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3RJ1

Architecture of the Mediator Head module

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0001097molecular_functionTFIIH-class transcription factor complex binding
A0003712molecular_functiontranscription coregulator activity
A0003713molecular_functiontranscription coactivator activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0006357biological_processregulation of transcription by RNA polymerase II
A0016592cellular_componentmediator complex
A0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0051123biological_processRNA polymerase II preinitiation complex assembly
A0060261biological_processpositive regulation of transcription initiation by RNA polymerase II
A0070847cellular_componentcore mediator complex
B0003712molecular_functiontranscription coregulator activity
B0006357biological_processregulation of transcription by RNA polymerase II
B0016592cellular_componentmediator complex
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
C0003677molecular_functionDNA binding
C0003712molecular_functiontranscription coregulator activity
C0003714molecular_functiontranscription corepressor activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0006357biological_processregulation of transcription by RNA polymerase II
C0016592cellular_componentmediator complex
C0017025molecular_functionTBP-class protein binding
C0030674molecular_functionprotein-macromolecule adaptor activity
C0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0051123biological_processRNA polymerase II preinitiation complex assembly
C0060261biological_processpositive regulation of transcription initiation by RNA polymerase II
C0070847cellular_componentcore mediator complex
D0003674molecular_functionmolecular_function
D0003712molecular_functiontranscription coregulator activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0006357biological_processregulation of transcription by RNA polymerase II
D0016592cellular_componentmediator complex
D0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0051123biological_processRNA polymerase II preinitiation complex assembly
D0060261biological_processpositive regulation of transcription initiation by RNA polymerase II
D0070847cellular_componentcore mediator complex
E0000979molecular_functionRNA polymerase II core promoter sequence-specific DNA binding
E0001113biological_processtranscription open complex formation at RNA polymerase II promoter
E0003712molecular_functiontranscription coregulator activity
E0003713molecular_functiontranscription coactivator activity
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0006357biological_processregulation of transcription by RNA polymerase II
E0006369biological_processtermination of RNA polymerase II transcription
E0016592cellular_componentmediator complex
E0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
E0034605biological_processcellular response to heat
E0045944biological_processpositive regulation of transcription by RNA polymerase II
E0051123biological_processRNA polymerase II preinitiation complex assembly
E0060261biological_processpositive regulation of transcription initiation by RNA polymerase II
E0070847cellular_componentcore mediator complex
F0001094molecular_functionTFIID-class transcription factor complex binding
F0003712molecular_functiontranscription coregulator activity
F0003713molecular_functiontranscription coactivator activity
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0006357biological_processregulation of transcription by RNA polymerase II
F0010688biological_processnegative regulation of ribosomal protein gene transcription by RNA polymerase II
F0016592cellular_componentmediator complex
F0019904molecular_functionprotein domain specific binding
F0031669biological_processcellular response to nutrient levels
F0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
F0032991cellular_componentprotein-containing complex
F0045944biological_processpositive regulation of transcription by RNA polymerase II
F0051123biological_processRNA polymerase II preinitiation complex assembly
F0060261biological_processpositive regulation of transcription initiation by RNA polymerase II
F0070847cellular_componentcore mediator complex
G0003712molecular_functiontranscription coregulator activity
G0003713molecular_functiontranscription coactivator activity
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0006357biological_processregulation of transcription by RNA polymerase II
G0016592cellular_componentmediator complex
G0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
G0045944biological_processpositive regulation of transcription by RNA polymerase II
G0051123biological_processRNA polymerase II preinitiation complex assembly
G0060261biological_processpositive regulation of transcription initiation by RNA polymerase II
G0070847cellular_componentcore mediator complex
H0000122biological_processnegative regulation of transcription by RNA polymerase II
H0001097molecular_functionTFIIH-class transcription factor complex binding
H0003712molecular_functiontranscription coregulator activity
H0003713molecular_functiontranscription coactivator activity
H0005515molecular_functionprotein binding
H0005634cellular_componentnucleus
H0006357biological_processregulation of transcription by RNA polymerase II
H0016592cellular_componentmediator complex
H0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
H0045944biological_processpositive regulation of transcription by RNA polymerase II
H0051123biological_processRNA polymerase II preinitiation complex assembly
H0060261biological_processpositive regulation of transcription initiation by RNA polymerase II
H0070847cellular_componentcore mediator complex
I0003712molecular_functiontranscription coregulator activity
I0006357biological_processregulation of transcription by RNA polymerase II
I0016592cellular_componentmediator complex
J0000122biological_processnegative regulation of transcription by RNA polymerase II
J0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
J0003677molecular_functionDNA binding
J0003712molecular_functiontranscription coregulator activity
J0003714molecular_functiontranscription corepressor activity
J0005515molecular_functionprotein binding
J0005634cellular_componentnucleus
J0006357biological_processregulation of transcription by RNA polymerase II
J0016592cellular_componentmediator complex
J0017025molecular_functionTBP-class protein binding
J0030674molecular_functionprotein-macromolecule adaptor activity
J0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
J0045944biological_processpositive regulation of transcription by RNA polymerase II
J0051123biological_processRNA polymerase II preinitiation complex assembly
J0060261biological_processpositive regulation of transcription initiation by RNA polymerase II
J0070847cellular_componentcore mediator complex
K0003674molecular_functionmolecular_function
K0003712molecular_functiontranscription coregulator activity
K0005515molecular_functionprotein binding
K0005634cellular_componentnucleus
K0006357biological_processregulation of transcription by RNA polymerase II
K0016592cellular_componentmediator complex
K0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
K0045944biological_processpositive regulation of transcription by RNA polymerase II
K0051123biological_processRNA polymerase II preinitiation complex assembly
K0060261biological_processpositive regulation of transcription initiation by RNA polymerase II
K0070847cellular_componentcore mediator complex
L0000979molecular_functionRNA polymerase II core promoter sequence-specific DNA binding
L0001113biological_processtranscription open complex formation at RNA polymerase II promoter
L0003712molecular_functiontranscription coregulator activity
L0003713molecular_functiontranscription coactivator activity
L0005515molecular_functionprotein binding
L0005634cellular_componentnucleus
L0006357biological_processregulation of transcription by RNA polymerase II
L0006369biological_processtermination of RNA polymerase II transcription
L0016592cellular_componentmediator complex
L0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
L0034605biological_processcellular response to heat
L0045944biological_processpositive regulation of transcription by RNA polymerase II
L0051123biological_processRNA polymerase II preinitiation complex assembly
L0060261biological_processpositive regulation of transcription initiation by RNA polymerase II
L0070847cellular_componentcore mediator complex
M0001094molecular_functionTFIID-class transcription factor complex binding
M0003712molecular_functiontranscription coregulator activity
M0003713molecular_functiontranscription coactivator activity
M0005515molecular_functionprotein binding
M0005634cellular_componentnucleus
M0006357biological_processregulation of transcription by RNA polymerase II
M0010688biological_processnegative regulation of ribosomal protein gene transcription by RNA polymerase II
M0016592cellular_componentmediator complex
M0019904molecular_functionprotein domain specific binding
M0031669biological_processcellular response to nutrient levels
M0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
M0032991cellular_componentprotein-containing complex
M0045944biological_processpositive regulation of transcription by RNA polymerase II
M0051123biological_processRNA polymerase II preinitiation complex assembly
M0060261biological_processpositive regulation of transcription initiation by RNA polymerase II
M0070847cellular_componentcore mediator complex
N0003712molecular_functiontranscription coregulator activity
N0003713molecular_functiontranscription coactivator activity
N0005515molecular_functionprotein binding
N0005634cellular_componentnucleus
N0006357biological_processregulation of transcription by RNA polymerase II
N0016592cellular_componentmediator complex
N0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
N0045944biological_processpositive regulation of transcription by RNA polymerase II
N0051123biological_processRNA polymerase II preinitiation complex assembly
N0060261biological_processpositive regulation of transcription initiation by RNA polymerase II
N0070847cellular_componentcore mediator complex
O0000122biological_processnegative regulation of transcription by RNA polymerase II
O0001097molecular_functionTFIIH-class transcription factor complex binding
O0003712molecular_functiontranscription coregulator activity
O0003713molecular_functiontranscription coactivator activity
O0005515molecular_functionprotein binding
O0005634cellular_componentnucleus
O0006357biological_processregulation of transcription by RNA polymerase II
O0016592cellular_componentmediator complex
O0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
O0045944biological_processpositive regulation of transcription by RNA polymerase II
O0051123biological_processRNA polymerase II preinitiation complex assembly
O0060261biological_processpositive regulation of transcription initiation by RNA polymerase II
O0070847cellular_componentcore mediator complex
P0003712molecular_functiontranscription coregulator activity
P0006357biological_processregulation of transcription by RNA polymerase II
P0016592cellular_componentmediator complex
Q0000122biological_processnegative regulation of transcription by RNA polymerase II
Q0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Q0003677molecular_functionDNA binding
Q0003712molecular_functiontranscription coregulator activity
Q0003714molecular_functiontranscription corepressor activity
Q0005515molecular_functionprotein binding
Q0005634cellular_componentnucleus
Q0006357biological_processregulation of transcription by RNA polymerase II
Q0016592cellular_componentmediator complex
Q0017025molecular_functionTBP-class protein binding
Q0030674molecular_functionprotein-macromolecule adaptor activity
Q0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
Q0045944biological_processpositive regulation of transcription by RNA polymerase II
Q0051123biological_processRNA polymerase II preinitiation complex assembly
Q0060261biological_processpositive regulation of transcription initiation by RNA polymerase II
Q0070847cellular_componentcore mediator complex
R0003674molecular_functionmolecular_function
R0003712molecular_functiontranscription coregulator activity
R0005515molecular_functionprotein binding
R0005634cellular_componentnucleus
R0006357biological_processregulation of transcription by RNA polymerase II
R0016592cellular_componentmediator complex
R0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
R0045944biological_processpositive regulation of transcription by RNA polymerase II
R0051123biological_processRNA polymerase II preinitiation complex assembly
R0060261biological_processpositive regulation of transcription initiation by RNA polymerase II
R0070847cellular_componentcore mediator complex
S0000979molecular_functionRNA polymerase II core promoter sequence-specific DNA binding
S0001113biological_processtranscription open complex formation at RNA polymerase II promoter
S0003712molecular_functiontranscription coregulator activity
S0003713molecular_functiontranscription coactivator activity
S0005515molecular_functionprotein binding
S0005634cellular_componentnucleus
S0006357biological_processregulation of transcription by RNA polymerase II
S0006369biological_processtermination of RNA polymerase II transcription
S0016592cellular_componentmediator complex
S0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
S0034605biological_processcellular response to heat
S0045944biological_processpositive regulation of transcription by RNA polymerase II
S0051123biological_processRNA polymerase II preinitiation complex assembly
S0060261biological_processpositive regulation of transcription initiation by RNA polymerase II
S0070847cellular_componentcore mediator complex
T0001094molecular_functionTFIID-class transcription factor complex binding
T0003712molecular_functiontranscription coregulator activity
T0003713molecular_functiontranscription coactivator activity
T0005515molecular_functionprotein binding
T0005634cellular_componentnucleus
T0006357biological_processregulation of transcription by RNA polymerase II
T0010688biological_processnegative regulation of ribosomal protein gene transcription by RNA polymerase II
T0016592cellular_componentmediator complex
T0019904molecular_functionprotein domain specific binding
T0031669biological_processcellular response to nutrient levels
T0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
T0032991cellular_componentprotein-containing complex
T0045944biological_processpositive regulation of transcription by RNA polymerase II
T0051123biological_processRNA polymerase II preinitiation complex assembly
T0060261biological_processpositive regulation of transcription initiation by RNA polymerase II
T0070847cellular_componentcore mediator complex
U0003712molecular_functiontranscription coregulator activity
U0003713molecular_functiontranscription coactivator activity
U0005515molecular_functionprotein binding
U0005634cellular_componentnucleus
U0006357biological_processregulation of transcription by RNA polymerase II
U0016592cellular_componentmediator complex
U0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
U0045944biological_processpositive regulation of transcription by RNA polymerase II
U0051123biological_processRNA polymerase II preinitiation complex assembly
U0060261biological_processpositive regulation of transcription initiation by RNA polymerase II
U0070847cellular_componentcore mediator complex
Functional Information from PDB Data
site_idAC1
Number of Residues1
DetailsBINDING SITE FOR RESIDUE SE A 133
ChainResidue
AMSE114

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SE B 1728
ChainResidue
BMSE207
GTHR184
GLEU188

site_idAC3
Number of Residues1
DetailsBINDING SITE FOR RESIDUE SE B 1729
ChainResidue
BLEU229

site_idAC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SE B 1730
ChainResidue
BMSE238
BSER239
BSER242

site_idAC5
Number of Residues1
DetailsBINDING SITE FOR RESIDUE SE B 1732
ChainResidue
BLEU510

site_idAC6
Number of Residues1
DetailsBINDING SITE FOR RESIDUE SE B 903
ChainResidue
BGLU440

site_idAC7
Number of Residues1
DetailsBINDING SITE FOR RESIDUE SE B 904
ChainResidue
BSER480

site_idAC8
Number of Residues1
DetailsBINDING SITE FOR RESIDUE SE C 224
ChainResidue
CARG51

site_idAC9
Number of Residues1
DetailsBINDING SITE FOR RESIDUE SE C 225
ChainResidue
CMSE38

site_idBC1
Number of Residues1
DetailsBINDING SITE FOR RESIDUE SE C 226
ChainResidue
CMSE54

site_idBC2
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SE D 222
ChainResidue
DTHR28
DMSE57

site_idBC3
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SE D 223
ChainResidue
DMSE56
DASN60

site_idBC4
Number of Residues1
DetailsBINDING SITE FOR RESIDUE SE E 409
ChainResidue
EMSE182

site_idBC5
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SE E 410
ChainResidue
ETRP41
EMSE204
ETYR209

site_idBC6
Number of Residues1
DetailsBINDING SITE FOR RESIDUE SE E 411
ChainResidue
ESER27

site_idBC7
Number of Residues1
DetailsBINDING SITE FOR RESIDUE SE G 1299
ChainResidue
GMSE101

site_idBC8
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SE D 1301
ChainResidue
DLEU48
GMSE175

site_idBC9
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SE H 313
ChainResidue
HGLU85
HLEU89

site_idCC1
Number of Residues1
DetailsBINDING SITE FOR RESIDUE SE I 1728
ChainResidue
IMSE238

site_idCC2
Number of Residues1
DetailsBINDING SITE FOR RESIDUE SE I 1729
ChainResidue
ISER226

site_idCC3
Number of Residues1
DetailsBINDING SITE FOR RESIDUE SE I 903
ChainResidue
ISER480

site_idCC4
Number of Residues1
DetailsBINDING SITE FOR RESIDUE SE I 904
ChainResidue
IPHE200

site_idCC5
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SE I 906
ChainResidue
ILEU479
ISER480

site_idCC6
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SE J 225
ChainResidue
JGLU53
JMSE54

site_idCC7
Number of Residues1
DetailsBINDING SITE FOR RESIDUE SE K 173
ChainResidue
KSER54

site_idCC8
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SE K 174
ChainResidue
KTHR62
KMSE63

site_idCC9
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SE K 175
ChainResidue
KLEU48
NMSE175

site_idDC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SE K 177
ChainResidue
KTHR28
KTHR29
KMSE57

site_idDC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SE L 408
ChainResidue
LSER73
LILE76
LASP77
LGLU78
LMSE80
LMSE81

site_idDC3
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SE L 409
ChainResidue
LILE76
LMSE81

site_idDC4
Number of Residues1
DetailsBINDING SITE FOR RESIDUE SE L 410
ChainResidue
LMSE182

site_idDC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SE L 412
ChainResidue
LSER27
LPHE222
LPHE223
LMSE224

site_idDC6
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SE L 413
ChainResidue
LMSE276
LLYS279

site_idDC7
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SE L 414
ChainResidue
LPRO291
LASP292
LMSE296

site_idDC8
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SE L 415
ChainResidue
LMSE204
LTYR209

site_idDC9
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SE N 396
ChainResidue
IMSE207
IILE211
NTHR184

site_idEC1
Number of Residues1
DetailsBINDING SITE FOR RESIDUE SE N 397
ChainResidue
NPHE52

site_idEC2
Number of Residues1
DetailsBINDING SITE FOR RESIDUE SE N 398
ChainResidue
NMSE99

site_idEC3
Number of Residues1
DetailsBINDING SITE FOR RESIDUE SE N 400
ChainResidue
NLEU107

site_idEC4
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SE O 132
ChainResidue
OMSE39
OLEU40

site_idEC5
Number of Residues1
DetailsBINDING SITE FOR RESIDUE SE O 133
ChainResidue
OMSE114

site_idEC6
Number of Residues1
DetailsBINDING SITE FOR RESIDUE SE O 313
ChainResidue
OASN92

site_idEC7
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SE P 1728
ChainResidue
PMSE207
PLEU208
PILE211

site_idEC8
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SE P 1730
ChainResidue
PMSE238
PSE1731

site_idEC9
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SE P 1731
ChainResidue
PSER226
PLEU229
PSE1730

site_idFC1
Number of Residues1
DetailsBINDING SITE FOR RESIDUE SE P 1733
ChainResidue
PMSE507

site_idFC2
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SE P 902
ChainResidue
PSER480
PLEU481

site_idFC3
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SE Q 325
ChainResidue
QGLU53
QMSE54

site_idFC4
Number of Residues1
DetailsBINDING SITE FOR RESIDUE SE Q 326
ChainResidue
QMSE126

site_idFC5
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SE Q 327
ChainResidue
QSER78
RMSE56

site_idFC6
Number of Residues1
DetailsBINDING SITE FOR RESIDUE SE R 222
ChainResidue
RTHR53

site_idFC7
Number of Residues1
DetailsBINDING SITE FOR RESIDUE SE R 223
ChainResidue
RSER54

site_idFC8
Number of Residues1
DetailsBINDING SITE FOR RESIDUE SE S 308
ChainResidue
SSER92

site_idFC9
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SE S 309
ChainResidue
SLEU5
SMSE182

site_idGC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SE S 310
ChainResidue
STRP41
SILE64
SMSE204
STYR209

site_idGC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SE T 311
ChainResidue
TMSE57
TTYR58
TLEU71

site_idGC3
Number of Residues1
DetailsBINDING SITE FOR RESIDUE SE U 496
ChainResidue
UTYR189

site_idGC4
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SE U 499
ChainResidue
UGLU104
UGLU105

site_idGC5
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SE U 500
ChainResidue
USER172
UMSE175

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19779198
ChainResidueDetails
GSER225
NSER225
USER225

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PDB entries from 2024-07-17

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