3QU6
Crystal structure of IRF-3 DBD free form
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000976 | molecular_function | transcription cis-regulatory region binding |
A | 0003700 | molecular_function | DNA-binding transcription factor activity |
A | 0006355 | biological_process | regulation of DNA-templated transcription |
B | 0000976 | molecular_function | transcription cis-regulatory region binding |
B | 0003700 | molecular_function | DNA-binding transcription factor activity |
B | 0006355 | biological_process | regulation of DNA-templated transcription |
C | 0000976 | molecular_function | transcription cis-regulatory region binding |
C | 0003700 | molecular_function | DNA-binding transcription factor activity |
C | 0006355 | biological_process | regulation of DNA-templated transcription |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ZN A 114 |
Chain | Residue |
A | GLU59 |
A | CL123 |
C | VAL13 |
C | ASP17 |
C | HOH155 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ZN A 115 |
Chain | Residue |
B | GLU59 |
A | VAL13 |
A | ASP17 |
A | CL119 |
A | HOH164 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 116 |
Chain | Residue |
A | ASP99 |
A | HIS101 |
A | CL120 |
B | GLU94 |
site_id | AC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 117 |
Chain | Residue |
A | GLU94 |
A | HIS104 |
B | ASP102 |
B | CL116 |
site_id | AC5 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE CL A 118 |
Chain | Residue |
A | ARG96 |
A | ASP102 |
A | HIS104 |
B | GLU94 |
B | ARG96 |
B | HIS104 |
B | ZN114 |
site_id | AC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CL A 119 |
Chain | Residue |
A | ASP17 |
A | ZN115 |
A | HOH166 |
B | PHE51 |
B | GLN55 |
B | GLU59 |
site_id | AC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CL A 120 |
Chain | Residue |
A | ASP99 |
A | HIS101 |
A | ZN116 |
B | GLU94 |
site_id | AC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE NA A 121 |
Chain | Residue |
A | GLY23 |
A | HOH137 |
B | GLY23 |
B | HOH131 |
site_id | AC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE NA A 122 |
Chain | Residue |
A | ASP50 |
A | GLY52 |
A | GLN55 |
site_id | BC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN B 114 |
Chain | Residue |
A | ASP102 |
A | CL118 |
B | GLU94 |
B | HIS104 |
site_id | BC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CL A 123 |
Chain | Residue |
A | PHE51 |
A | GLN55 |
A | GLU59 |
A | ZN114 |
A | HOH134 |
C | ASP17 |
site_id | BC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN B 115 |
Chain | Residue |
A | GLU94 |
B | GLU88 |
B | ASP99 |
B | HIS101 |
site_id | BC4 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE CL B 116 |
Chain | Residue |
A | GLU94 |
A | HIS104 |
A | ZN117 |
B | ARG96 |
B | ASP99 |
B | ASP102 |
B | HIS104 |
site_id | BC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE NA B 117 |
Chain | Residue |
B | GLY52 |
B | PHE54 |
B | GLN55 |
site_id | BC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN C 114 |
Chain | Residue |
B | ASP17 |
C | GLU59 |
C | CL118 |
C | HOH165 |
site_id | BC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ZN C 115 |
Chain | Residue |
C | GLU94 |
C | ASP102 |
C | HIS104 |
C | ILE106 |
C | CL119 |
site_id | BC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN C 116 |
Chain | Residue |
C | GLU94 |
C | ASP99 |
C | HIS101 |
C | HOH142 |
site_id | BC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CL C 118 |
Chain | Residue |
B | ASP17 |
C | GLU59 |
C | ZN114 |
C | HOH159 |
site_id | CC1 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE CL C 119 |
Chain | Residue |
C | GLU94 |
C | ARG96 |
C | ASP99 |
C | ASP102 |
C | HIS104 |
C | HIS104 |
C | ZN115 |
Functional Information from PROSITE/UniProt
site_id | PS00601 |
Number of Residues | 33 |
Details | IRF_1 IRF tryptophan pentad repeat DNA-binding domain signature. WvNksrtrFrIPWkHglrqdaqqe.DfgIFQaWA |
Chain | Residue | Details |
A | TRP26-ALA58 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 318 |
Details | DNA_BIND: IRF tryptophan pentad repeat => ECO:0000255|PROSITE-ProRule:PRU00840 |
Chain | Residue | Details |
A | LYS5-ASN111 | |
B | LYS5-ASN111 | |
C | LYS5-ASN111 |
site_id | SWS_FT_FI2 |
Number of Residues | 6 |
Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:23746807 |
Chain | Residue | Details |
A | THR3 | |
A | THR75 | |
B | THR3 | |
B | THR75 | |
C | THR3 | |
C | THR75 |
site_id | SWS_FT_FI3 |
Number of Residues | 6 |
Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:23746807 |
Chain | Residue | Details |
A | SER14 | |
A | SER97 | |
B | SER14 | |
B | SER97 | |
C | SER14 | |
C | SER97 |