3QG5

The Mre11:Rad50 complex forms an ATP dependent molecular clamp in DNA double-strand break repair

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006302	biological_process	double-strand break repair
A	0016887	molecular_function	ATP hydrolysis activity
B	0006302	biological_process	double-strand break repair
B	0016887	molecular_function	ATP hydrolysis activity
C	0003677	molecular_function	DNA binding
C	0004518	molecular_function	nuclease activity
C	0004519	molecular_function	endonuclease activity
C	0004520	molecular_function	DNA endonuclease activity
C	0004527	molecular_function	exonuclease activity
C	0004529	molecular_function	DNA exonuclease activity
C	0005515	molecular_function	protein binding
C	0006259	biological_process	DNA metabolic process
C	0006260	biological_process	DNA replication
C	0006281	biological_process	DNA repair
C	0006302	biological_process	double-strand break repair
C	0006310	biological_process	DNA recombination
C	0008408	molecular_function	3'-5' exonuclease activity
C	0016787	molecular_function	hydrolase activity
C	0046872	molecular_function	metal ion binding
D	0003677	molecular_function	DNA binding
D	0004518	molecular_function	nuclease activity
D	0004519	molecular_function	endonuclease activity
D	0004520	molecular_function	DNA endonuclease activity
D	0004527	molecular_function	exonuclease activity
D	0004529	molecular_function	DNA exonuclease activity
D	0005515	molecular_function	protein binding
D	0006259	biological_process	DNA metabolic process
D	0006260	biological_process	DNA replication
D	0006281	biological_process	DNA repair
D	0006302	biological_process	double-strand break repair
D	0006310	biological_process	DNA recombination
D	0008408	molecular_function	3'-5' exonuclease activity
D	0016787	molecular_function	hydrolase activity
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL D 3968

Chain	Residue
C	LEU75
C	PHE102
D	LYS97
D	PHE102

---

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL A 3968

Chain	Residue
A	ARG136
A	GLU144

---

Functional Information from PROSITE/UniProt

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. LSGGERALISISLAM

Chain	Residue	Details
A	LEU767-MSE781

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21458667","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3QF7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21937514","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3THO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21458667","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21937514","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25349191","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3QF7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3THO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4W9M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21458667","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25349191","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3QF7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4W9M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21458667","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25349191","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3QF7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3THO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4W9M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21458667","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21937514","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3QF7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3THO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PDB","id":"4W9M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"Q8U1N9","evidenceCode":"ECO:0000250"},{"source":"HAMAP-Rule","id":"MF_02044","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21937514","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24316220","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3THN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3THO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NZV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4O24","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4O43","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4O4K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4O5G","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21937514","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24316220","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3THN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3THO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NZV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4O24","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4O4K","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21937514","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24316220","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4NZV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---