3RDE
Crystal structure of the catalytic domain of porcine leukocyte 12-lipoxygenase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0016702 | molecular_function | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
| A | 0034440 | biological_process | lipid oxidation |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0005506 | molecular_function | iron ion binding |
| B | 0016702 | molecular_function | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
| B | 0034440 | biological_process | lipid oxidation |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0005506 | molecular_function | iron ion binding |
| C | 0016702 | molecular_function | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
| C | 0034440 | biological_process | lipid oxidation |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0005506 | molecular_function | iron ion binding |
| D | 0016702 | molecular_function | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
| D | 0034440 | biological_process | lipid oxidation |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE K A 2 |
| Chain | Residue |
| A | THR116 |
| A | ASP119 |
| A | HIS483 |
| A | HOH825 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FE2 A 1 |
| Chain | Residue |
| A | ILE663 |
| A | HOH5 |
| A | HIS361 |
| A | HIS366 |
| A | HIS541 |
| A | HIS545 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE OYP A 664 |
| Chain | Residue |
| A | HOH5 |
| A | PHE175 |
| A | LEU179 |
| A | GLU357 |
| A | HIS361 |
| A | HIS366 |
| A | ARG403 |
| A | ALA404 |
| A | LEU408 |
| A | VAL418 |
| A | GLN590 |
| A | ILE593 |
| A | GLN596 |
| A | HOH899 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FE2 B 2 |
| Chain | Residue |
| B | HOH6 |
| B | HIS361 |
| B | HIS366 |
| B | HIS541 |
| B | HIS545 |
| B | ILE663 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE OYP B 664 |
| Chain | Residue |
| B | PHE175 |
| B | LEU179 |
| B | GLU357 |
| B | HIS361 |
| B | HIS366 |
| B | ILE400 |
| B | ARG403 |
| B | ALA404 |
| B | VAL418 |
| B | ILE593 |
| B | GLN596 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FE2 C 3 |
| Chain | Residue |
| C | HOH7 |
| C | HIS361 |
| C | HIS366 |
| C | HIS541 |
| C | HIS545 |
| C | ILE663 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE OYP C 664 |
| Chain | Residue |
| C | PHE175 |
| C | LEU179 |
| C | GLU357 |
| C | HIS366 |
| C | ARG403 |
| C | ALA404 |
| C | GLY407 |
| C | LEU408 |
| C | VAL418 |
| C | GLN596 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE K D 1 |
| Chain | Residue |
| D | LEU282 |
| D | ILE285 |
| D | HOH688 |
| D | HOH1024 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FE2 D 4 |
| Chain | Residue |
| D | HOH8 |
| D | HIS361 |
| D | HIS366 |
| D | HIS541 |
| D | HIS545 |
| D | ILE663 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE OYP D 664 |
| Chain | Residue |
| D | LEU179 |
| D | GLU357 |
| D | HIS361 |
| D | HIS366 |
| D | ALA404 |
| D | VAL418 |
| D | LEU597 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2188 |
| Details | Domain: {"description":"Lipoxygenase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00726","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00726","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
