123
GLEU142
HVAL167

site_idAC5
Number of Residues8
DetailsBINDING SITE FOR RESIDUE DTU H 201
ChainResidue
GVAL167
HPRO40
HTHR44
HPHE45
HVAL46
HSER47
HARG123
HHOH322

site_idAC6
Number of Residues5
DetailsBINDING SITE FOR RESIDUE DTU J 201
ChainResidue
ATYR77
JTHR44
JPHE45
JVAL46
JARG123

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues10
DetailsACT_SITE: Cysteine sulfenic acid (-SOH) intermediate => ECO:0000305|PubMed:8041739
ChainResidueDetails
ASER47
BSER47
CSER47
DSER47
ESER47
FSER47
GSER47
HSER47
ISER47
JSER47

site_idSWS_FT_FI2
Number of Residues20
DetailsBINDING: BINDING => ECO:0000269|PubMed:22985967, ECO:0007744|PDB:3SBC
ChainResidueDetails
FTHR44
FARG123
GTHR44
GARG123
HTHR44
HARG123
ITHR44
IARG123
JTHR44
JARG123
ATHR44
AARG123
BTHR44
BARG123
CTHR44
CARG123
DTHR44
DARG123
ETHR44
EARG123

site_idSWS_FT_FI3
Number of Residues10
DetailsSITE: Important for catalytic activity, helps activating the peroxidatic cysteine through H-bonding
ChainResidueDetails
ATHR44
BTHR44
CTHR44
DTHR44
ETHR44
FTHR44
GTHR44
HTHR44
ITHR44
JTHR44

site_idSWS_FT_FI4
Number of Residues10
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198
ChainResidueDetails
ATHR173
BTHR173
CTHR173
DTHR173
ETHR173
FTHR173
GTHR173
HTHR173
ITHR173
JTHR173

site_idSWS_FT_FI5
Number of Residues40
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047
ChainResidueDetails
HLYS88
HLYS131
ILYS13
ILYS88
ILYS131
JLYS13
JLYS88
JLYS131
BLYS13
BLYS88
BLYS131
CLYS13
CLYS88
CLYS131
DLYS13
DLYS88
DLYS131
ELYS13
ELYS88
ELYS131
FLYS13
FLYS88
FLYS131
GLYS13
GLYS88
GLYS131
HLYS13
ALYS13
ALYS88
ALYS131

221051

PDB entries from 2024-06-12

PDB statisticsPDBj update infoContact PDBjnumon