3QU6
Crystal structure of IRF-3 DBD free form
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000976 | molecular_function | transcription cis-regulatory region binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0000976 | molecular_function | transcription cis-regulatory region binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0000976 | molecular_function | transcription cis-regulatory region binding |
| C | 0003700 | molecular_function | DNA-binding transcription factor activity |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 114 |
| Chain | Residue |
| A | GLU59 |
| A | CL123 |
| C | VAL13 |
| C | ASP17 |
| C | HOH155 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 115 |
| Chain | Residue |
| B | GLU59 |
| A | VAL13 |
| A | ASP17 |
| A | CL119 |
| A | HOH164 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 116 |
| Chain | Residue |
| A | ASP99 |
| A | HIS101 |
| A | CL120 |
| B | GLU94 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 117 |
| Chain | Residue |
| A | GLU94 |
| A | HIS104 |
| B | ASP102 |
| B | CL116 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CL A 118 |
| Chain | Residue |
| A | ARG96 |
| A | ASP102 |
| A | HIS104 |
| B | GLU94 |
| B | ARG96 |
| B | HIS104 |
| B | ZN114 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL A 119 |
| Chain | Residue |
| A | ASP17 |
| A | ZN115 |
| A | HOH166 |
| B | PHE51 |
| B | GLN55 |
| B | GLU59 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 120 |
| Chain | Residue |
| A | ASP99 |
| A | HIS101 |
| A | ZN116 |
| B | GLU94 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA A 121 |
| Chain | Residue |
| A | GLY23 |
| A | HOH137 |
| B | GLY23 |
| B | HOH131 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NA A 122 |
| Chain | Residue |
| A | ASP50 |
| A | GLY52 |
| A | GLN55 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 114 |
| Chain | Residue |
| A | ASP102 |
| A | CL118 |
| B | GLU94 |
| B | HIS104 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL A 123 |
| Chain | Residue |
| A | PHE51 |
| A | GLN55 |
| A | GLU59 |
| A | ZN114 |
| A | HOH134 |
| C | ASP17 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 115 |
| Chain | Residue |
| A | GLU94 |
| B | GLU88 |
| B | ASP99 |
| B | HIS101 |
| site_id | BC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CL B 116 |
| Chain | Residue |
| A | GLU94 |
| A | HIS104 |
| A | ZN117 |
| B | ARG96 |
| B | ASP99 |
| B | ASP102 |
| B | HIS104 |
| site_id | BC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NA B 117 |
| Chain | Residue |
| B | GLY52 |
| B | PHE54 |
| B | GLN55 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 114 |
| Chain | Residue |
| B | ASP17 |
| C | GLU59 |
| C | CL118 |
| C | HOH165 |
| site_id | BC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN C 115 |
| Chain | Residue |
| C | GLU94 |
| C | ASP102 |
| C | HIS104 |
| C | ILE106 |
| C | CL119 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 116 |
| Chain | Residue |
| C | GLU94 |
| C | ASP99 |
| C | HIS101 |
| C | HOH142 |
| site_id | BC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL C 118 |
| Chain | Residue |
| B | ASP17 |
| C | GLU59 |
| C | ZN114 |
| C | HOH159 |
| site_id | CC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CL C 119 |
| Chain | Residue |
| C | GLU94 |
| C | ARG96 |
| C | ASP99 |
| C | ASP102 |
| C | HIS104 |
| C | HIS104 |
| C | ZN115 |
Functional Information from PROSITE/UniProt
| site_id | PS00601 |
| Number of Residues | 33 |
| Details | IRF_1 IRF tryptophan pentad repeat DNA-binding domain signature. WvNksrtrFrIPWkHglrqdaqqe.DfgIFQaWA |
| Chain | Residue | Details |
| A | TRP26-ALA58 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 48 |
| Details | Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23746807","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23746807","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
