3QG5
The Mre11:Rad50 complex forms an ATP dependent molecular clamp in DNA double-strand break repair
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006302 | biological_process | double-strand break repair |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| B | 0006302 | biological_process | double-strand break repair |
| B | 0016887 | molecular_function | ATP hydrolysis activity |
| C | 0003677 | molecular_function | DNA binding |
| C | 0004519 | molecular_function | endonuclease activity |
| C | 0004520 | molecular_function | DNA endonuclease activity |
| C | 0004527 | molecular_function | exonuclease activity |
| C | 0004529 | molecular_function | DNA exonuclease activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0006259 | biological_process | DNA metabolic process |
| C | 0006260 | biological_process | DNA replication |
| C | 0006281 | biological_process | DNA repair |
| C | 0006302 | biological_process | double-strand break repair |
| C | 0006310 | biological_process | DNA recombination |
| C | 0008408 | molecular_function | 3'-5' exonuclease activity |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0003677 | molecular_function | DNA binding |
| D | 0004519 | molecular_function | endonuclease activity |
| D | 0004520 | molecular_function | DNA endonuclease activity |
| D | 0004527 | molecular_function | exonuclease activity |
| D | 0004529 | molecular_function | DNA exonuclease activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0006259 | biological_process | DNA metabolic process |
| D | 0006260 | biological_process | DNA replication |
| D | 0006281 | biological_process | DNA repair |
| D | 0006302 | biological_process | double-strand break repair |
| D | 0006310 | biological_process | DNA recombination |
| D | 0008408 | molecular_function | 3'-5' exonuclease activity |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL D 3968 |
| Chain | Residue |
| C | LEU75 |
| C | PHE102 |
| D | LYS97 |
| D | PHE102 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL A 3968 |
| Chain | Residue |
| A | ARG136 |
| A | GLU144 |
Functional Information from PROSITE/UniProt
| site_id | PS00211 |
| Number of Residues | 15 |
| Details | ABC_TRANSPORTER_1 ABC transporters family signature. LSGGERALISISLAM |
| Chain | Residue | Details |
| A | LEU767-MSE781 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor => ECO:0000250|UniProtKB:Q8U1N9, ECO:0000255|HAMAP-Rule:MF_02044 |
| Chain | Residue | Details |
| C | HIS94 | |
| D | HIS94 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21937514, ECO:0000269|PubMed:24316220, ECO:0007744|PDB:3THN, ECO:0007744|PDB:3THO, ECO:0007744|PDB:4NZV, ECO:0007744|PDB:4O24, ECO:0007744|PDB:4O43, ECO:0007744|PDB:4O4K, ECO:0007744|PDB:4O5G |
| Chain | Residue | Details |
| C | ASP14 | |
| C | HIS16 | |
| C | ASP58 | |
| C | HIS216 | |
| D | ASP14 | |
| D | HIS16 | |
| D | ASP58 | |
| D | HIS216 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21937514, ECO:0000269|PubMed:24316220, ECO:0007744|PDB:3THN, ECO:0007744|PDB:3THO, ECO:0007744|PDB:4NZV, ECO:0007744|PDB:4O24, ECO:0007744|PDB:4O4K |
| Chain | Residue | Details |
| C | HIS180 | |
| B | ARG63 | |
| D | HIS180 | |
| A | SER38 | |
| A | ARG53 | |
| A | ARG63 | |
| B | GLY35 | |
| B | LYS36 | |
| B | SER38 | |
| B | ARG53 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21937514, ECO:0000269|PubMed:24316220, ECO:0007744|PDB:4NZV |
| Chain | Residue | Details |
| C | HIS218 | |
| D | HIS218 | |
| B | SER37 | |
| B | GLN142 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:21458667, ECO:0000305|PubMed:25349191, ECO:0007744|PDB:3QF7, ECO:0007744|PDB:3THO, ECO:0007744|PDB:4W9M |
| Chain | Residue | Details |
| A | ASP59 | |
| B | ASP59 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:21458667, ECO:0000305|PubMed:21937514, ECO:0007744|PDB:3QF7, ECO:0007744|PDB:3THO |
| Chain | Residue | Details |
| A | VAL61 | |
| B | VAL61 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0007744|PDB:4W9M |
| Chain | Residue | Details |
| A | ASP797 | |
| B | ASP797 |
